SA1PLG: The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders
Study Details
Study Description
Brief Summary
Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing periodontitis.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
periodontitis is a polymicrobial inflammatory disease caused by various modifiable and non-modifiable risk factors. the non-modifiable risk factors include genetic polymorphisms like the gene coding for alpha-1-antitrypsinase
COPD is a chronic inflammatory disease characterized by deterioration of lung function due to loss of elasticity of the lungs.
SERPINA1 gene product has a protective role on the connective tissue components of both lungs and gums.
Hence, this study tries to determine if the gene polymorphism in COPD serves as a risk factor for developing periodontitis.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| SERPINA1 gene in COPD and periodontitis patients aged between 30-70 yrs with COPD (satisfying Gold's criteria) and chronic periodontitis (>4mm pocket probing depth) |
Genetic: SERPINA1 gene
2ml blood sample collected from patients to extract DNA for assessment of SERPINA1 gene polymorphism
Other Names:
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Outcome Measures
Primary Outcome Measures
- SERPINA1 gene polymorphism [9 months]
of blood samples and running samples by PCR
Eligibility Criteria
Criteria
Inclusion Criteria:
- Male and female patients aged between 30-70yrs diagnosed with COPD and chronic periodontitis who are willing to participate in the study.
Exclusion Criteria:
-
Pateints with other systemic disorders
-
patients not willing to participate in the study
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Dr. Sneha Agarwal PG(periodontics) | Hyderabad | Telangana | India | 500034 |
Sponsors and Collaborators
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Investigators
- Principal Investigator: Dr. Sneha Agarwal, PG(perio), Panineeya Mahavidyalaya institute of dental sciences and research centre
Study Documents (Full-Text)
None provided.More Information
Publications
- Scott DA, von Ahsen N, Palmer RM, Wilson RF. Analysis of two common alpha 1-antitrypsin deficiency alleles (PI*Z and PI*S) in subjects with periodontitis. J Clin Periodontol. 2002 Dec;29(12):1118-21.
- Travis J, Pike R, Imamura T, Potempa J. The role of proteolytic enzymes in the development of pulmonary emphysema and periodontal disease. Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 2):S143-6. Review. Erratum in: Am J Respir Crit Care Med 1995 Mar;151(3 Pt 1):926.
- D149206031