Clincosm LogoSign in Get a demo

Patients With Asymptomatic Hyperuricemia Have Stronger Local Inflammatory Response and Worse Outcome After Total Knee Arthroplasty

Sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University (Other)
Overall Status
Not yet recruiting
CT.gov ID
NCT05476367
Collaborator
(none)
614
Enrollment
1
Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

We identify all patients who had undergone primary total knee arthroplsty(TKA) from April 1, 2015, to March 30, 2016. Patients are grouped by uric acid level. The knee society score(KSS score) and the hospital for special surgery knee score (HSS score) before the surgery and 6 years after the surgery will be collected. Also the clinical data will be collected.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    614 participants
    Observational Model:
    Case-Control
    Time Perspective:
    Retrospective
    Official Title:
    Patients With Asymptomatic Hyperuricemia Have Stronger Local Inflammatory Response and Worse Outcome After Total Knee Arthroplasty
    Anticipated Study Start Date :
    Aug 1, 2022
    Anticipated Primary Completion Date :
    Sep 1, 2022
    Anticipated Study Completion Date :
    Sep 1, 2022

    Arms and Interventions

    Arm Intervention/Treatment
    patients with normal uric acid level

    The uric acid level is below 420 μmol/L in men and 360 μmol/L in women
    patients with high uric acid level

    The uric acid level is higher than 420 μmol/L in men and 360 μmol/L in women.

    Outcome Measures

    Primary Outcome Measures

    1. CRP [within 7 days after surgery]

      C-reactive protein

    2. temperature [within 7 days after surgery]

      The nurses measured the body temperature by Non-contact Ear Thermometer. The temperatures were measured at 6 am, 14 pm, and 18 pm every day, and the patients were kept admitted till day 5. The highest one was chosen for analysis.

    3. HSS score [6 years after surgery]

      the hospital for special surgery knee score

    4. KSS scores [6 years after surgery]

      knee society score

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years to 85 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • patients who had undergone primary TKA from April 1, 2015, to March 30, 2016
    Exclusion Criteria:
    • (1) infection, (2) rheumatoid arthritis, (3) ankylosing spondylitis, (4) revision surgery, (5) patients with unicondylar knee replacement, (6) patients who have been diagnosed with gout or previous gouty symptoms, and (7) patients combined with preoperative redness or swelling.

    Contacts and Locations

    Locations

    No locations specified.

    Sponsors and Collaborators

    • Second Affiliated Hospital, School of Medicine, Zhejiang University

    Investigators

    None specified.

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Second Affiliated Hospital, School of Medicine, Zhejiang University
    ClinicalTrials.gov Identifier:
    NCT05476367
    Other Study ID Numbers:
    • 2021-0785
    First Posted:
    Jul 27, 2022
    Last Update Posted:
    Jul 27, 2022
    Last Verified:
    Jul 1, 2022
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Additional relevant MeSH terms:
    Hyperuricemia

    Study Results

    No Results Posted as of Jul 27, 2022