Genetic Determinants of the Response to Salbutamol Among Asthma Patients

• Sponsor: Hadassah Medical Organization (Other)
• Overall Status: Unknown status
• CT.gov ID: NCT00162396
• Collaborator: (none)
• Enrollment: 150
• Location: 1

Study Details

Study Description

Brief Summary

The response to salbutamol varies greatly among individuals. Data from previous studies indicate that some of the variability is accounted for by genetic polymorphisms in the gene encoding for the adrenoceptor subtype β2. The current study was designed to evaluate variability in the response to salbutamol among recently diagnosed patients who have not been treated by β2 agonists or corticosteroids.

Lung function tests will be performed prior to and following a single dose administration of salbutamol through inhalation. Additional pharmacodynamic indices will be monitored including pulse and blood pressure. Three samples of plasma will be drawn for the evaluation of salbutamol plasma concentration.

Condition or Disease	Intervention/Treatment	Phase
Asthma	Drug: Albuterol	N/A

Study Design

• Study Type: Interventional
• Anticipated Enrollment: 150 participants
• Allocation: Non-Randomized
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Official Title: Evaluation of Genetic Factors That May Account for Variability in the Response to Salbutamol Among Patients Suffering From Asthma
• Study Start Date: Aug 1, 1999

Outcome Measures

Primary Outcome Measures

1. Change in lung function tests after salbutamol inhalation []

2. Change in blood pressure and pulse after salbutamol inhalation []

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• 18 years and older

• Recently diagnosed as asthmatic

Exclusion Criteria:

• Current treatment by β2 agonist

• Current treatment by corticosteroids

• Acute asthma attack

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Hadassah Medical Organization	Jerusalem		Israel	91120

Sponsors and Collaborators

• Hadassah Medical Organization

Investigators

• Principal Investigator: Yoseph Caraco, MD, Hadassah Medical Organization

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT00162396
• Other Study ID Numbers: yc195511-HMO-CTIL
• First Posted: Sep 13, 2005
• Last Update Posted: Oct 29, 2008
• Last Verified: Oct 1, 2008

• Keywords provided by , ,: Albuterol; β2 Adrenergic receptor; Polymorphism
• Additional relevant MeSH terms: Asthma; Albuterol

Study Results

No Results Posted as of Oct 29, 2008