3D sono in RA: Assessment of Wrist Joint and Knee Joint Inflammation in Patients With Rheumatoid Arthritis by Quantitative Three Dimensional Power Doppler Ultrasonography

Sponsor

Taichung Veterans General Hospital (Other)

Overall Status

Completed

CT.gov ID

NCT00858169

Collaborator

(none)

Enrollment

Duration (Months)

Study Details

To investigate the wrist joint synovial blood flow intensity and model by quantitative three-dimensional (3D) power Doppler ultrasonography (PDUS) in patients with rheumatoid arthritis before and after initiation of a new medicine and compare these data with routinely used clinical data and laboratory findings, such as pain score, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)
To investigate the intra-observer and inter-observer agreement of quantitative 3D PDUS assessment of the vascularity in wrist joints and knee joints using automatic volume scan.

Condition or Disease	Intervention/Treatment	Phase
Rheumatoid Arthritis

Study Type:

Observational

Actual Enrollment :

49 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

Taichung Veterans General Hospital

Study Start Date :

Mar 1, 2009

Actual Primary Completion Date :

Mar 1, 2010

Actual Study Completion Date :

Mar 1, 2010

Correlation between 2D- and 3D-PDUS quantification data and clinical data, including pain score, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) [cross-sectional]

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Patients who fulfill the 1987 ARA criteria for RA
Patients with at least one painful swollen wrist or knee joint observed by a rheumatologist
Patients who will receive a new medicine, including oral corticosteroid, intravenous methylprednisolone pulse therapy, intraarticular injection with steroid or methotrexate, DMARDs, or biologic agent

Patients with active infection
Patients with concurrent malignant disease
Patients with a history of traumatic, septic, or cystal arthritis, previous joint surgery, or arthroscopic synovectomy of any wrist or kneejoint within the past 12 months before the study
Patients who have severe wrist or knee joint deformity that makes the US assessment protocol unable to complete