Astaxanthin Supplementation in Cyclists

Sponsor

Maastricht University Medical Center (Other)

Overall Status

Unknown status

CT.gov ID

NCT01241877

Collaborator

(none)

Enrollment

Location

Arms

Study Details

Study Description

Brief Summary

Background of the study:

Astaxanthin has been shown to be a powerfull anti-oxidant. Health benefits have been shown in animals and humans. Exercise enhancing effects have been shown in animals via enhancement of fat oxidation. We want to examine the effects of 4 weeks of astaxanthin supplementation on fat oxidation and cycling performance in trained cyclists

Objective of the study:

To test the hypothesis that 4 weeks supplementation with astaxanthin will improve fat oxidation and improve exercise performance in trained cyclists

Study design:

Double blind, placebo controlled study.

Study population:

Well trained cyclists between 18-30 years old

Intervention (if applicable):

astaxanthin (20 mg/day) or placebo for 4 weeks

Primary study parameters/outcome of the study:

performance on a time trial after 90 min steady state exercise.

Secundary study parameters/outcome of the study (if applicable):

substrate use plasma glucose plasma lactate plasma free fatty acid plasma astaxanthin

Nature and extent of the burden and risks associated with participation, benefit and group relatedness (if applicable):

The risks involved in participating in this experiment are minimal. Astaxanthin has been shown to be safe. Insertion of the catheters in a vein is comparable to a normal blood draw and the only risk is of a small local haematoma.

Condition or Disease	Intervention/Treatment	Phase
Athletic Performance	Dietary Supplement: astaxanthin Dietary Supplement: placebo	N/A

Study Design

Study Type:

Interventional

Anticipated Enrollment :

24 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Masking:

Double (Participant, Investigator)

Primary Purpose:

Basic Science

Study Start Date :

Nov 1, 2010

Anticipated Primary Completion Date :

Jun 1, 2011

Arms and Interventions

Arm	Intervention/Treatment
Experimental: astaxanthin	Dietary Supplement: astaxanthin astaxanthin
Placebo Comparator: placebo	Dietary Supplement: placebo placebo

Arm

Intervention/Treatment

Experimental: astaxanthin

Dietary Supplement: astaxanthin

astaxanthin

Placebo Comparator: placebo

Dietary Supplement: placebo

placebo

Outcome Measures

Primary Outcome Measures

time trial performance [4 weeks]
time trial performance

Secondary Outcome Measures

substrate use [4 weeks]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 30 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

Healthy
Male
Age between 18 and 30 years
Endurance trained (≥3 sessions of endurance exercise per week)
VO2 max ≥ 50 ml/kg/min
Training history of more than one year of ≥3 sessions of endurance exercise per week
BMI <25 kg/m2

Exclusion Criteria:

Use of medication
Smoking

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Maastricht University	Maastricht	LI	Netherlands	6229

Sponsors and Collaborators

Maastricht University Medical Center

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

, ,

ClinicalTrials.gov Identifier:

NCT01241877

Other Study ID Numbers:

MEC 10-3-068

First Posted:

Nov 16, 2010

Last Update Posted:

Apr 20, 2011

Last Verified:

Apr 1, 2011

Study Results

No Results Posted as of Apr 20, 2011