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Association Between Deficiency of MBL (Mannose-Binding Lectin) and Polymorphisms in MBL2 Gene to Urinary Tract Infection

Sponsor
HaEmek Medical Center, Israel (Other)
Overall Status
Completed
CT.gov ID
NCT00678028
Collaborator
(none)
200
Enrollment
1
Location

Study Details

Study Description

Brief Summary

Due to genetic polymorphism about 15%-30% of the world population have low levels of MBL (Mannose Binding Lectin) in serum (below 500ng/mL). Different studies reported correlation between polymorphism in the MBL gene with low levels of MBL in serum and higher frequency of recurrent infections, severity of sepsis, ARDS and other infections. Urinary Tract Infection (UTI) is one of the very common infection in women. Since MBL is part of the innate immunity and there are proofs of relation between patients with recurrent infections and lack of MBL, we decided to explore a possible relation between low levels of MBL and different genotypes of MBL in young women and the risk to develop recurrent UTI.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    200 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Prospective
    Official Title:
    Association Between Deficiency of MBL (Mannose-Binding Lectin) and Polymorphisms in MBL2 Gene to Urinary Tract Infection
    Study Start Date :
    Feb 1, 2008

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years to 50 Years
      Sexes Eligible for Study:
      Female
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:

      • women above 18 years old.

      • premenopausal

      • recurrent UTI

      Exclusion Criteria:

      • pregnancy

      • immunocompromised

      • active malignancy

      • HIV carrier

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Ha'Emek Medical Center Afula Israel 18101

      Sponsors and Collaborators

      • HaEmek Medical Center, Israel

      Investigators

      None specified.

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00678028
      Other Study ID Numbers:
      • 0080-07-EMC
      First Posted:
      May 15, 2008
      Last Update Posted:
      Apr 23, 2009
      Last Verified:
      Apr 1, 2009
      Keywords provided by , ,
      MBL, UTI
      Additional relevant MeSH terms:
      Infections
      Communicable Diseases
      Urinary Tract Infections

      Study Results

      No Results Posted as of Apr 23, 2009