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The Association Between Autoimmune or Inflammation and Thyroid Disease

Sponsor
Taichung Veterans General Hospital (Other)
Overall Status
Recruiting
CT.gov ID
NCT02886949
Collaborator
(none)
500
Enrollment
1
Location
157
Duration (Months)
3.2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study aims to evaluate the effects of thyroid functions on energy homeostasis and inflammation.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    The subjects were enrolled for evaluation of thyroid functions. The associations between thyroid function and energy homeostasis and inflammation will be assessed.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    500 participants
    Observational Model:
    Cohort
    Time Perspective:
    Prospective
    Official Title:
    The Relationship of Vascular Cell Adhesion Molecule 1, C-reactive Protein, Brain-derived Neurotrophic Factor, Orexin and Depressive Symptoms in the Subjects With Thyroid Disease
    Study Start Date :
    Nov 1, 2011
    Anticipated Primary Completion Date :
    Dec 1, 2020
    Anticipated Study Completion Date :
    Dec 1, 2024

    Outcome Measures

    Primary Outcome Measures

    1. brain-derived neurotrophic factor [3 months]

      BDNF

    Secondary Outcome Measures

    1. vascular cell adhesion molecule 1 (VCAM-1) [3 months]

      Inflammation

    2. C-reactive protein (CRP) [3 months]

      Inflammation

    3. Orexin [3 month]

      Psychological assessment

    4. Zung Self-Rating Depression Scale (Zung SDS) [3 month]

      Depressive symptom

    5. Body composition [3 month]

      fat component

    6. ankle brachial index (ABI) [3 months]

      Arterial stiffness

    7. pulse wave velocity (PWV) [3 months]

      Arterial stiffness

    8. mean arterial pressure (MAP) [3 months]

      Arterial stiffness

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:
    • Subjects visits outpatient department due to a suspicion of thyroid disease
    Exclusion Criteria:
    • Psychological disorders, severe inflammatory or infection diseases.

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital Taichang Taiwan 407

    Sponsors and Collaborators

    • Taichung Veterans General Hospital

    Investigators

    • Principal Investigator: I-Te Lee, MD, Taichung Veterans General Hospital

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Taichung Veterans General Hospital
    ClinicalTrials.gov Identifier:
    NCT02886949
    Other Study ID Numbers:
    • CE11307
    First Posted:
    Sep 1, 2016
    Last Update Posted:
    Jan 7, 2020
    Last Verified:
    Jan 1, 2020
    Individual Participant Data (IPD) Sharing Statement:
    No
    Plan to Share IPD:
    No
    Additional relevant MeSH terms:
    Thyroid Diseases
    Thyrotoxicosis

    Study Results

    No Results Posted as of Jan 7, 2020