Assessment of Relationship Between Preoperative Nutritional Status and Perioperative/Postoperative Conditions in Patients With Lung Cancer Scheduled for Lobectomy
Study Details
Study Description
Brief Summary
Malnutrition is common in patients with lung cancer. In patients with malnutrition risk, the risk of complications is high both in the perioperative, early and late postoperative periods. Malnutrition is an independent risk factor for length of hospital stay and cost in these patients. Patients with lung cancer may have many morbidities in postoperative period, especially problems with wound healing. Therefore, assessment of the nutritional status of patients with lung cancer should begin at the diagnosis stage.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
In patients with lung cancer scheduled for lobectomy, anthropometric measurements will be measured and the results of laboratory tests(albumin, prealbumin, creatinine, total lymphocyte count, C reactive protein), Nutritional Risk Screening-2002, Nutritional Risk Index, Mini Nutritional Assessment, Glasgow Prognostic Score, Prognostic Nutritional Index and neoadjuvant chemotherapy or not will be recorded in 72 hours before surgery. In addition, demographic information of the patients (name, surname, identification number, age, comorbidity, American Society of Anesthesiologists score) will be recorded. After the information is given to the patients, their written and verbal consent will be obtained.
In the operating room, routine monitoring (electrocardiography, invasive blood pressure measurement, arterial blood gas monitoring, peripheral oxygen saturation, end-tidal carbon dioxide measurement by capnography) will be applied to the patients in accordance with the standard protocol for elective lobectomy surgery.
Hemodynamic changes (eg. dysrhythmia, hypotension, hypertension, hemorrhage), metabolic status (pH, bicarbonate, base excess), lactate, glucose level in blood gas evaluation and intraoperative complications will be recorded during the intraoperative period.
In the postoperative period, length of stay in the intensive care unit, length of hospital stay, early complications (eg. dysrhythmia, acute coronary syndrome, sepsis, mediastinitis, pneumonia, surgical site infection, prolonged air leak), time to start oral intake and transition to adequate oral intake will be recorded in the one-month postoperative period.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Lung cancer scheduled lobectomy
|
Diagnostic Test: Nutritional Risk Screening-2002
Nutritional Risk Screening-2002
Diagnostic Test: Nutritional Risk Index
Nutritional Risk Index
Diagnostic Test: Mini Nutritional Assessment
Mini Nutritional Assessment
Diagnostic Test: Glasgow Prognostic Score
Glasgow Prognostic Score
Diagnostic Test: Prognostic Nutritional Index
Prognostic Nutritional Index
Diagnostic Test: Anthropometric measurements
middle arm circumference
Device: Handgrip strength test
Handgrip strength test
|
Outcome Measures
Primary Outcome Measures
- Postoperative complications [a month after the surgery]
dysrhythmia, acute coronary syndrome, sepsis, mediastinitis, pneumonia, surgical site infection, prolonged air leak
- Length of stay in the intensive care unit [up to 30 days]
Length of stay in the intensive care unit
- Length of hospital stay [up to 30 days]
Length of hospital stay
- Intraoperative hemodynamic complications [during the procedure]
dysrhythmia, hypotension, hypertension, hemorrhage
Secondary Outcome Measures
- Oral intake [up to 30 days]
time to start oral intake and transition to adequate oral intake
- pH [during the procedure]
pH in arterial blood gas evaluation
- bicarbonate [during the procedure]
bicarbonate level in arterial blood gas evaluation
- base excess [during the procedure]
base excess in arterial blood gas evaluation
- lactate [during the procedure]
lactate level in arterial blood gas evaluation
- glucose [during the procedure]
glucose level in arterial blood gas evaluation
Eligibility Criteria
Criteria
Inclusion Criteria:
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Having a diagnosis of lung cancer
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Lung lobectomy operation will be performed
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18 years and older patients
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Having an American Society of Anesthesiologists score of 1, 2, 3
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Having approved and signed the informed consent form
Exclusion Criteria:
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Patients who underwent lobectomy with a diagnosis other than lung cancer
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Patients younger than 18 years
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Patients with an American Society of Anesthesiologists score of 4 and above
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Patients who did not accept informed consent
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Patients who refused to participate in the study
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Bursa Uludağ Üniversitesi Tıp Fakültesi | Bursa | Nilüfer | Turkey | 16000 |
Sponsors and Collaborators
- Turkish Society of Anesthesiology and Reanimation
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
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- Detsky AS, McLaughlin JR, Baker JP, Johnston N, Whittaker S, Mendelson RA, Jeejeebhoy KN. What is subjective global assessment of nutritional status? JPEN J Parenter Enteral Nutr. 1987 Jan-Feb;11(1):8-13.
- Kondrup J, Rasmussen HH, Hamberg O, Stanga Z; Ad Hoc ESPEN Working Group. Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials. Clin Nutr. 2003 Jun;22(3):321-36.
- McKenna NP, Bews KA, Al-Refaie WB, Colibaseanu DT, Pemberton JH, Cima RR, Habermann EB. Assessing Malnutrition Before Major Oncologic Surgery: One Size Does Not Fit All. J Am Coll Surg. 2020 Apr;230(4):451-460. doi: 10.1016/j.jamcollsurg.2019.12.034. Epub 2020 Feb 26.
- Neelemaat F, Kruizenga HM, de Vet HC, Seidell JC, Butterman M, van Bokhorst-de van der Schueren MA. Screening malnutrition in hospital outpatients. Can the SNAQ malnutrition screening tool also be applied to this population? Clin Nutr. 2008 Jun;27(3):439-46. doi: 10.1016/j.clnu.2008.02.002. Epub 2008 Apr 18.
- Vellas B, Guigoz Y, Garry PJ, Nourhashemi F, Bennahum D, Lauque S, Albarede JL. The Mini Nutritional Assessment (MNA) and its use in grading the nutritional state of elderly patients. Nutrition. 1999 Feb;15(2):116-22. Review.
- LungCancerMalnutrition