ABCUCEOI: Association Between COVID-19 and UTIs Caused by ESBL Organism in Infants

Sponsor

Hamad Medical Corporation (Industry)

Overall Status

Not yet recruiting

CT.gov ID

NCT05630326

Collaborator

(none)

300

Enrollment

Location

Anticipated Duration (Months)

24.9

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Urinary tract infections (UTIs) in infants and young children are one of the most common bacterial infections, usually febrile illness without source, frequently due to Enterobacteriaceae, mainly Escherichia coli.

Multidrug-resistant organisms including extended-spectrum beta-lactamase (ESBL) producing bacteria are becoming more prevalent. Due to the risk factors of ESBL-producing organisms in community-acquired (CA)-UTIs in infants in QATAR and Arab countries are still not studied because of the limited therapeutic options. hence, the importance of this study is to get knowledge about how to decrease the rapidly increasing in ESBL- producing bacteria, in infants, and to use antibiotics in a suitable guideline.so, The aim of this retrospective case-control study is to determine the clinical manifestations, and investigations of urinary tract infections among infants and the association with COVID-19 infection, in pediatric emergency centers at Hamad General Hospital - Qatar. From 1st January 2015 till 1st January 2022.

Condition or Disease	Intervention/Treatment	Phase
Renal Insufficiency	Other: comparing, prevalence Other: assessment Other: association Other: evaluation

Detailed Description

In this retrospective, case-control study investigators will include all infants (0-1 year) with UTIs who were treated at Hamad General Hospital, pediatric division- PEC Doha, Qatar, using the electronic medical records from 1st January 2015 till January 1st, 2022, diagnosed by a positive urine culture. Investigators will look for the clinical manifestations, radiological and laboratory findings, renal scarring, ESBL-organisms, prevalence, median age, gender, and ethnic background. Participants are divided into two groups: early infancy and late infancy, ESBL UTIs and non-ESBL UTIs, and upper UTIs and lower UTIs. Finally, UTIs ESBL with COVID-19 and without COVID_19.

Study Design

Study Type:

Observational

Anticipated Enrollment :

300 participants

Observational Model:

Case-Control

Time Perspective:

Retrospective

Official Title:

Clinical, Laboratory, and Radiological Characteristics of Urinary Tract Infections in Infants With COVID-19

Anticipated Study Start Date :

Mar 1, 2023

Anticipated Primary Completion Date :

Mar 1, 2024

Anticipated Study Completion Date :

Mar 1, 2024

Arms and Interventions

Arm	Intervention/Treatment
ESBL UTI all infants with UTIs caused by ESBL producing organisms	Other: comparing, prevalence Comparing infants with UTIs caused by ESBL organism, or non ESBL organism. Other Names: Data on clinical and laboratory findings are reviewed from medical records for details
Non-ESBL UTI all infants with UTIs caused by non-ESBL producing organisms	Other: assessment comparing infants with UTIs caused by ESBL organism, or non ESBL organism.
ESBL UTI with COVID-19 all infants with UTIs caused by ESBL producing organisms with COVID-19 infection	Other: association comparing ESBLUTI with COVID-19 and ESBL UTI without COVID-19
ESBL UTI without COVID-19 all infants with UTIs caused by ESBL producing organisms without COVID-19 infection	Other: evaluation comparing ESBLUTI with COVID-19 and ESBL UTI without COVID-19