ARTE-MISO: Assessment of Hypoxia Before Radioembolization Treatment With 18F-FMISO PET
Study Details
Study Description
Brief Summary
Hypoxia is a known factor for resistance to radiotherapy in tumors. Response to transarterial radioembolization is known to be variable between different patients even if the same dose of radiation was delivered. In this study the investigators aim to quantify the hypoxia in the primary and secondary tumors of liver with 18F-FMISO PET before radioembolization and to prove any effect of the hypoxia, if present, on the dose that should be delivered to tumor to ensure treatment response.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Treatment group Patients received radioembolization with hepatocellular cancer or colorectal cancer liver metastases |
Diagnostic Test: 18F-Fluoromisonidazole PET
Imaging of hypoxia before radioembolization with 18F-Fluoromisonidazole PET.
|
Outcome Measures
Primary Outcome Measures
- Demonstrate the effect of the hypoxia in the success of the radioembolization treatment [08/2024]
Demonstrate the effect of the hypoxia in the success of the radioembolization treatment
- The effect of the hypoxia on the dose-response relationships and required doses to achieve treatment response in the hypoxic and non-hypoxic group. [08/2024]
The effect of the hypoxia on the dose-response relationships and required doses to achieve treatment response in the hypoxic and non-hypoxic group.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Diagnosed with colorectal carcinoma with liver metastasis or hepatocellular carcinoma.
-
Is not eligible for surgery
-
Above 18 years old
-
The patients who are referred for transarterial radioembolization treatment to Ankara University School of Medicine Department of Nuclear Medicine.
Exclusion Criteria:
-
Patients with ECOG performance score >1
-
Claustrophobia
-
Life expectancy shorter than 3 months
-
Pregnant or breast-feeding patients
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Ankara University | Ankara | Turkey | 06590 |
Sponsors and Collaborators
- Ankara University
Investigators
- Principal Investigator: Cigdem Soydal, MD, Ankara University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- ARTE-MISO