Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging

• Sponsor: Assiut University (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT03214341
• Collaborator: (none)
• Enrollment: 24
• Location: 1
• Anticipated Duration (Months): 24.9
• Patients Per Site Per Month: 1

Study Details

Study Description

Brief Summary

Differentiation between benign and malignant mediastinal tumors as well as characterization and grading of malignancy which is essential for treatment planning as well as for prognosis

Condition or Disease	Intervention/Treatment	Phase
Mediastinal Tumor	Radiation: MRI diffusion

Detailed Description

Differentiation between benign and malignant mediastinal tumors as well as characterization and grading of malignancy is essential for treatment planning as well as for prognosis .

MRI presents valuable diagnostic information in assessing the mediastinum. In addition, special applications have been developed over recent years diffusion-weighted magnetic resonance imaging is one such technique The advent of echo-planar imaging technique has rendered diffusion weighted imaging of the abdomen and thoracic cavity possible .

Quantitative assessment of the mediastinal mass is possible by calculation of apparent diffusion co-efficient value ,which is related to the proportion of extracellular and intracellular component.

The apparent diffusion co-efficient is inversely correlated with tissue cellularity. It is lower in viable tumor tissue with densely packed diffusion-hindering obstacles than in tissue with less densely packed obstacles such as tumor necrosis and benign tissue .

Study Design

• Study Type: Observational
• Anticipated Enrollment: 24 participants
• Observational Model: Case-Crossover
• Time Perspective: Cross-Sectional
• Official Title: Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging
• Anticipated Study Start Date: Dec 1, 2017
• Anticipated Primary Completion Date: Dec 1, 2019
• Anticipated Study Completion Date: Dec 30, 2019

Outcome Measures

Primary Outcome Measures

1. sensitivity and specificity of magnetic resonance imaging diffusion in mediastinal masses [up to one month]

Eligibility Criteria

Criteria

• Ages Eligible for Study: N/A and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Any age groups

• diagnosis of mediastinal mass (by Multislice Computed Tomography).

Exclusion Criteria:

• chemotherapy radiotherapy.

• thoracic surgery.

• cystic mass .

• mass with large amount of necrosis or calcification.

• contraindication of MRI (e.g. pacemakers , claustrophobia).

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Assiut university	Assiut		Egypt

Sponsors and Collaborators

• Assiut University

Investigators

• Principal Investigator: Mostafa Thabet Hussein, professor, Assiut University

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

• the investigator had gained some information from this site

Publications

None provided.

• Responsible Party: Gehad Mohammed Safwat Ali, Principal Investigator, Assiut University
• ClinicalTrials.gov Identifier: NCT03214341
• Other Study ID Numbers: MRIML
• First Posted: Jul 11, 2017
• Last Update Posted: Jul 11, 2017
• Last Verified: Jul 1, 2017

• Individual Participant Data (IPD) Sharing Statement: Yes
• Plan to Share IPD: Yes
• Studies a U.S. FDA-regulated Drug Product: No
• Studies a U.S. FDA-regulated Device Product: No
• Keywords provided by Gehad Mohammed Safwat Ali, Principal Investigator, Assiut University: mediastinal masses; MRI diffusion
• Additional relevant MeSH terms: Mediastinal Neoplasms

Study Results

No Results Posted as of Jul 11, 2017