Intravenous Microdose Pharmacokinetic (PK) Study With [14C]-GSK2239633

Sponsor

GlaxoSmithKline (Industry)

Overall Status

Completed

CT.gov ID

NCT01086462

Collaborator

(none)

Enrollment

Location

Arm

1.1

Actual Duration (Months)

5.7

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This study is a first administration to man microdose study to describe the pharmacokinetics of GSK2239633.

Condition or Disease	Intervention/Treatment	Phase
Asthma	Drug: GSK2239633	Phase 1

Detailed Description

The different shapes of the pharmacokinetic (PK) profiles following administration of GSK2239633 in rat and dog make it difficult to reliably predict the human PK profile. This microdose study will provide an early readout on the distribution and clearance profile of the drug in man and will be used to model potential clinical oral doses. The study will be conducted using an open-label, single dose design in one group of healthy male volunteers. Each subject will receive a single intravenous infusion of 100ug GSK2239633 (containing approximately 10kBq of [14C]-GSK2239633), administered over 15 minutes. Subjects will attend for a screening visit within 30 days prior to Day 1 and receive a single dose infusion of study drug on Day 1. Blood and urine samples will be taken over 48 hours for pharmacokinetic and total radioactivity analysis, and safety and tolerability will be monitored. Subjects will be discharged on Day 3 and a follow-up telephone call will be made 4-10 days post-dose.

Study Design

Study Type:

Interventional

Actual Enrollment :

6 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Other

Official Title:

A Microdose Study to Describe the Intravenous Pharmacokinetics of [14C]-GSK2239633 in Healthy Male Subjects

Actual Study Start Date :

Jan 21, 2010

Actual Primary Completion Date :

Feb 22, 2010

Actual Study Completion Date :

Feb 22, 2010

Arms and Interventions

Arm	Intervention/Treatment
Experimental: GSK2239633 Single dose infusion of study drug over 15 minutes	Drug: GSK2239633 100 ug GSK2239633 containing approximately 10kBq [14C]-GSK2239633

Arm

Intervention/Treatment

Experimental: GSK2239633

Single dose infusion of study drug over 15 minutes

Drug: GSK2239633

100 ug GSK2239633 containing approximately 10kBq [14C]-GSK2239633

Outcome Measures

Primary Outcome Measures

Pharmacokinetics (AUC0-inf, Cmax, AUC0-t, t1/2, clearance, volume of distribution) of [14C]-GSK2239633 and total drug-related material [48 hours]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 50 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Healthy subjects are defined as individuals who in the opinion of the Investigator are free from clinically significant cardiac, pulmonary, gastrointestinal, hepatic, renal, haematological, endocrine, neurological and psychiatric disease or malignancy as determined by medical history, physical examination, laboratory studies, and other tests (including ECG). Subjects with values outside the normal range which are deemed to be clinically relevant should always be excluded from enrollment.
Male between 18 and 50 years of age inclusive, at the time of signing the informed consent.
Subject must agree to use one of the contraception methods listed in Section 8.1. of the protocol. This criterion must be followed from the time of screening until 90 days after the follow up
Body weight >or= 50 kg and BMI within range 18.5-29.9 kg/m2 (inclusive).
Capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form
Single QTcF <450 msec; or QTcF <480 msec in subjects with Bundle Branch Block
Lifelong non-smokers or ex-smokers of greater than 6 months and <5 pack year history. Pack years = (cigarettes per day smoked/20) x number of years smoked.
AST, ALT, alkaline phosphatase and bilirubin <or=1.5 ULN (isolated bilirubin >1.5 x ULN acceptable if bilirubin is fractionated and direct bilirubin <35%)

Exclusion Criteria:

A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody within 3 months of screening
Current or chronic history of liver disease, or known hepatic or biliary abnormalities
A positive pre-study drug/alcohol screen
A positive test for HIV antibody
History of regular alcohol consumption within 6 months of study defined as an average weekly intake of >12 units/week for males. One unit is equivalent to 8g of alcohol; a half-pint (~250ml) of beer, 1 glass (100ml) of wine or 1 (35 ml) measure of spirits.
Urinary cotinine levels indicative of smoking or history or regular use of tobacco- or nicotine-containing products (including snuff, nicotine-containing gum) within 6 months prior to screening
The subject has participated in a clinical trial and has received an investigational product within the following time period prior to first dosing: 60 days, 5 half-lives or twice the duration of the biological effect of investigational product (whichever is longer)
Exposure to more than four new chemical entities within 12 months prior to the first dosing day
Participation in a clinical trial involving administration of 14C-labelled compounds within last 12 months
Use of prescription or non-prescription drugs, including vitamins, herbal and dietary supplements (including St John's Wort) within 14 days or 5 half-lives prior to the first dose of study medication, unless in the opinion of the Investigator and Medical Monitor the medication will not interfere with study procedures or compromise subject safety.
History of sensitivity to any of the study medications, or components thereof or a history of drug or other allergy that, in the opinion of the investigator or GSK Medical Monitor, contraindicates their participation
Where participation in the study would result in donation of blood or blood products in excess of 500 mL within a 56 day period
Unwillingness or inability to follow procedures outlined in the protocol
Subject is mentally or legally incapacitated
A calculated creatinine clearance (Cockroft and Gault formula) of <90 mL/min
History of sensitivity to heparin or heparin-induced thrombocytopenia
Consumption of red wine, seville oranges, grapefruit or grapefruit juice from 7 days prior to the first dose of study medication