The Association Between the Intraoperative Blood Pressure Changes and Whole Exome Genome

Sponsor

National Taiwan University Hospital (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT05730140

Collaborator

(none)

Enrollment

94.7

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

The intraoperative blood pressure changes have been important for postoperative morbidity and mortality. However, some patients did not occur intraoperative hypotension but some patients would have severe intraoperative hypotension. It may be associated with genome related. In this hypothesis, we aim to elucidate the association between the whole exome genome and intraoperaive blood pressure changes.

Condition or Disease	Intervention/Treatment	Phase
the Association Between the Arterial Stiffness, Intraoperative Blood Pressure Changes and Genetic Effect	Other: this study did not involve interventions; it only observational study

Detailed Description

We aim to elucidate the association between the whole exome genome and intraoperative blood pressure changes.

We will enroll patients older than 20 years old and undergo elective general anesthesia.

Before anesthesia, we will obtain blood sample for whole exome genome test and give arterial line for intraoperative monitor.

After completing surgery, we will follow the patients' all postoperative major organ function.

We hope this study to be able to give us the more information about the specific genetic effect on the arterial stiffness and intraoperative blood pressure changes.

Study Design

Study Type:

Observational

Anticipated Enrollment :

30 participants

Observational Model:

Case-Control

Time Perspective:

Cross-Sectional

Official Title:

Association Between Whole Exon Sequencing and Arterial Stiffness in Patients With Intraoperative Hypotension)

Anticipated Study Start Date :

Feb 10, 2023

Anticipated Primary Completion Date :

Dec 31, 2028

Anticipated Study Completion Date :

Dec 31, 2030

Arms and Interventions

Arm	Intervention/Treatment
patients undergoing general anesthesia patients undergoing general anesthesia	Other: this study did not involve interventions; it only observational study this study did not involve interventions. This study is an observational study for elucidating the intraoperative blood pressure changes, artierial stiffness, and whole exome genome

Arm

Intervention/Treatment

patients undergoing general anesthesia

Other: this study did not involve interventions; it only observational study

this study did not involve interventions. This study is an observational study for elucidating the intraoperative blood pressure changes, artierial stiffness, and whole exome genome

Outcome Measures

Primary Outcome Measures

The association between the arterial stiffness and whole exome genome [15 minutes]
using pearson correlation to describe the association

Eligibility Criteria

Criteria

Ages Eligible for Study:

20 Years to 90 Years

Sexes Eligible for Study:

All

Inclusion Criteria:

elective general surgery

Exclusion Criteria:

coagulopathy

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

National Taiwan University Hospital

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

National Taiwan University Hospital

ClinicalTrials.gov Identifier:

NCT05730140

Other Study ID Numbers:

202209125RINC

First Posted:

Feb 15, 2023

Last Update Posted:

Feb 15, 2023

Last Verified:

Feb 1, 2023

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Study Results

No Results Posted as of Feb 15, 2023