Perform: Assessment of Body Composition and Physical Function
Study Details
Study Description
Brief Summary
Sarcopenia, which is the loss of muscle mass and strength or physical function, naturally occurs in aging. In sarcopenic obesity, growth of muscle mass and increments in strength do not parallel weight gain, and places older adults at increased risk of falls, fractures, physical disability, frailty, and mortality from too low muscle strength relative to body size. The goal of the study is to assess body composition and physical function in older adults with obesity.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
This is a cross-sectional study in 40 adults aged 60 to 80 years with obesity. Body composition, physical function, and insulin resistance will be measured. Subjects who satisfy the eligibility criteria and sign the informed consent will be enrolled. Subjects will complete an assessment of body composition by bioelectrical impedance analysis and tests of physical performance. Blood will be drawn for measurement of fasting glucose and insulin.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Older Adults Adults 60-80 years of age with body mass index > 30kg/m2 |
Other: Body Composition Assessment
Assessment of body composition using bioelectrical impedance analysis.
Other: Modified Physical Performance Test
A test of physical functioning
Other: Hand grip strength
A test of hand grip strength using a hand dynamometer.
Other: 6-minute walk test
Self-paced test of walking capacity.
Procedure: Measurement of blood glucose and insulin
Blood will be drawn for measurement of glucose and insulin.
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Outcome Measures
Primary Outcome Measures
- Fat mass [One day]
Measurement of fat mass
- Fat-free mass [One day]
Measurement of fat-free mass
- Modified Physical Performance Test [One day]
Assessment of physical function
Secondary Outcome Measures
- Hand grip strength [One day]
Assessment of grip strength using a hand dynamometer
- 6-minute walk test [One day]
Test of walking capacity assessed as distance covered in 6 minutes
- Insulin resistance [One day]
Assessment of insulin resistance from blood glucose and insulin
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Body mass index > 30kg/m2
-
Age 60 - 80 years
Exclusion Criteria:
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self-reported history of diabetes, or cancer or significant cardiovascular or hepatic or renal disease or dysfunction.
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clinically significant gastrointestinal malabsorption syndromes such as chronic diarrhea, or celiac disease.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Pennington Biomedical Research Center | Baton Rouge | Louisiana | United States | 70808 |
Sponsors and Collaborators
- Pennington Biomedical Research Center
Investigators
- Principal Investigator: Candida J Rebello, Ph.D., Pennington Biomedical Research Center
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PBRC 2023-001