Association Between Molar-Incisor Hypomineralization, Maternal Stress and Anxiety: A Cross Sectional Study.

Sponsor
Cairo University (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT06081491
Collaborator
(none)
176
13

Study Details

Study Description

Brief Summary

Our aim is to mind the gap in research between the occurrence of MIH and its correlation with Stress and Anxiety.

Condition or Disease Intervention/Treatment Phase
  • Diagnostic Test: diagnosis

Detailed Description

MIH is a medical global condition characterized by qualitative enamel defect of one to four permanent first molars frequently associated with affected incisors, due to its increasing prevalence that is variable worldwide and its significant adverse effect even the simplest of the daily vital activities like brushing or eating way for our young patients' health besides negative social impact when incisors are also affected the analysis of etiological factors should be carried out.

Worldwide the prevalence of this condition, MIH was found to be from 2.4 to 40%, the reason behind this huge range difference is the use of different indices, diagnostic criteria, variability between examiners, lack of standardized methods of recording lesions and different age groups, while recent studies in Egypt reported 2.3% of MIH in a group of Egyptian children from 8 to 12 years in Cairo. Moreover, 878 million people across the world were MIH-affected and 17.5 million new cases are identified each year according to a study published 02 August 2022 in Egypt.

Despite the worldwide increasing interest in the causes of molar-incisor hypomineralization (MIH), there is still insufficient evidence to verify the aetiological factors of this condition especially stress and anxiety . There is a potential relationship between stress and MIH, as glucocorticoids mainly cortisol have receptors on ameloblasts and so further research and population based studies are urgently required to evaluate the prevalence of MIH and its association with stress.

Study Design

Study Type:
Observational
Anticipated Enrollment :
176 participants
Observational Model:
Other
Time Perspective:
Retrospective
Official Title:
Association Between Molar-Incisor Hypomineralization, Maternal Stress and Anxiety: A Cross Sectional Study.
Anticipated Study Start Date :
Sep 1, 2024
Anticipated Primary Completion Date :
Sep 1, 2025
Anticipated Study Completion Date :
Oct 1, 2025

Outcome Measures

Primary Outcome Measures

  1. Relation between stressful events and occurrence of MIH [baseline]

    Questionnaire(Brejawi MS etal .2022), Multiple choice questions

Secondary Outcome Measures

  1. Post natal factors 1. childhood measles 2. urinary tract infection 3. bronchitis 4. otitis media 5. gastric disorders 6. fever 7. kidney diseases 8. pneumonia 9. asthma 10. antibiotic use [baseline]

    Questions answered by the parents

Eligibility Criteria

Criteria

Ages Eligible for Study:
7 Years to 10 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • Pediatric Patients with completely erupted at least one first permanent molar

  • Children age range from 7 and 10 years

  • Parents who agree and signed the consent for their children participation

Exclusion Criteria:
  • Parents refuse their children to participate

  • Children above or below this average age.

  • Enamel defects only limited to the Permanent incisors

Contacts and Locations

Locations

No locations specified.

Sponsors and Collaborators

  • Cairo University

Investigators

  • Study Director: Soaad A Moniem, Proffesor, Cairo University

Study Documents (Full-Text)

None provided.

More Information

Additional Information:

Publications

Responsible Party:
Sarah Mahmoud Mohamed Sadek, Doctor, Cairo University
ClinicalTrials.gov Identifier:
NCT06081491
Other Study ID Numbers:
  • MIH and stress
First Posted:
Oct 13, 2023
Last Update Posted:
Oct 13, 2023
Last Verified:
Oct 1, 2023
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:

Study Results

No Results Posted as of Oct 13, 2023