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Association of Circulating Chemerin Levels and Arterial Stiffness

Sponsor
Korea University (Other)
Overall Status
Unknown status
CT.gov ID
NCT01293929
Collaborator
(none)
120
Enrollment
1
Location
28
Duration (Days)
130.4
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Chemerin is a novel adipokine that might provide a link between chronic inflammation and obesity. Pulse wave velocity(PWV) is a useful method for examining arterial stiffness, meaning early-stage atherosclerosis. Therefore, in the present study, the investigators examined the relationship between circulating chemerin and arterial stiffness measured using PWV in obese persons.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    120 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Cross-Sectional
    Study Start Date :
    Feb 1, 2011
    Anticipated Primary Completion Date :
    Mar 1, 2011
    Anticipated Study Completion Date :
    Mar 1, 2011

    Arms and Interventions

    Arm Intervention/Treatment
    Non- obese group
    Obese group

    Outcome Measures

    Primary Outcome Measures

    1. The difference of serum chemerin level between obese and non-obese groups [at the time of initial enrollment (4weeks)]

      serum chemerin levels of all participants were by determined by an enzyme-linked immunosorbent assay (ELISA) kit (Biovender Laboratory Medicine Inc., Modrice, Czech Republic)

    Secondary Outcome Measures

    1. The correlation of serum chemerin levels with arterial stiffness [at the time of enrollment (4 weeks)]

      Arterial stiffness was measure using a Colin Waveform Analyser (model BP-203RPE II; Colin, Komaki, Japan). It was expressed as branchial ankle pulswe wave velocity (baPWV)

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    20 Years to 80 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • Self referred persons for visiting routine medical check in our clinic
    Exclusion Criteria:

    • Malignancy

    • Severe renal or hepatic disease

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Hye Jin Yoo Seoul Korea, Republic of

    Sponsors and Collaborators

    • Korea University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    , ,
    ClinicalTrials.gov Identifier:
    NCT01293929
    Other Study ID Numbers:
    • A102065-1011-1070100
    First Posted:
    Feb 11, 2011
    Last Update Posted:
    Mar 4, 2011
    Last Verified:
    Jan 1, 2011
    Additional relevant MeSH terms:
    Atherosclerosis

    Study Results

    No Results Posted as of Mar 4, 2011