Assessment of Executive Functions After Covid-19
Study Details
Study Description
Brief Summary
As it is evident that Covid-19 may have some impacts on cognition, the primary aim of this study is to investigate -if any- deficits of attention, working memory and executive functions after Covid-19.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Since Covid-19 (Coronavirus Disease-2019) was declared as a pandemic by the World Health Organization (WHO) on December 31, 2019, it is still widespread and deadly. As an ongoing pandemic, it has led to a panic and then a controlled fear in societies. In many studies, neuropsychological deficits were observed in Covid-19 patients both during the illness and after recovery. A recent study found that impairment in cognitive functions continued after recovery of Covid-19, and it was associated with peripherical inflammatory markers, such as C-Reactive Protein (CRP). CRP, as a peripherical inflammatory marker, has been proven to be inversely related to serum levels of the brain-derived neurotrophic factor (BDNF), an important neurotrophin in the growth and differentiation of neurons. In this study, attention, working memory and executive functions of Covid-19 patients at post-covid period and its relation with the severity of the disease will be investigated.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Patients Subjects who have been Covid positive by RT-PCR at least 60 days ago and not having any symptoms of Covid-19 at the moment |
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| Healthy Subjects who do not have any general medical, neurological or psychiatric disorder |
Outcome Measures
Primary Outcome Measures
- Neuropsychological test scores [Up to 90 days]
Neuropsychological test scores of Covid-19 patients in comparison with healthy control subjects
Secondary Outcome Measures
- Severity of the disease [Up to 90 days]
Neuropsychological test score changes according to the disease severity of Covid-19 patients
Eligibility Criteria
Criteria
Inclusion Criteria:
Covid-19 patients:
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Diagnosed as Covid-19 by RT-PCR at least 60 days but not more than 90 days ago
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Asymptomatic at the moment
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Not having any other general medical, neurological or psychiatric conditions except Covid-19 at the time of acute infection
Healthy subjects:
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Not having any of Covid-19 symptoms at the testing time point
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Not having any general medical, neurological or psychiatric condition
Exclusion Criteria:
Covid-19 patients:
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Diagnosed as Covid-19 by RT-PCR less than 60 days or more than 90 days ago
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Having any symptom of acute phase of Covid-19
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Having any other general medical, neurlogical or psychiatric contidions
Healthy subjects:
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Having any of Covid-19 symptoms at the testing time point
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Having any general medical, neurological or psychiatric condition
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Sağlık Bilimleri Üniversitesi Gazi Yaşargil Training and Research Hospital | Diyarbakır | Turkey | 21070 |
Sponsors and Collaborators
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Investigators
- Principal Investigator: Mehmet D Güleken, MD, Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
- Guo Q, Zheng Y, Shi J, Wang J, Li G, Li C, Fromson JA, Xu Y, Liu X, Xu H, Zhang T, Lu Y, Chen X, Hu H, Tang Y, Yang S, Zhou H, Wang X, Chen H, Wang Z, Yang Z. Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: A mixed-method study. Brain Behav Immun. 2020 Aug;88:17-27. doi: 10.1016/j.bbi.2020.05.038. Epub 2020 May 19.
- Wilson BA, Betteridge S, Fish J. Neuropsychological consequences of Covid-19. Neuropsychol Rehabil. 2020 Oct;30(9):1625-1628. doi: 10.1080/09602011.2020.1808483.
- Zhou H, Lu S, Chen J, Wei N, Wang D, Lyu H, Shi C, Hu S. The landscape of cognitive function in recovered COVID-19 patients. J Psychiatr Res. 2020 Oct;129:98-102. doi: 10.1016/j.jpsychires.2020.06.022. Epub 2020 Jun 30.
- 21022021