Adult Arm of DZL All Age Asthma Cohort (ALLIANCE)

Sponsor

LungenClinic Grosshansdorf (Other)

Overall Status

Recruiting

CT.gov ID

NCT02419274

Collaborator

German Center for Lung Research (Other), Research Center Borstel (Other)

350

Enrollment

Locations

105

Duration (Months)

175

Patients Per Site

1.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Deep Phenotyping of adult asthma patients:

severity from mild to severe
both atopic and non-atopic
both childhood and adult onset
both smokers and non-smokers
corresponding pediatric cohort (Pediatric Arm of DZL All Age Asthma Cohort) with equivalent SOPs regarding collection of biomaterial and clinical data incl. lung function, further processing of biomaterial and further analyses

Condition or Disease	Intervention/Treatment	Phase
Asthma

Detailed Description

The clinical heterogeneity of asthma patients has been increasingly recognised within the last years. Recent studies and articles highlighted the idea of asthma not beeing a single disease but rather a unifying term for multiple phenotypes. Phenotype in this sense is defined as the combination of observable properties of an organism, that are produced by the interactions of a genotype and the environment. In contrast, endotype describes a specific underlying pathophysiological pathway. Linking asthma phenotypes and endotypes in a system biological approach is an important research goal in order to develop targeted therapy, especially for severe asthma.

The advantage the investigators' cohort provides is the collaboration with an equivalent pediatric cohort. In this setting questions regarding disease onset, exacerbation and chronicity can be posed and worked with in a comprehensive manner.

Study Design

Study Type:

Observational [Patient Registry]

Anticipated Enrollment :

350 participants

Observational Model:

Cohort

Time Perspective:

Prospective

Official Title:

The All Age Asthma Cohort (ALLIANCE) of the German Center for Lung Research (DZL), Adult Arm

Study Start Date :

Mar 1, 2014

Anticipated Primary Completion Date :

Oct 1, 2022

Anticipated Study Completion Date :

Dec 1, 2022

Outcome Measures

Primary Outcome Measures

Defining clinical asthma phenotypes by combining clinical, lung function and biomaterial data [2 years]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 99 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Proven Diagnosis according to current GINA Guideline (2014)
Ability to read and understand German
Ability to understand and agree to informed consent

Exclusion Criteria:

History of respiratory tract infection within the last 4 weeks before inclusion

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Research Center Borstel	Borstel		Germany	23845
2	LungenClinic Grosshansdorf	Grosshansdorf		Germany	22927

Sponsors and Collaborators

LungenClinic Grosshansdorf
German Center for Lung Research
Research Center Borstel

Investigators

Principal Investigator: Klaus F Rabe, MD PhD, LungenClinic Grosshansdorf, Grosshansdorf, Germany
Principal Investigator: Susanne Krauss-Etschmann, PhD, Research Center Borstel, Borstel, Germany