Factors Associated With Decisions to Withhold or Withdraw Intensive Care
Study Details
Study Description
Brief Summary
Medical and socioeconomic data are extracted from the Swedish Intensive Care Registry (SIR), the Swedish National Patient Registry and Statistics Sweden for all adult patients admitted to in Swedish intensive care units between 2014-01-01 and 2020-12-31 with a diagnosis of sepsis and/or acute respiratory distress syndrome (ARDS) and/or coronavirus 19 (COVID-19) infection, and registered in SIR. The impact of demographic and socioeconomic factors on decisions to withhold or withdraw intensive care, and on mortality, are studied and statistically adjusted for level of chronic comorbidity and severity of acute illness.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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Detailed Description
Patient identification and data acquisition With permission from the ethical board of Sweden, all registered intensive care episodes with a diagnosis of sepsis, acute respiratory distress syndrome (ARDS) or coronavirus 19 (COVID-19) and admission between 2014-01-01 and 2020-12-31 are identified in the Swedish Intensive Care Registry (SIR). Basic demographic data (age, sex) and intensive care data from SIR are combined with comorbidity data from the National Patient Registry of the Board of Health and Welfare (Socialstyrelsen), and data on country of birth, household size, education and economy from Statistics Sweden (SCB) to produce a pseudonymized study data set. For patients with multiple intensive care episodes, the first one is used.
Analysis Descriptive data on the frequency of decisions to withhold or withdraw intensive care, and on demographic and socioeconomic factors, morbidity and mortality in patients with or without such decisions, are produced. Logistic regression is used to assess the association between demographic and socioeconomic factors and limitations in intensive care, adjusting for acute and chronic morbidity and accounting for multicenter data. Secondarily, association between the same factors and mortality is studied.
Study Design
Outcome Measures
Primary Outcome Measures
- Decision to withhold or withdraw intensive care [During ICU care]
Registered decision
Secondary Outcome Measures
- 30 day mortality [30 days]
death within 30 days of ICU admission
- 90 day mortality [90 days]
death within 90 days of ICU admission
Eligibility Criteria
Criteria
Inclusion Criteria:
- Registered intensive care episode with relevant diagnosis
Exclusion Criteria:
- None, if inclusion criteria fulfilled
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Uppsala University, department of Surgical Sciences | Uppsala | Sweden | 75185 |
Sponsors and Collaborators
- Uppsala University
Investigators
- Principal Investigator: Miklós Lipcsey, MD, PhD, Upsala University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Uppsala University