The Effect of Oral Zinc Supplementation on Thiol Oxido-reductive Index
Study Details
Study Description
Brief Summary
Although several studies have considered the relationship between infertility and semen thiol compounds levels, no study on the effects of asthenospermia treatments such as oral zinc supplementation on thiol related enzymes activity which are important in fertility of the individual has been reported.
Condition or Disease | Intervention/Treatment | Phase |
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|
Phase 2 |
Detailed Description
The present study was conducted to study the effect of zinc supplementation on the quantitative and qualitative characteristics of semen along with reduced thiol, oxidized thiol and thiol related enzymes in the seminal plasma of asthenospermic patients.
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Experimental: Zinc sulfate 60 subfertile (age 32.5±3.23 year) men with asthenozoospermia was treated with zinc sulfate,every participant took two capsules of zinc sulfate per day for three months (each one 220 mg). |
Dietary Supplement: zinc sulfate
The subfertile group treated with zinc sulfate, every participant took two capsules of zinc sulfate per day for three months (each one 220 mg).
|
No Intervention: Healthy control 60 fertile (age 31.6±3.3 year) men, no treatment |
Outcome Measures
Primary Outcome Measures
- Thiol oxido-reductive index levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Thiol oxido-reductive index levels. [up to three months.]
Secondary Outcome Measures
- Glutathione peroxidase activity levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Glutathione peroxidase activity levels. [up to three months.]
- Sulfhydryl oxidase activity levels in spermatozoa and seminal plasma. The investigators evaluated the effects of zinc sulfate (220 mg/d) supplementation on Sulfhydryl oxidase activity levels. [up to three months.]
Eligibility Criteria
Criteria
Inclusion Criteria:
- The presence of asthenozoospermia in the semen sample.
Exclusion Criteria:
- The absence of endocrinopathy, varicocele, and female factor infertility. Smokers and alcoholic men were excluded from the study because of their recognized high seminal ROS levels and decreased antioxidant levels.
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Mahmoud Hadwan | Hilla | Babylon | Iraq | 51002 |
Sponsors and Collaborators
- mahmoud hussein hadwan
- Ministry of Health, Iraq
Investigators
- Principal Investigator: Mahmoud Hadwan, PhD, Babylon University
- Study Director: L Almashhedy, PhD, Babylon University
- Study Chair: Alsalman Abdulrrazaq, PhD, Babylon University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- Babil-4