Lung-MAP: Talazoparib in Treating Patients With HRRD Positive Recurrent Stage IV Squamous Cell Lung Cancer

• Sponsor: Southwest Oncology Group (Other)
• Overall Status: Completed
• CT.gov ID: NCT03377556
• Collaborator: National Cancer Institute (NCI) (NIH)
• Enrollment: 51
• Locations: 1157
• Arm: 1
• Actual Duration (Months): 49.4
• Patients Per Site: 0
• Patients Per Site Per Month: 0

Study Details

Study Description

Brief Summary

This phase II trial studies how well talazoparib works in treating patients with homologous recombination repair deficiency (HRRD) positive stage IV squamous cell lung cancer that has come back after previous treatment. Talazoparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Condition or Disease	Intervention/Treatment	Phase
ATM Gene Mutation; ATR Gene Mutation; BARD1 Gene Mutation; BRCA1 Gene Mutation; BRCA2 Gene Mutation; BRIP1 Gene Mutation; CHEK1 Gene Mutation; CHEK2 Gene Mutation; FANCA Gene Mutation; FANCC Gene Mutation; FANCD2 Gene Mutation; FANCF Gene Mutation; FANCM Gene Mutation; NBN Gene Mutation; PALB2 Gene Mutation; RAD51 Gene Mutation; RAD51B Gene Mutation; RAD54L Gene Mutation; Recurrent Squamous Cell Lung Carcinoma; RPA1 Gene Mutation; Stage IV Squamous Cell Lung Carcinoma AJCC v7	Other: Laboratory Biomarker Analysis; Other: Pharmacological Study; Drug: Talazoparib	Phase 2

Detailed Description

PRIMARY OBJECTIVES:

1. To evaluate the overall response rate (ORR) (confirmed and unconfirmed, complete and partial) with talazoparib (BMN 673) in HRRD Medivation (MDVN)-positive patients.

SECONDARY OBJECTIVES:

1. To evaluate investigator assessed progression-free survival (IA-PFS) and overall survival (OS) associated with therapy in HRRD MDVN-positive patients.

2. To evaluate ORR, IA-PFS, and OS in HRRD Foundation Medicine, Inc. (FMI)-positive patients.

3. To evaluate ORR in HRRD MDVN-negative/HRRD FMI-positive patients. IV. To evaluate the frequency and severity of toxicities associated with talazoparib (BMN 673) in HRRD FMI-positive patients.

TERTIARY OBJECTIVES:

1. To assess if the homologous recombination deficiency (HRD) score is associated with clinical outcomes (response, PFS, OS) in HRRD FMI-positive patients treated with talazoparib (BMN 673).

2. To assess if the level of PARP protein expression determined by immunohistochemistry is associated with clinical outcomes (response, PFS, OS) in HRRD FMI-positive patients treated with talazoparib (BMN 673).

3. To characterize pharmacokinetic properties of talazoparib (BMN 673).

OUTLINE:

Patients receive talazoparib orally (PO) once daily (QD) on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 3 months for 1 year, every 6 months for 2 years, and at the end of year 3.

Study Design

• Study Type: Interventional
• Actual Enrollment: 51 participants
• Allocation: N/A
• Intervention Model: Single Group Assignment
• Masking: None (Open Label)
• Primary Purpose: Treatment
• Official Title: A Phase II Study of Talazoparib (BMN 673) in Patients With Homologous Recombination Repair Deficiency Positive Stage IV Squamous Cell Lung Cancer (Lung-Map Sub-Study)
• Actual Study Start Date: Mar 3, 2017
• Actual Primary Completion Date: Jan 10, 2021
• Actual Study Completion Date: Apr 16, 2021

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Treatment (talazoparib) Patients receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.	Other: Laboratory Biomarker Analysis; Correlative studies; Other: Pharmacological Study; Correlative studies; Drug: Talazoparib; Given PO; Other Names: BMN 673 BMN-673

Outcome Measures

Primary Outcome Measures

1. Overall Response Rate Assessed by Response Evaluation Criteria in Solid Tumors 1.1 in HRRD-positive (MDVN) Participants [Up to 3 years post sub-study registration]

   The percentage of participants with confirmed and unconfirmed, partial response and complete response to treatment with talazoparib per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1). Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) for target lesions and assessed by MRI or CT: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR Analysis was performed using a more restricted definition of homologous recombination repair deficiency (HRRD)-positivity (Medivation [MDVN] criteria; defined by alterations in ATM/ATR/BRCA1/BRCA2/PALB2 genes). With 40 HRRD subset positive patients, overall response rate can be estimated within 13% with 95% confidence.

Secondary Outcome Measures

1. Investigator-assessed Progression-free Survival (IA-PFS) in HRRD-positive (MDVN) Participants [Up to 3 years post sub-study registration]

   From date of sub-study registration to date of first documentation of progression assessed by local review or symptomatic deterioration or death due to any cause. Participants last known to be alive without report of progression were censored at date of last disease assessment. Analysis was performed using a more restricted definition of homologous recombination repair deficiency (HRRD)-positivity (Medivation [MDVN] criteria; defined by alterations in ATM/ATR/BRCA1/BRCA2/PALB2 genes).

2. Overall Survival (OS) in HRRD-positive (MDVN) Participants [Up to 3 years post sub-study registration]

   From date of sub-study registration to date of death due to any cause. Participants last known to be alive were censored at date of last contact. Analysis was performed using a more restricted definition of homologous recombination repair deficiency (HRRD)-positivity (Medivation [MDVN] criteria; defined by alterations in ATM/ATR/BRCA1/BRCA2/PALB2 genes).

3. Overall Response Rate Assessed by Response Evaluation Criteria in Solid Tumors 1.1 in HRRD-positive (FMI) Participants [3 years post sub-study registration]

   The percentage of participants with confirmed and unconfirmed, partial response and complete response to treatment with talazoparib per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1). Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) for target lesions and assessed by MRI or CT: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR Analysis was performed using a broader definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc. [FMI] criteria; defined by alterations in ATM/ATR/BARD1/BRCA1/BRCA2/BRIP1/CHEK1/CHEK2/FANCA/FANCC/FANCD2/FANCF/FANCM/NBN(NBS1)/PALB2/RAD51/RAD51B(RAD51L1)/RAD54L/RPA1 genes).

4. Investigator-assessed Progression Free Survival (IA-PFS) FEP in HRRD-positive (FMI) Participants [3 years post sub-study registration]

   From date of sub-study registration to date of first documentation of progression assessed by local review or symptomatic deterioration or death due to any cause. Participants last known to be alive without report of progression were censored at date of last disease assessment. Analysis was performed using a broader definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc. [FMI] criteria; defined by alterations in ATM/ATR/BARD1/BRCA1/BRCA2/BRIP1/CHEK1/CHEK2/FANCA/FANCC/FANCD2/FANCF/FANCM/NBN(NBS1)/PALB2/RAD51/RAD51B(RAD51L1)/RAD54L/RPA1 genes).

5. Overall Survival (OS) in HRRD-positive (FMI) Participants [3 years post sub-study registration]

   From date of sub-study registration to date of death due to any cause. Participants last known to be alive were censored at date of last contact. Analysis was performed using a broad definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc. [FMI] criteria; defined by alterations in ATM/ATR/BARD1/BRCA1/BRCA2/BRIP1/CHEK1/CHEK2/FANCA/FANCC/FANCD2/FANCF/FANCM/NBN(NBS1)/PALB2/RAD51/RAD51B(RAD51L1)/RAD54L/RPA1 genes).

6. Duration of Response in HRRD-positive (FMI) Participants [Up to 3 years]

   From date of documentation of response (complete or partial) to date of first documentation of progression assessed by local review or symptomatic deterioration or death due to any cause among participants who achieve a complete or partial response.

7. Overall Response Rate Assessed by Response Evaluation Criteria in Solid Tumors 1.1 in HRRD-negative Per MDVN But HRRD-positive Per FMI Participants [3 years post sub-study registration]

   The percentage of participants with confirmed and unconfirmed, partial response and complete response to treatment with talazoparib per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1). Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) for target lesions and assessed by MRI or CT: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR Analysis was performed on participants that meet a broader definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc.) but not the stricter definition set by MDVN. [FMI] criteria; defined by alterations in ATM/ATR/BARD1/BRCA1/BRCA2/BRIP1/CHEK1/CHEK2/FANCA/FANCC/FANCD2/FANCF/FANCM/NBN(NBS1)/PALB2/RAD51/RAD51B(RAD51L1)/RAD54L/RPA1 genes).

8. Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs [Duration of treatment and follow up until death or 3 years post registration]

   Adverse Events (AEs) are reported by CTCAE Version 4.0. Only adverse events that are possibly, probably or definitely related to study drug are reported.

Other Outcome Measures

1. Homologous Recombination Deficiency (HRD) Immunohistochemistry Score [Up to 3 years]

   A logistic regression model will be used as both a continuous variable and categorized as high versus low. A Cox regression model will be used to assess associations with progression free survival and overall survival.

2. PARP Protein Expression Levels Assessed by Immunohistochemistry [Up to 3 years]

   A logistic regression model will be used to evaluate if HRD score (as both a continuous variable and categorized as high versus low) and PARP protein expression levels are associated with response. Similarly, a Cox regression model will be used to assess associations with progression free survival and overall survival.

Eligibility Criteria

Criteria

• Ages Eligible for Study: N/A and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No

Inclusion Criteria:

• Patients must meet all SCREENING/PRE-SCREENING and SUB-STUDY REGISTRATION COMMON ELIGIBILITY CRITERIA as specified in S1400: Phase II/III Biomarker-Driven Master Protocol for Previously Treated Squamous Cell Lung Cancer (Lung-Map)

• Patients must be assigned to S1400G; S1400G biomarker eligibility defined as homologous recombination repair deficiency (HRRD) positive is as follows

• Biomarker-positive group

• HRRD by FMI

• Homologous recombination repair deficiency by Foundation Medicine Inc., criteria

• Alteration type

• Truncating mutation, frameshift deletions, indels missense and nonsense mutations predicted to have functional consequence in any of the specified genes

• Eligible alteration

• Mutation in any one of the following critical HRR pathway genes: ATM, ATR, BARD1, BRCA1, BRCA2, BRIP1, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCF, FANCM, NBN (NBS1), PALB2, RAD51, RAD51B (RAD51L1), RAD54L, RPA1

• Patients must not have had prior exposure to any agent with a PARP inhibitor (e.g., veliparib, olaparib, rucaparib, niraparib, talazoparib [BMN 673]) as its primary pharmacology

• Patients must have achieved stable disease, a partial response, or a complete response at their first disease assessment after initiating first-line platinum-based chemotherapy; patients determined to have progressed (in the opinion of the treating physician) at their first disease assessment are not eligible

• Patients may not have any impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of talazoparib (BMN 673) (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, small bowel resection, or active peptic ulcer disease); patients must not have active small or large intestine inflammation such as Crohn's disease or ulcerative colitis (within 12 months of sub-study registration)

• Patients must be able to take oral medications; patients must be able to swallow capsules whole without crushing or altering them in any way

• Patients must not be taking, nor plan to take while on protocol treatment strong P-glycoprotein (P-gp) inhibitors, P-gp inducers, or breast cancer resistance protein (BCRP) inhibitors; the language ?P-gp or BCRP inhibitors or inducers? is reworded to ?strong P-gp inhibitors, P-gp inducers, or BCRP inhibitors? for consistency with the investigator brochure

• Patients must agree to have blood specimens submitted for pharmacokinetic analysis

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	University of Alabama at Birmingham Cancer Center	Birmingham	Alabama	United States	35233
2	Anchorage Associates in Radiation Medicine	Anchorage	Alaska	United States	98508
3	Anchorage Radiation Therapy Center	Anchorage	Alaska	United States	99504
4	Alaska Breast Care and Surgery LLC	Anchorage	Alaska	United States	99508
5	Alaska Oncology and Hematology LLC	Anchorage	Alaska	United States	99508
6	Alaska Women's Cancer Care	Anchorage	Alaska	United States	99508
7	Anchorage Oncology Centre	Anchorage	Alaska	United States	99508
8	Katmai Oncology Group	Anchorage	Alaska	United States	99508
9	Providence Alaska Medical Center	Anchorage	Alaska	United States	99508
10	Fairbanks Memorial Hospital	Fairbanks	Alaska	United States	99701
11	University of Arizona Cancer Center-Orange Grove Campus	Tucson	Arizona	United States	85704
12	University of Arizona Cancer Center-North Campus	Tucson	Arizona	United States	85719
13	The University of Arizona Medical Center-University Campus	Tucson	Arizona	United States	85724
14	Yuma Cancer Center	Yuma	Arizona	United States	85364
15	CHI Saint Vincent Cancer Center Hot Springs	Hot Springs	Arkansas	United States	71913
16	Fowler Family Center for Cancer Care	Jonesboro	Arkansas	United States	72401
17	Kaiser Permanente-Anaheim	Anaheim	California	United States	92806
18	Kaiser Permanente-Deer Valley Medical Center	Antioch	California	United States	94531
19	PCR Oncology	Arroyo Grande	California	United States	93420
20	Sutter Auburn Faith Hospital	Auburn	California	United States	95602
21	Sutter Cancer Centers Radiation Oncology Services-Auburn	Auburn	California	United States	95603
22	AIS Cancer Center at San Joaquin Community Hospital	Bakersfield	California	United States	93301
23	Kaiser Permanente-Baldwin Park	Baldwin Park	California	United States	91706
24	Kaiser Permanente-Bellflower	Bellflower	California	United States	90706
25	Alta Bates Summit Medical Center-Herrick Campus	Berkeley	California	United States	94704
26	Providence Saint Joseph Medical Center/Disney Family Cancer Center	Burbank	California	United States	91505
27	Mills-Peninsula Medical Center	Burlingame	California	United States	94010
28	Sutter Cancer Centers Radiation Oncology Services-Cameron Park	Cameron Park	California	United States	95682
29	Eden Hospital Medical Center	Castro Valley	California	United States	94546
30	City of Hope Corona	Corona	California	United States	92879
31	Sutter Davis Hospital	Davis	California	United States	95616
32	City of Hope Comprehensive Cancer Center	Duarte	California	United States	91010
33	Kaiser Permanente-Fontana	Fontana	California	United States	92335
34	Kaiser Permanente-Fremont	Fremont	California	United States	94538
35	Palo Alto Medical Foundation-Fremont	Fremont	California	United States	94538
36	Kaiser Permanente-Fresno	Fresno	California	United States	93720
37	Saint Jude Medical Center	Fullerton	California	United States	92835
38	Kaiser Permanente - Harbor City	Harbor City	California	United States	90710
39	Kaiser Permanente-Irvine	Irvine	California	United States	92618
40	UC San Diego Moores Cancer Center	La Jolla	California	United States	92093
41	City of Hope Antelope Valley	Lancaster	California	United States	93534
42	Loma Linda University Medical Center	Loma Linda	California	United States	92354
43	Kaiser Permanente Los Angeles Medical Center	Los Angeles	California	United States	90027
44	Kaiser Permanente-Cadillac	Los Angeles	California	United States	90034
45	Fremont - Rideout Cancer Center	Marysville	California	United States	95901
46	City of Hope Mission Hills	Mission Hills	California	United States	91345
47	Memorial Medical Center	Modesto	California	United States	95355
48	Kaiser Permanente-Modesto	Modesto	California	United States	95356
49	Palo Alto Medical Foundation-Camino Division	Mountain View	California	United States	94040
50	Palo Alto Medical Foundation-Gynecologic Oncology	Mountain View	California	United States	94040
51	Sutter Cancer Research Consortium	Novato	California	United States	94945
52	Kaiser Permanente-Oakland	Oakland	California	United States	94611
53	Saint Joseph Hospital - Orange	Orange	California	United States	92868
54	Palo Alto Medical Foundation Health Care	Palo Alto	California	United States	94301
55	Stanford Cancer Institute Palo Alto	Palo Alto	California	United States	94304
56	Kaiser Permanente - Panorama City	Panorama City	California	United States	91402
57	Feather River Cancer Center	Paradise	California	United States	95969
58	City of Hope Rancho Cucamonga	Rancho Cucamonga	California	United States	91730
59	Eisenhower Medical Center	Rancho Mirage	California	United States	92270
60	Kaiser Permanente-Redwood City	Redwood City	California	United States	94063
61	Kaiser Permanente-Richmond	Richmond	California	United States	94801
62	Kaiser Permanente-Riverside	Riverside	California	United States	92505
63	Kaiser Permanente-Roseville	Roseville	California	United States	95661
64	Sutter Cancer Centers Radiation Oncology Services-Roseville	Roseville	California	United States	95661
65	Sutter Roseville Medical Center	Roseville	California	United States	95661
66	Kaiser Permanente Downtown Commons	Sacramento	California	United States	95814
67	Sutter Medical Center Sacramento	Sacramento	California	United States	95816
68	University of California Davis Comprehensive Cancer Center	Sacramento	California	United States	95817
69	Kaiser Permanente-South Sacramento	Sacramento	California	United States	95823
70	Kaiser Permanente - Sacramento	Sacramento	California	United States	95825
71	Saint Helena Hospital	Saint Helena	California	United States	94574
72	Kaiser Permanente-San Diego Mission	San Diego	California	United States	92108
73	Kaiser Permanente-San Diego Zion	San Diego	California	United States	92120
74	California Pacific Medical Center-Pacific Campus	San Francisco	California	United States	94115
75	Kaiser Permanente-San Francisco	San Francisco	California	United States	94115
76	Kaiser Permanente-Santa Teresa-San Jose	San Jose	California	United States	95119
77	Kaiser Permanente San Leandro	San Leandro	California	United States	94577
78	Kaiser Permanente-San Marcos	San Marcos	California	United States	92078
79	Kaiser Permanente-San Rafael	San Rafael	California	United States	94903
80	Kaiser San Rafael-Gallinas	San Rafael	California	United States	94903
81	Kaiser Permanente Medical Center - Santa Clara	Santa Clara	California	United States	95051
82	Palo Alto Medical Foundation-Santa Cruz	Santa Cruz	California	United States	95065
83	Kaiser Permanente-Santa Rosa	Santa Rosa	California	United States	95403
84	Sutter Pacific Medical Foundation	Santa Rosa	California	United States	95403
85	City of Hope South Pasadena	South Pasadena	California	United States	91030
86	Kaiser Permanente-South San Francisco	South San Francisco	California	United States	94080
87	Kaiser Permanente-Stockton	Stockton	California	United States	95210
88	Palo Alto Medical Foundation-Sunnyvale	Sunnyvale	California	United States	94086
89	Gene Upshaw Memorial Tahoe Forest Cancer Center	Truckee	California	United States	96161
90	Northbay Cancer Center	Vacaville	California	United States	95687
91	Sutter Cancer Centers Radiation Oncology Services-Vacaville	Vacaville	California	United States	95687
92	Kaiser Permanente Medical Center-Vacaville	Vacaville	California	United States	95688
93	Kaiser Permanente-Vallejo	Vallejo	California	United States	94589
94	Sutter Solano Medical Center/Cancer Center	Vallejo	California	United States	94589
95	Kaiser Permanente-Walnut Creek	Walnut Creek	California	United States	94596
96	Presbyterian Intercommunity Hospital	Whittier	California	United States	90602
97	Kaiser Permanente-Woodland Hills	Woodland Hills	California	United States	91367
98	Rocky Mountain Cancer Centers-Aurora	Aurora	Colorado	United States	80012
99	University of Colorado Hospital	Aurora	Colorado	United States	80045
100	Boulder Community Hospital	Boulder	Colorado	United States	80301
101	Rocky Mountain Cancer Centers-Boulder	Boulder	Colorado	United States	80304
102	Penrose-Saint Francis Healthcare	Colorado Springs	Colorado	United States	80907
103	Rocky Mountain Cancer Centers-Penrose	Colorado Springs	Colorado	United States	80907
104	UCHealth Memorial Hospital Central	Colorado Springs	Colorado	United States	80909
105	Denver Health Medical Center	Denver	Colorado	United States	80204
106	Kaiser Permanente-Franklin	Denver	Colorado	United States	80205
107	National Jewish Health-Main Campus	Denver	Colorado	United States	80206
108	The Women's Imaging Center	Denver	Colorado	United States	80209
109	Porter Adventist Hospital	Denver	Colorado	United States	80210
110	Colorado Blood Cancer Institute	Denver	Colorado	United States	80218
111	Presbyterian - Saint Lukes Medical Center - Health One	Denver	Colorado	United States	80218
112	Rocky Mountain Cancer Centers-Midtown	Denver	Colorado	United States	80218
113	SCL Health Saint Joseph Hospital	Denver	Colorado	United States	80218
114	Rocky Mountain Cancer Centers-Rose	Denver	Colorado	United States	80220
115	Rose Medical Center	Denver	Colorado	United States	80220
116	Mercy Medical Center	Durango	Colorado	United States	81301
117	Southwest Oncology PC	Durango	Colorado	United States	81301
118	Comprehensive Cancer Care and Research Institute of Colorado LLC	Englewood	Colorado	United States	80113
119	Swedish Medical Center	Englewood	Colorado	United States	80113
120	Poudre Valley Hospital	Fort Collins	Colorado	United States	80524
121	Mountain Blue Cancer Care Center	Golden	Colorado	United States	80401
122	National Jewish Health-Western Hematology Oncology	Golden	Colorado	United States	80401
123	Saint Mary's Hospital and Regional Medical Center	Grand Junction	Colorado	United States	81501
124	North Colorado Medical Center	Greeley	Colorado	United States	80631
125	Rocky Mountain Cancer Centers-Greenwood Village	Greenwood Village	Colorado	United States	80111
126	Good Samaritan Medical Center	Lafayette	Colorado	United States	80026
127	Kaiser Permanente-Rock Creek	Lafayette	Colorado	United States	80026
128	Rocky Mountain Cancer Centers-Lakewood	Lakewood	Colorado	United States	80228
129	Saint Anthony Hospital	Lakewood	Colorado	United States	80228
130	Rocky Mountain Cancer Centers-Littleton	Littleton	Colorado	United States	80120
131	Littleton Adventist Hospital	Littleton	Colorado	United States	80122
132	Kaiser Permanente-Lone Tree	Lone Tree	Colorado	United States	80124
133	Rocky Mountain Cancer Centers-Sky Ridge	Lone Tree	Colorado	United States	80124
134	Longmont United Hospital	Longmont	Colorado	United States	80501
135	Rocky Mountain Cancer Centers-Longmont	Longmont	Colorado	United States	80501
136	McKee Medical Center	Loveland	Colorado	United States	80539
137	Parker Adventist Hospital	Parker	Colorado	United States	80138
138	Rocky Mountain Cancer Centers-Parker	Parker	Colorado	United States	80138
139	Saint Mary Corwin Medical Center	Pueblo	Colorado	United States	81004
140	Rocky Mountain Cancer Centers - Pueblo	Pueblo	Colorado	United States	81008
141	National Jewish Health-Northern Hematology Oncology	Thornton	Colorado	United States	80260
142	Rocky Mountain Cancer Centers-Thornton	Thornton	Colorado	United States	80260
143	SCL Health Lutheran Medical Center	Wheat Ridge	Colorado	United States	80033
144	Smilow Cancer Hospital-Derby Care Center	Derby	Connecticut	United States	06418
145	Smilow Cancer Hospital Care Center-Fairfield	Fairfield	Connecticut	United States	06824
146	Yale-New Haven Shoreline Medical Center	Guilford	Connecticut	United States	06437
147	Hartford Hospital	Hartford	Connecticut	United States	06102
148	Smilow Cancer Hospital Care Center at Saint Francis	Hartford	Connecticut	United States	06105
149	Midstate Medical Center	Meriden	Connecticut	United States	06451
150	The Hospital of Central Connecticut	New Britain	Connecticut	United States	06050
151	Smilow Cancer Center/Yale-New Haven Hospital	New Haven	Connecticut	United States	06510
152	Yale University	New Haven	Connecticut	United States	06520
153	Yale-New Haven Hospital North Haven Medical Center	North Haven	Connecticut	United States	06473
154	Eastern Connecticut Hematology and Oncology Associates	Norwich	Connecticut	United States	06360
155	Smilow Cancer Hospital-Orange Care Center	Orange	Connecticut	United States	06477
156	Smilow Cancer Hospital-Torrington Care Center	Torrington	Connecticut	United States	06790
157	Smilow Cancer Hospital Care Center-Trumbull	Trumbull	Connecticut	United States	06611
158	Smilow Cancer Hospital-Waterbury Care Center	Waterbury	Connecticut	United States	06708
159	Lawrence and Memorial Cancer Center	Waterford	Connecticut	United States	06385
160	Veterans Affairs Connecticut Healthcare System-West Haven Campus	West Haven	Connecticut	United States	06516
161	Beebe Medical Center	Lewes	Delaware	United States	19958
162	Delaware Clinical and Laboratory Physicians PA	Newark	Delaware	United States	19713
163	Helen F Graham Cancer Center	Newark	Delaware	United States	19713
164	Medical Oncology Hematology Consultants PA	Newark	Delaware	United States	19713
165	Regional Hematology and Oncology PA	Newark	Delaware	United States	19713
166	Christiana Care Health System-Christiana Hospital	Newark	Delaware	United States	19718
167	Beebe Health Campus	Rehoboth Beach	Delaware	United States	19971
168	Nanticoke Memorial Hospital	Seaford	Delaware	United States	19973
169	Christiana Care Health System-Wilmington Hospital	Wilmington	Delaware	United States	19801
170	Kaiser Permanente-Capitol Hill Medical Center	Washington	District of Columbia	United States	20002
171	MedStar Georgetown University Hospital	Washington	District of Columbia	United States	20007
172	Sibley Memorial Hospital	Washington	District of Columbia	United States	20016
173	Mount Sinai Comprehensive Cancer Center at Aventura	Aventura	Florida	United States	33180
174	UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	United States	33146
175	Halifax Health Medical Center-Centers for Oncology	Daytona Beach	Florida	United States	32114
176	UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	United States	33442
177	Holy Cross Hospital	Fort Lauderdale	Florida	United States	33308
178	University of Florida Health Science Center - Gainesville	Gainesville	Florida	United States	32610
179	Memorial Regional Hospital/Joe DiMaggio Children's Hospital	Hollywood	Florida	United States	33021
180	UM Sylvester Comprehensive Cancer Center at Hollywood	Hollywood	Florida	United States	33021
181	Mount Sinai Medical Center	Miami Beach	Florida	United States	33140
182	University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	United States	33136
183	Memorial Hospital West	Pembroke Pines	Florida	United States	33028
184	Sacred Heart Hospital	Pensacola	Florida	United States	32504
185	UM Sylvester Comprehensive Cancer Center at Plantation	Plantation	Florida	United States	33324
186	Moffitt Cancer Center	Tampa	Florida	United States	33612
187	Phoebe Putney Memorial Hospital	Albany	Georgia	United States	31701
188	University Cancer and Blood Center LLC	Athens	Georgia	United States	30607
189	Emory University Hospital Midtown	Atlanta	Georgia	United States	30308
190	Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	United States	30322
191	Emory Saint Joseph's Hospital	Atlanta	Georgia	United States	30342
192	Northside Hospital	Atlanta	Georgia	United States	30342
193	Augusta University Medical Center	Augusta	Georgia	United States	30912
194	John B Amos Cancer Center	Columbus	Georgia	United States	31904
195	Northside Hospital-Forsyth	Cumming	Georgia	United States	30041
196	Dekalb Medical Center	Decatur	Georgia	United States	30033
197	Northeast Georgia Medical Center-Gainesville	Gainesville	Georgia	United States	30501
198	Gwinnett Medical Center	Lawrenceville	Georgia	United States	30046
199	Central Georgia Gynecologic Oncology	Macon	Georgia	United States	31201
200	Medical Center of Central Georgia	Macon	Georgia	United States	31201
201	Harbin Clinic Medical Oncology and Clinical Research	Rome	Georgia	United States	30165
202	Memorial Health University Medical Center	Savannah	Georgia	United States	31404
203	Summit Cancer Care-Memorial	Savannah	Georgia	United States	31404
204	Lewis Cancer and Research Pavilion at Saint Joseph's/Candler	Savannah	Georgia	United States	31405
205	Low Country Cancer Care Associates PC	Savannah	Georgia	United States	31405
206	Summit Cancer Care-Candler	Savannah	Georgia	United States	31405
207	South Georgia Medical Center/Pearlman Cancer Center	Valdosta	Georgia	United States	31602
208	Hawaii Oncology Inc-Pali Momi	'Aiea	Hawaii	United States	96701
209	Pali Momi Medical Center	'Aiea	Hawaii	United States	96701
210	The Cancer Center of Hawaii-Pali Momi	'Aiea	Hawaii	United States	96701
211	Hawaii Cancer Care Inc-POB II	Honolulu	Hawaii	United States	96813
212	Hawaii Oncology Inc-POB I	Honolulu	Hawaii	United States	96813
213	Island Urology	Honolulu	Hawaii	United States	96813
214	Queen's Medical Center	Honolulu	Hawaii	United States	96813
215	Straub Clinic and Hospital	Honolulu	Hawaii	United States	96813
216	University of Hawaii Cancer Center	Honolulu	Hawaii	United States	96813
217	Hawaii Cancer Care Inc-Liliha	Honolulu	Hawaii	United States	96817
218	Hawaii Oncology Inc-Kuakini	Honolulu	Hawaii	United States	96817
219	Kuakini Medical Center	Honolulu	Hawaii	United States	96817
220	The Cancer Center of Hawaii-Liliha	Honolulu	Hawaii	United States	96817
221	Kaiser Permanente Moanalua Medical Center	Honolulu	Hawaii	United States	96819
222	Kapiolani Medical Center for Women and Children	Honolulu	Hawaii	United States	96826
223	Wilcox Memorial Hospital and Kauai Medical Clinic	Lihue	Hawaii	United States	96766
224	Saint Alphonsus Cancer Care Center-Boise	Boise	Idaho	United States	83706
225	Saint Luke's Mountain States Tumor Institute	Boise	Idaho	United States	83712
226	Saint Alphonsus Cancer Care Center-Caldwell	Caldwell	Idaho	United States	83605
227	Kootenai Medical Center	Coeur d'Alene	Idaho	United States	83814
228	Walter Knox Memorial Hospital	Emmett	Idaho	United States	83617
229	Saint Luke's Mountain States Tumor Institute - Fruitland	Fruitland	Idaho	United States	83619
230	Idaho Urologic Institute-Meridian	Meridian	Idaho	United States	83642
231	Saint Luke's Mountain States Tumor Institute - Meridian	Meridian	Idaho	United States	83642
232	Saint Alphonsus Medical Center-Nampa	Nampa	Idaho	United States	83686
233	Saint Luke's Mountain States Tumor Institute - Nampa	Nampa	Idaho	United States	83686
234	Kootenai Cancer Center	Post Falls	Idaho	United States	83854
235	Kootenai Cancer Clinic	Sandpoint	Idaho	United States	83864
236	Saint Luke's Mountain States Tumor Institute-Twin Falls	Twin Falls	Idaho	United States	83301
237	Rush - Copley Medical Center	Aurora	Illinois	United States	60504
238	Saint Joseph Medical Center	Bloomington	Illinois	United States	61701
239	Illinois CancerCare-Bloomington	Bloomington	Illinois	United States	61704
240	Illinois CancerCare-Canton	Canton	Illinois	United States	61520
241	Memorial Hospital of Carbondale	Carbondale	Illinois	United States	62902
242	SIH Cancer Institute	Carterville	Illinois	United States	62918
243	Illinois CancerCare-Carthage	Carthage	Illinois	United States	62321
244	Centralia Oncology Clinic	Centralia	Illinois	United States	62801
245	Mount Sinai Hospital Medical Center	Chicago	Illinois	United States	60608
246	Northwestern University	Chicago	Illinois	United States	60611
247	John H Stroger Jr Hospital of Cook County	Chicago	Illinois	United States	60612
248	Rush University Medical Center	Chicago	Illinois	United States	60612
249	Swedish Covenant Hospital	Chicago	Illinois	United States	60625
250	University of Chicago Comprehensive Cancer Center	Chicago	Illinois	United States	60637
251	Carle on Vermilion	Danville	Illinois	United States	61832
252	Cancer Care Specialists of Illinois - Decatur	Decatur	Illinois	United States	62526
253	Decatur Memorial Hospital	Decatur	Illinois	United States	62526
254	Carle Physician Group-Effingham	Effingham	Illinois	United States	62401
255	Crossroads Cancer Center	Effingham	Illinois	United States	62401
256	AMITA Health Alexian Brothers Medical Center	Elk Grove Village	Illinois	United States	60007
257	Illinois CancerCare-Eureka	Eureka	Illinois	United States	61530
258	NorthShore University HealthSystem-Evanston Hospital	Evanston	Illinois	United States	60201
259	Saint Francis Hospital	Evanston	Illinois	United States	60202
260	Illinois CancerCare-Galesburg	Galesburg	Illinois	United States	61401
261	Western Illinois Cancer Treatment Center	Galesburg	Illinois	United States	61401
262	Northwestern Medicine Cancer Center Delnor	Geneva	Illinois	United States	60134
263	NorthShore University HealthSystem-Glenbrook Hospital	Glenview	Illinois	United States	60026
264	Ingalls Memorial Hospital	Harvey	Illinois	United States	60426
265	NorthShore University HealthSystem-Highland Park Hospital	Highland Park	Illinois	United States	60035
266	Hines Veterans Administration Hospital	Hines	Illinois	United States	60141
267	AMITA Health Cancer Institute and Outpatient Center	Hinsdale	Illinois	United States	60521
268	Joliet Oncology-Hematology Associates Limited	Joliet	Illinois	United States	60435
269	Presence Saint Mary's Hospital	Kankakee	Illinois	United States	60901
270	Illinois CancerCare-Kewanee Clinic	Kewanee	Illinois	United States	61443
271	Illinois CancerCare-Macomb	Macomb	Illinois	United States	61455
272	Carle Physician Group-Mattoon/Charleston	Mattoon	Illinois	United States	61938
273	Loyola University Medical Center	Maywood	Illinois	United States	60153
274	Trinity Medical Center	Moline	Illinois	United States	61265
275	Good Samaritan Regional Health Center	Mount Vernon	Illinois	United States	62864
276	AMG Oncology - Naperville	Naperville	Illinois	United States	60540
277	UC Comprehensive Cancer Center at Silver Cross	New Lenox	Illinois	United States	60451
278	University of Chicago Medicine-Orland Park	Orland Park	Illinois	United States	60462
279	Illinois CancerCare-Ottawa Clinic	Ottawa	Illinois	United States	61350
280	Illinois CancerCare-Pekin	Pekin	Illinois	United States	61554
281	OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center	Pekin	Illinois	United States	61554
282	Illinois CancerCare-Peoria	Peoria	Illinois	United States	61615
283	OSF Saint Francis Radiation Oncology at Peoria Cancer Center	Peoria	Illinois	United States	61615
284	Methodist Medical Center of Illinois	Peoria	Illinois	United States	61636
285	OSF Saint Francis Medical Center	Peoria	Illinois	United States	61637
286	Illinois CancerCare-Peru	Peru	Illinois	United States	61354
287	Valley Radiation Oncology	Peru	Illinois	United States	61354
288	Illinois CancerCare-Princeton	Princeton	Illinois	United States	61356
289	North Shore Medical Center	Skokie	Illinois	United States	60076
290	Central Illinois Hematology Oncology Center	Springfield	Illinois	United States	62702
291	Southern Illinois University School of Medicine	Springfield	Illinois	United States	62702
292	Springfield Clinic	Springfield	Illinois	United States	62702
293	Memorial Medical Center	Springfield	Illinois	United States	62781
294	Cancer Care Specialists of Illinois-Swansea	Swansea	Illinois	United States	62226
295	Southwest Illinois Health Services LLP	Swansea	Illinois	United States	62226
296	Carle Cancer Center	Urbana	Illinois	United States	61801
297	The Carle Foundation Hospital	Urbana	Illinois	United States	61801
298	Northwestern Medicine Cancer Center Warrenville	Warrenville	Illinois	United States	60555
299	Rush-Copley Healthcare Center	Yorkville	Illinois	United States	60560
300	IU Health North Hospital	Carmel	Indiana	United States	46032
301	Deaconess Clinic Downtown	Evansville	Indiana	United States	47713
302	IU Health Central Indiana Cancer Centers-Fishers	Fishers	Indiana	United States	46037
303	Parkview Hospital Randallia	Fort Wayne	Indiana	United States	46805
304	Indiana University/Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	United States	46202
305	IU Health Methodist Hospital	Indianapolis	Indiana	United States	46202
306	Richard L. Roudebush Veterans Affairs Medical Center	Indianapolis	Indiana	United States	46202
307	Sidney and Lois Eskenazi Hospital	Indianapolis	Indiana	United States	46202
308	IU Health Central Indiana Cancer Centers-East	Indianapolis	Indiana	United States	46219
309	Franciscan Health Indianapolis	Indianapolis	Indiana	United States	46237
310	Springmill Medical Center	Indianapolis	Indiana	United States	46290
311	Franciscan Saint Anthony Health-Michigan City	Michigan City	Indiana	United States	46360
312	Woodland Cancer Care Center	Michigan City	Indiana	United States	46360
313	Memorial Regional Cancer Center Day Road	Mishawaka	Indiana	United States	46545
314	Franciscan Health Mooresville	Mooresville	Indiana	United States	46158
315	The Community Hospital	Munster	Indiana	United States	46321
316	Chancellor Center for Oncology	Newburgh	Indiana	United States	47630
317	Reid Health	Richmond	Indiana	United States	47374
318	Memorial Hospital of South Bend	South Bend	Indiana	United States	46601
319	Union Hospital	Terre Haute	Indiana	United States	47804
320	Mary Greeley Medical Center	Ames	Iowa	United States	50010
321	McFarland Clinic PC - Ames	Ames	Iowa	United States	50010
322	University of Iowa Healthcare Cancer Services Quad Cities	Bettendorf	Iowa	United States	52722
323	McFarland Clinic PC-Boone	Boone	Iowa	United States	50036
324	Medical Oncology and Hematology Associates-West Des Moines	Clive	Iowa	United States	50325
325	Mercy Cancer Center-West Lakes	Clive	Iowa	United States	50325
326	Alegent Health Mercy Hospital	Council Bluffs	Iowa	United States	51503
327	Greater Regional Medical Center	Creston	Iowa	United States	50801
328	Genesis Medical Center - East Campus	Davenport	Iowa	United States	52803
329	Iowa Methodist Medical Center	Des Moines	Iowa	United States	50309
330	Medical Oncology and Hematology Associates-Des Moines	Des Moines	Iowa	United States	50309
331	Broadlawns Medical Center	Des Moines	Iowa	United States	50314
332	Medical Oncology and Hematology Associates-Laurel	Des Moines	Iowa	United States	50314
333	Mercy Medical Center - Des Moines	Des Moines	Iowa	United States	50314
334	Iowa Lutheran Hospital	Des Moines	Iowa	United States	50316
335	JCHC McCreery Cancer Center	Fairfield	Iowa	United States	52556
336	McFarland Clinic PC-Trinity Cancer Center	Fort Dodge	Iowa	United States	50501
337	University of Iowa/Holden Comprehensive Cancer Center	Iowa City	Iowa	United States	52242
338	McFarland Clinic PC-Jefferson	Jefferson	Iowa	United States	50129
339	McFarland Clinic PC-Marshalltown	Marshalltown	Iowa	United States	50158
340	Ottumwa Regional Health Center	Ottumwa	Iowa	United States	52501
341	Siouxland Regional Cancer Center	Sioux City	Iowa	United States	51101
342	Covenant Medical Center	Waterloo	Iowa	United States	50702
343	Methodist West Hospital	West Des Moines	Iowa	United States	50266-7700
344	Mercy Medical Center-West Lakes	West Des Moines	Iowa	United States	50266
345	Cancer Center of Kansas - Chanute	Chanute	Kansas	United States	66720
346	Coffeyville Regional Medical Center	Coffeyville	Kansas	United States	67337
347	Cancer Center of Kansas - Dodge City	Dodge City	Kansas	United States	67801
348	Cancer Center of Kansas - El Dorado	El Dorado	Kansas	United States	67042
349	Newman Regional Health	Emporia	Kansas	United States	66801
350	Cancer Center of Kansas - Fort Scott	Fort Scott	Kansas	United States	66701
351	Central Care Cancer Center - Garden City	Garden City	Kansas	United States	67846
352	Saint Catherine Hospital	Garden City	Kansas	United States	67846
353	Central Care Cancer Center - Great Bend	Great Bend	Kansas	United States	67530
354	Saint Rose Ambulatory and Surgery Center	Great Bend	Kansas	United States	67530
355	Hays Medical Center	Hays	Kansas	United States	67601
356	Cancer Center of Kansas-Independence	Independence	Kansas	United States	67301
357	University of Kansas Cancer Center-West	Kansas City	Kansas	United States	66112
358	University of Kansas Cancer Center	Kansas City	Kansas	United States	66160
359	Cancer Center of Kansas-Kingman	Kingman	Kansas	United States	67068
360	Lawrence Memorial Hospital	Lawrence	Kansas	United States	66044
361	Kansas Institute of Medicine Cancer and Blood Center	Lenexa	Kansas	United States	66219
362	Minimally Invasive Surgery Hospital	Lenexa	Kansas	United States	66219
363	Cancer Center of Kansas-Liberal	Liberal	Kansas	United States	67905
364	Cancer Center of Kansas-Manhattan	Manhattan	Kansas	United States	66502
365	Cancer Center of Kansas - McPherson	McPherson	Kansas	United States	67460
366	Cancer Center of Kansas - Newton	Newton	Kansas	United States	67114
367	Olathe Medical Center	Olathe	Kansas	United States	66061
368	Menorah Medical Center	Overland Park	Kansas	United States	66209
369	University of Kansas Cancer Center-Overland Park	Overland Park	Kansas	United States	66210
370	Saint Luke's South Hospital	Overland Park	Kansas	United States	66213
371	Cancer Center of Kansas - Parsons	Parsons	Kansas	United States	67357
372	Via Christi Hospital-Pittsburg	Pittsburg	Kansas	United States	66762
373	Cancer Center of Kansas - Pratt	Pratt	Kansas	United States	67124
374	Cancer Center of Kansas - Salina	Salina	Kansas	United States	67401
375	Salina Regional Health Center	Salina	Kansas	United States	67401
376	Cotton O'Neil Cancer Center / Stormont Vail Health	Topeka	Kansas	United States	66606
377	Saint Francis Hospital and Medical Center - Topeka	Topeka	Kansas	United States	66606
378	Cancer Center of Kansas - Wellington	Wellington	Kansas	United States	67152
379	University of Kansas Hospital-Westwood Cancer Center	Westwood	Kansas	United States	66205
380	Associates In Womens Health	Wichita	Kansas	United States	67208
381	Cancer Center of Kansas-Wichita Medical Arts Tower	Wichita	Kansas	United States	67208
382	Cancer Center of Kansas - Wichita	Wichita	Kansas	United States	67214
383	Via Christi Regional Medical Center	Wichita	Kansas	United States	67214
384	Cancer Center of Kansas - Winfield	Winfield	Kansas	United States	67156
385	King's Daughter's Medical Center	Ashland	Kentucky	United States	41101
386	Flaget Memorial Hospital	Bardstown	Kentucky	United States	40004
387	Baptist Health Corbin	Corbin	Kentucky	United States	40701
388	Commonwealth Cancer Center-Corbin	Corbin	Kentucky	United States	40701
389	Oncology Hematology Care Inc-Crestview	Crestview Hills	Kentucky	United States	41017
390	Hardin Memorial Hospital	Elizabethtown	Kentucky	United States	42701
391	Baptist Health Lexington	Lexington	Kentucky	United States	40503
392	Saint Joseph Radiation Oncology Resource Center	Lexington	Kentucky	United States	40504
393	Saint Joseph Hospital East	Lexington	Kentucky	United States	40509
394	University of Kentucky/Markey Cancer Center	Lexington	Kentucky	United States	40536
395	Saint Joseph London	London	Kentucky	United States	40741
396	Jewish Hospital	Louisville	Kentucky	United States	40202
397	Norton Hospital Pavilion and Medical Campus	Louisville	Kentucky	United States	40202
398	Baptist Health Louisville	Louisville	Kentucky	United States	40207
399	Norton Suburban Hospital and Medical Campus	Louisville	Kentucky	United States	40207
400	Saints Mary and Elizabeth Hospital	Louisville	Kentucky	United States	40215
401	Norton Audubon Hospital and Medical Campus	Louisville	Kentucky	United States	40217
402	Norton Brownsboro Hospital and Medical Campus	Louisville	Kentucky	United States	40241
403	Jewish Hospital Medical Center Northeast	Louisville	Kentucky	United States	40245
404	Baptist Health Madisonville/Merle Mahr Cancer Center	Madisonville	Kentucky	United States	42431
405	Baptist Health Paducah	Paducah	Kentucky	United States	42003
406	Jewish Hospital Medical Center South	Shepherdsville	Kentucky	United States	40165
407	LSU Health Baton Rouge-North Clinic	Baton Rouge	Louisiana	United States	70805
408	Baton Rouge General Medical Center	Baton Rouge	Louisiana	United States	70806
409	Hematology/Oncology Clinic LLP	Baton Rouge	Louisiana	United States	70809
410	Louisiana Hematology Oncology Associates LLC	Baton Rouge	Louisiana	United States	70809
411	Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	United States	70809
412	Ochsner Health Center-Summa	Baton Rouge	Louisiana	United States	70809
413	Our Lady of the Lake Physicians Group - Medical Oncology	Baton Rouge	Louisiana	United States	70809
414	Medical Center of Baton Rouge	Baton Rouge	Louisiana	United States	70816
415	Mary Bird Cancer Center/Saint Tammany Parish	Covington	Louisiana	United States	70433
416	Northshore Oncology Associates-Covington	Covington	Louisiana	United States	70433
417	Mary Bird Perkins Cancer Center/Terrebonne General Medical Center	Houma	Louisiana	United States	70360
418	Oncology Center of The South Incorporated	Houma	Louisiana	United States	70360
419	Ochsner Medical Center Kenner	Kenner	Louisiana	United States	70065
420	East Jefferson General Hospital	Metairie	Louisiana	United States	70006
421	Robert Veith MD LLC	Metairie	Louisiana	United States	70006
422	Louisiana State University Health Science Center	New Orleans	Louisiana	United States	70112
423	Tulane University Health Sciences Center	New Orleans	Louisiana	United States	70112
424	University Medical Center New Orleans	New Orleans	Louisiana	United States	70112
425	LSU Healthcare Network/Saint Charles	New Orleans	Louisiana	United States	70115
426	Ochsner Medical Center Jefferson	New Orleans	Louisiana	United States	70121
427	Harold Alfond Center for Cancer Care	Augusta	Maine	United States	04330
428	Eastern Maine Medical Center	Bangor	Maine	United States	04401
429	Waldo County General Hospital	Belfast	Maine	United States	04915
430	MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford	Biddeford	Maine	United States	04005
431	Lafayette Family Cancer Center-EMMC	Brewer	Maine	United States	04412
432	Mercy Hospital	Portland	Maine	United States	04101
433	Penobscot Bay Medical Center	Rockport	Maine	United States	04856
434	MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford	Sanford	Maine	United States	04073
435	University of Maryland/Greenebaum Cancer Center	Baltimore	Maryland	United States	21201
436	Greater Baltimore Medical Center	Baltimore	Maryland	United States	21204
437	Sinai Hospital of Baltimore	Baltimore	Maryland	United States	21215
438	MedStar Union Memorial Hospital	Baltimore	Maryland	United States	21218
439	Saint Agnes Hospital	Baltimore	Maryland	United States	21229
440	MedStar Franklin Square Medical Center/Weinberg Cancer Institute	Baltimore	Maryland	United States	21237
441	Kaiser Permanente-Woodlawn Medical Center	Baltimore	Maryland	United States	21244
442	Johns Hopkins University/Sidney Kimmel Cancer Center	Baltimore	Maryland	United States	21287
443	Upper Chesapeake Medical Center	Bel Air	Maryland	United States	21014
444	Western Maryland Regional Medical Center	Cumberland	Maryland	United States	21502
445	Frederick Memorial Hospital	Frederick	Maryland	United States	21701
446	Kaiser Permanente-Gaithersburg Medical Center	Gaithersburg	Maryland	United States	20879
447	Kaiser Permanente - Kensington Medical Center	Kensington	Maryland	United States	20895
448	Kaiser Permanente - Largo Medical Center	Largo	Maryland	United States	20774
449	MedStar Montgomery Medical Center	Olney	Maryland	United States	20832
450	Northwest Hospital Center	Randallstown	Maryland	United States	21133
451	Peninsula Regional Medical Center	Salisbury	Maryland	United States	21801
452	William E Kahlert Regional Cancer Center/Sinai Hospital	Westminster	Maryland	United States	21157
453	Beverly Hospital	Beverly	Massachusetts	United States	01915
454	Massachusetts General Hospital Cancer Center	Boston	Massachusetts	United States	02114
455	Boston Medical Center	Boston	Massachusetts	United States	02118
456	Beth Israel Deaconess Medical Center	Boston	Massachusetts	United States	02215
457	Lahey Hospital and Medical Center	Burlington	Massachusetts	United States	01805
458	Simonds-Sinon Regional Cancer Center	Fitchburg	Massachusetts	United States	01420
459	Addison Gilbert Hospital	Gloucester	Massachusetts	United States	01930
460	Lowell General Hospital	Lowell	Massachusetts	United States	01854
461	Dana-Farber/Brigham and Women's Cancer Center at Milford Regional	Milford	Massachusetts	United States	01757
462	Dana-Farber/Brigham and Women's Cancer Center at South Shore	South Weymouth	Massachusetts	United States	02190
463	Baystate Medical Center	Springfield	Massachusetts	United States	01199
464	Winchester Hospital	Winchester	Massachusetts	United States	01890
465	University of Massachusetts Medical School	Worcester	Massachusetts	United States	01655
466	Saint Joseph Mercy Hospital	Ann Arbor	Michigan	United States	48106
467	University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	United States	48109
468	Bronson Battle Creek	Battle Creek	Michigan	United States	49017
469	IHA Hematology Oncology Consultants-Brighton	Brighton	Michigan	United States	48114
470	Saint Joseph Mercy Brighton	Brighton	Michigan	United States	48114
471	Henry Ford Cancer Institute?Downriver	Brownstown	Michigan	United States	48183
472	IHA Hematology Oncology Consultants-Canton	Canton	Michigan	United States	48188
473	Saint Joseph Mercy Canton	Canton	Michigan	United States	48188
474	Caro Cancer Center	Caro	Michigan	United States	48723
475	IHA Hematology Oncology Consultants-Chelsea	Chelsea	Michigan	United States	48118
476	Saint Joseph Mercy Chelsea	Chelsea	Michigan	United States	48118
477	Hematology Oncology Consultants-Clarkston	Clarkston	Michigan	United States	48346
478	Newland Medical Associates-Clarkston	Clarkston	Michigan	United States	48346
479	Henry Ford Macomb Hospital-Clinton Township	Clinton Township	Michigan	United States	48038
480	Beaumont Hospital-Dearborn	Dearborn	Michigan	United States	48124
481	Henry Ford Medical Center-Fairlane	Dearborn	Michigan	United States	48126
482	Wayne State University/Karmanos Cancer Institute	Detroit	Michigan	United States	48201
483	Henry Ford Hospital	Detroit	Michigan	United States	48202
484	Saint John Hospital and Medical Center	Detroit	Michigan	United States	48236
485	Great Lakes Cancer Management Specialists-Doctors Park	East China Township	Michigan	United States	48054
486	Green Bay Oncology - Escanaba	Escanaba	Michigan	United States	49829
487	Weisberg Cancer Treatment Center	Farmington Hills	Michigan	United States	48334
488	Beaumont Hospital - Farmington Hills	Farmington Hills	Michigan	United States	48336
489	Genesee Cancer and Blood Disease Treatment Center	Flint	Michigan	United States	48503
490	Genesee Hematology Oncology PC	Flint	Michigan	United States	48503
491	Genesys Hurley Cancer Institute	Flint	Michigan	United States	48503
492	Hurley Medical Center	Flint	Michigan	United States	48503
493	Mercy Health Saint Mary's	Grand Rapids	Michigan	United States	49503
494	Spectrum Health at Butterworth Campus	Grand Rapids	Michigan	United States	49503
495	Great Lakes Cancer Management Specialists-Van Elslander Cancer Center	Grosse Pointe Woods	Michigan	United States	48236
496	Lymphoma Clinic of Michigan	Grosse Pointe Woods	Michigan	United States	48236
497	Michigan Breast Specialists-Grosse Pointe Woods	Grosse Pointe Woods	Michigan	United States	48236
498	William Beaumont Hospital-Grosse Point	Grosse Pointe	Michigan	United States	48230
499	Allegiance Health	Jackson	Michigan	United States	49201
500	West Michigan Cancer Center	Kalamazoo	Michigan	United States	49007
501	Borgess Medical Center	Kalamazoo	Michigan	United States	49048
502	Sparrow Hospital	Lansing	Michigan	United States	48912
503	Hope Cancer Clinic	Livonia	Michigan	United States	48154
504	Saint Mary Mercy Hospital	Livonia	Michigan	United States	48154
505	Great Lakes Cancer Management Specialists-Macomb Medical Campus	Macomb	Michigan	United States	48044
506	Michigan Breast Specialists-Macomb Township	Macomb	Michigan	United States	48044
507	Saint Mary's Oncology/Hematology Associates of Marlette	Marlette	Michigan	United States	48453
508	Mid-Michigan Medical Center - Midland	Midland	Michigan	United States	48670
509	Monroe Cancer Center	Monroe	Michigan	United States	48162
510	Mercy Health Mercy Campus	Muskegon	Michigan	United States	49444
511	Lakeland Hospital Niles	Niles	Michigan	United States	49120
512	Assarian Cancer Center	Novi	Michigan	United States	48374-1236
513	Henry Ford Medical Center-Columbus	Novi	Michigan	United States	48377
514	21st Century Oncology-Pontiac	Pontiac	Michigan	United States	48341
515	Hope Cancer Center	Pontiac	Michigan	United States	48341
516	Newland Medical Associates-Pontiac	Pontiac	Michigan	United States	48341
517	Saint Joseph Mercy Oakland	Pontiac	Michigan	United States	48341
518	Huron Medical Center PC	Port Huron	Michigan	United States	48060
519	Lake Huron Medical Center	Port Huron	Michigan	United States	48060
520	Spectrum Health Reed City Hospital	Reed City	Michigan	United States	49677
521	Great Lakes Cancer Management Specialists-Rochester Hills	Rochester Hills	Michigan	United States	48309
522	Michigan Cancer Specialists	Roseville	Michigan	United States	48066
523	Oakland Colon and Rectal Association	Royal Oak	Michigan	United States	48067
524	Cancer Care Associates PC	Royal Oak	Michigan	United States	48073
525	Comprehensive Medical Center PLLC	Royal Oak	Michigan	United States	48073
526	Hematology Oncology Consultants PC	Royal Oak	Michigan	United States	48073
527	Oakland Medical Group	Royal Oak	Michigan	United States	48073
528	William Beaumont Hospital-Royal Oak	Royal Oak	Michigan	United States	48073
529	Saint Mary's of Michigan	Saginaw	Michigan	United States	48601
530	Oncology Hematology Associates of Saginaw Valley PC	Saginaw	Michigan	United States	48604
531	Lakeland Medical Center Saint Joseph	Saint Joseph	Michigan	United States	49085
532	Marie Yeager Cancer Center	Saint Joseph	Michigan	United States	49085
533	Providence Hospital-Southfield Cancer Center	Southfield	Michigan	United States	48075
534	Bhadresh Nayak MD PC-Sterling Heights	Sterling Heights	Michigan	United States	48312
535	Premier Hematology Oncology Care	Sterling Heights	Michigan	United States	48312
536	Mitchell Folbe MD PC	Sterling Heights	Michigan	United States	48314
537	Saint Joseph Health System-Tawas City	Tawas City	Michigan	United States	48764
538	Munson Medical Center	Traverse City	Michigan	United States	49684
539	Michigan Institute of Urology-Town Center	Troy	Michigan	United States	48084
540	Claudia BR Herke MD PC	Troy	Michigan	United States	48085
541	Hematology Oncology Consultants PC-Troy	Troy	Michigan	United States	48098
542	William Beaumont Hospital - Troy	Troy	Michigan	United States	48098
543	Advanced Breast Care Center PLLC	Warren	Michigan	United States	48088
544	Bhadresh Nayak MD PC-Warren	Warren	Michigan	United States	48093
545	Great Lakes Cancer Management Specialists-Macomb Professional Building	Warren	Michigan	United States	48093
546	Macomb Hematology Oncology PC	Warren	Michigan	United States	48093
547	Michigan Breast Specialists-Warren	Warren	Michigan	United States	48093
548	Saint John Macomb-Oakland Hospital	Warren	Michigan	United States	48093
549	Henry Ford West Bloomfield Hospital	West Bloomfield	Michigan	United States	48322
550	Saint Mary's Oncology/Hematology Associates of West Branch	West Branch	Michigan	United States	48661
551	Metro Health Hospital	Wyoming	Michigan	United States	49519
552	Huron Gastroenterology PC	Ypsilanti	Michigan	United States	48106
553	IHA Hematology Oncology Consultants-Ann Arbor	Ypsilanti	Michigan	United States	48197
554	Sanford Clinic North-Bemidgi	Bemidji	Minnesota	United States	56601
555	Essentia Health Saint Joseph's Medical Center	Brainerd	Minnesota	United States	56401
556	Fairview Ridges Hospital	Burnsville	Minnesota	United States	55337
557	Mercy Hospital	Coon Rapids	Minnesota	United States	55433
558	Essentia Health Cancer Center	Duluth	Minnesota	United States	55805
559	Essentia Health Saint Mary's Medical Center	Duluth	Minnesota	United States	55805
560	Miller-Dwan Hospital	Duluth	Minnesota	United States	55805
561	Fairview-Southdale Hospital	Edina	Minnesota	United States	55435
562	Lake Region Healthcare Corporation-Cancer Care	Fergus Falls	Minnesota	United States	56537
563	Unity Hospital	Fridley	Minnesota	United States	55432
564	Essentia Health Hibbing Clinic	Hibbing	Minnesota	United States	55746
565	Fairview Maple Grove Medical Center	Maple Grove	Minnesota	United States	55369
566	Minnesota Oncology Hematology PA-Maplewood	Maplewood	Minnesota	United States	55109
567	Saint John's Hospital - Healtheast	Maplewood	Minnesota	United States	55109
568	Abbott-Northwestern Hospital	Minneapolis	Minnesota	United States	55407
569	Hennepin County Medical Center	Minneapolis	Minnesota	United States	55415
570	Health Partners Inc	Minneapolis	Minnesota	United States	55454
571	New Ulm Medical Center	New Ulm	Minnesota	United States	56073
572	North Memorial Medical Health Center	Robbinsdale	Minnesota	United States	55422
573	Mayo Clinic	Rochester	Minnesota	United States	55905
574	Park Nicollet Clinic - Saint Louis Park	Saint Louis Park	Minnesota	United States	55416
575	Regions Hospital	Saint Paul	Minnesota	United States	55101
576	United Hospital	Saint Paul	Minnesota	United States	55102
577	Saint Francis Regional Medical Center	Shakopee	Minnesota	United States	55379
578	Lakeview Hospital	Stillwater	Minnesota	United States	55082
579	Essentia Health Virginia Clinic	Virginia	Minnesota	United States	55792
580	Ridgeview Medical Center	Waconia	Minnesota	United States	55387
581	Rice Memorial Hospital	Willmar	Minnesota	United States	56201
582	Minnesota Oncology Hematology PA-Woodbury	Woodbury	Minnesota	United States	55125
583	Fairview Lakes Medical Center	Wyoming	Minnesota	United States	55092
584	Baptist Memorial Hospital and Cancer Center-Golden Triangle	Columbus	Mississippi	United States	39705
585	Baptist Cancer Center-Grenada	Grenada	Mississippi	United States	38901
586	University of Mississippi Medical Center	Jackson	Mississippi	United States	39216
587	Baptist Memorial Hospital and Cancer Center-Union County	New Albany	Mississippi	United States	38652
588	Baptist Memorial Hospital and Cancer Center-Oxford	Oxford	Mississippi	United States	38655
589	Singing River Hospital	Pascagoula	Mississippi	United States	39581
590	Baptist Memorial Hospital and Cancer Center-Desoto	Southhaven	Mississippi	United States	38671
591	Saint Louis Cancer and Breast Institute-Ballwin	Ballwin	Missouri	United States	63011
592	Central Care Cancer Center - Bolivar	Bolivar	Missouri	United States	65613
593	Parkland Health Center-Bonne Terre	Bonne Terre	Missouri	United States	63628
594	Cox Cancer Center Branson	Branson	Missouri	United States	65616
595	Saint Francis Medical Center	Cape Girardeau	Missouri	United States	63703
596	Southeast Cancer Center	Cape Girardeau	Missouri	United States	63703
597	Saint Luke's Hospital	Chesterfield	Missouri	United States	63017
598	University of Missouri - Ellis Fischel	Columbia	Missouri	United States	65212
599	Siteman Cancer Center at West County Hospital	Creve Coeur	Missouri	United States	63141
600	Centerpoint Medical Center LLC	Independence	Missouri	United States	64057
601	Capital Region Southwest Campus	Jefferson City	Missouri	United States	65109
602	Freeman Health System	Joplin	Missouri	United States	64804
603	Mercy Hospital Joplin	Joplin	Missouri	United States	64804
604	Truman Medical Center	Kansas City	Missouri	United States	64108
605	Saint Luke's Hospital of Kansas City	Kansas City	Missouri	United States	64111
606	Heartland Hematology and Oncology Associates Incorporated	Kansas City	Missouri	United States	64118
607	Kansas City Veterans Affairs Medical Center	Kansas City	Missouri	United States	64128
608	The University of Kansas Cancer Center-South	Kansas City	Missouri	United States	64131
609	Research Medical Center	Kansas City	Missouri	United States	64132
610	The University of Kansas Cancer Center-North	Kansas City	Missouri	United States	64154
611	The University of Kansas Cancer Center-Lee's Summit	Lee's Summit	Missouri	United States	64064
612	Saint Luke's East - Lee's Summit	Lee's Summit	Missouri	United States	64086
613	Liberty Radiation Oncology Center	Liberty	Missouri	United States	64068
614	Delbert Day Cancer Institute at PCRMC	Rolla	Missouri	United States	65401
615	Mercy Clinic-Rolla-Cancer and Hematology	Rolla	Missouri	United States	65401
616	Heartland Regional Medical Center	Saint Joseph	Missouri	United States	64507
617	Saint Louis Cancer and Breast Institute-South City	Saint Louis	Missouri	United States	63109
618	Washington University School of Medicine	Saint Louis	Missouri	United States	63110
619	Siteman Cancer Center-South County	Saint Louis	Missouri	United States	63129
620	Missouri Baptist Medical Center	Saint Louis	Missouri	United States	63131
621	Siteman Cancer Center at Christian Hospital	Saint Louis	Missouri	United States	63136
622	Mercy Hospital Saint Louis	Saint Louis	Missouri	United States	63141
623	Siteman Cancer Center at Saint Peters Hospital	Saint Peters	Missouri	United States	63376
624	Sainte Genevieve County Memorial Hospital	Sainte Genevieve	Missouri	United States	63670
625	Mercy Hospital Springfield	Springfield	Missouri	United States	65804
626	CoxHealth South Hospital	Springfield	Missouri	United States	65807
627	Missouri Baptist Sullivan Hospital	Sullivan	Missouri	United States	63080
628	Missouri Baptist Outpatient Center-Sunset Hills	Sunset Hills	Missouri	United States	63127
629	Mercy Hospital Washington	Washington	Missouri	United States	63090
630	Community Hospital of Anaconda	Anaconda	Montana	United States	59711
631	Billings Clinic Cancer Center	Billings	Montana	United States	59101
632	Bozeman Deaconess Hospital	Bozeman	Montana	United States	59715
633	Benefis Healthcare- Sletten Cancer Institute	Great Falls	Montana	United States	59405
634	Great Falls Clinic	Great Falls	Montana	United States	59405
635	Saint Peter's Community Hospital	Helena	Montana	United States	59601
636	Kalispell Regional Medical Center	Kalispell	Montana	United States	59901
637	Community Medical Hospital	Missoula	Montana	United States	59804
638	Nebraska Medicine-Bellevue	Bellevue	Nebraska	United States	68123
639	CHI Health Saint Francis	Grand Island	Nebraska	United States	68803
640	Heartland Hematology and Oncology	Kearney	Nebraska	United States	68845
641	CHI Health Good Samaritan	Kearney	Nebraska	United States	68847
642	Nebraska Hematology and Oncology	Lincoln	Nebraska	United States	68506
643	Nebraska Cancer Research Center	Lincoln	Nebraska	United States	68510
644	Saint Elizabeth Regional Medical Center	Lincoln	Nebraska	United States	68510
645	Southeast Nebraska Cancer Center	Lincoln	Nebraska	United States	68510
646	Faith Regional Health Services Carson Cancer Center	Norfolk	Nebraska	United States	68701
647	Great Plains Health Callahan Cancer Center	North Platte	Nebraska	United States	69101
648	Nebraska Methodist Hospital	Omaha	Nebraska	United States	68114
649	Nebraska Medicine-Village Pointe	Omaha	Nebraska	United States	68118
650	Alegent Health Immanuel Medical Center	Omaha	Nebraska	United States	68122
651	Hematology and Oncology Consultants PC	Omaha	Nebraska	United States	68122
652	Alegent Health Bergan Mercy Medical Center	Omaha	Nebraska	United States	68124
653	Nebraska Cancer Specialists - Omaha	Omaha	Nebraska	United States	68124
654	Alegent Health Lakeside Hospital	Omaha	Nebraska	United States	68130
655	Oncology Hematology West PC	Omaha	Nebraska	United States	68130
656	Creighton University Medical Center	Omaha	Nebraska	United States	68131
657	University of Nebraska Medical Center	Omaha	Nebraska	United States	68198
658	Midlands Community Hospital	Papillion	Nebraska	United States	68046
659	Regional West Medical Center Cancer Center	Scottsbluff	Nebraska	United States	69361
660	Carson Tahoe Regional Medical Center	Carson City	Nevada	United States	89703
661	Cancer and Blood Specialists-Henderson	Henderson	Nevada	United States	89052
662	Comprehensive Cancer Centers of Nevada - Henderson	Henderson	Nevada	United States	89052
663	Comprehensive Cancer Centers of Nevada-Horizon Ridge	Henderson	Nevada	United States	89052
664	Las Vegas Cancer Center-Henderson	Henderson	Nevada	United States	89052
665	Nevada Cancer Specialists-Saint Rose	Henderson	Nevada	United States	89052
666	21st Century Oncology-Henderson	Henderson	Nevada	United States	89074
667	Comprehensive Cancer Centers of Nevada-Southeast Henderson	Henderson	Nevada	United States	89074
668	Desert West Surgery	Las Vegas	Nevada	United States	89102
669	Nevada Cancer Specialists?Oakey	Las Vegas	Nevada	United States	89102
670	University Medical Center of Southern Nevada	Las Vegas	Nevada	United States	89102
671	Cancer and Blood Specialists-Shadow	Las Vegas	Nevada	United States	89106
672	Radiation Oncology Centers of Nevada Central	Las Vegas	Nevada	United States	89106
673	21st Century Oncology	Las Vegas	Nevada	United States	89109
674	HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway	Las Vegas	Nevada	United States	89109
675	HealthCare Partners Medical Group Oncology/Hematology-San Martin	Las Vegas	Nevada	United States	89113
676	Radiation Oncology Centers of Nevada Southeast	Las Vegas	Nevada	United States	89119
677	Cancer Therapy and Integrative Medicine	Las Vegas	Nevada	United States	89121
678	21st Century Oncology-Vegas Tenaya	Las Vegas	Nevada	United States	89128
679	Ann M Wierman MD LTD	Las Vegas	Nevada	United States	89128
680	Cancer and Blood Specialists-Tenaya	Las Vegas	Nevada	United States	89128
681	Comprehensive Cancer Centers of Nevada - Northwest	Las Vegas	Nevada	United States	89128
682	HealthCare Partners Medical Group Oncology/Hematology-Tenaya	Las Vegas	Nevada	United States	89128
683	Nevada Cancer Specialists-Tenaya	Las Vegas	Nevada	United States	89128
684	Comprehensive Cancer Centers of Nevada-Summerlin	Las Vegas	Nevada	United States	89144
685	Summerlin Hospital Medical Center	Las Vegas	Nevada	United States	89144
686	Las Vegas Cancer Center-Medical Center	Las Vegas	Nevada	United States	89148-2405
687	21st Century Oncology-Fort Apache	Las Vegas	Nevada	United States	89148
688	Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	United States	89148
689	Nevada Cancer Specialists-Fort Apache	Las Vegas	Nevada	United States	89148
690	HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills	Las Vegas	Nevada	United States	89149
691	Comprehensive Cancer Centers of Nevada - Central Valley	Las Vegas	Nevada	United States	89169
692	University Cancer Center	Las Vegas	Nevada	United States	89169
693	Hope Cancer Care of Nevada-Pahrump	Pahrump	Nevada	United States	89048
694	Renown Regional Medical Center	Reno	Nevada	United States	89502
695	Saint Mary's Regional Medical Center	Reno	Nevada	United States	89503
696	Radiation Oncology Associates	Reno	Nevada	United States	89509
697	New Hampshire Oncology Hematology PA-Concord	Concord	New Hampshire	United States	03301
698	New Hampshire Oncology Hematology PA-Hooksett	Hooksett	New Hampshire	United States	03106
699	Dartmouth Hitchcock Medical Center	Lebanon	New Hampshire	United States	03756
700	Norris Cotton Cancer Center-Manchester	Manchester	New Hampshire	United States	03102
701	Ocean Medical Center	Brick	New Jersey	United States	08724
702	Bayshore Community Hospital	Holmdel	New Jersey	United States	07733
703	Southern Ocean County Medical Center	Manahawkin	New Jersey	United States	08050
704	Jersey Shore Medical Center	Neptune	New Jersey	United States	07753
705	Newark Beth Israel Medical Center	Newark	New Jersey	United States	07112
706	The Valley Hospital-Luckow Pavilion	Paramus	New Jersey	United States	07652
707	Riverview Medical Center/Booker Cancer Center	Red Bank	New Jersey	United States	07701
708	Neurosurgeons of New Jersey-Ridgewood	Ridgewood	New Jersey	United States	07450
709	Valley Hospital	Ridgewood	New Jersey	United States	07450
710	Robert Wood Johnson University Hospital Somerset	Somerville	New Jersey	United States	08876
711	Valley Health System-Hematology/Oncology	Westwood	New Jersey	United States	07675
712	Lovelace Medical Center-Downtown	Albuquerque	New Mexico	United States	87102
713	Lovelace Medical Center-Saint Joseph Square	Albuquerque	New Mexico	United States	87102
714	University of New Mexico Cancer Center	Albuquerque	New Mexico	United States	87102
715	New Mexico Oncology Hematology Consultants	Albuquerque	New Mexico	United States	87109
716	Memorial Medical Center - Las Cruces	Las Cruces	New Mexico	United States	88011
717	New York Oncology Hematology PC -Albany Medical Center	Albany	New York	United States	12208
718	Montefiore Medical Center-Einstein Campus	Bronx	New York	United States	10461
719	Montefiore Medical Center-Weiler Hospital	Bronx	New York	United States	10461
720	Montefiore Medical Center - Moses Campus	Bronx	New York	United States	10467
721	Bronx Veterans Administration Medical Center	Bronx	New York	United States	10468
722	State University of New York Downstate Medical Center	Brooklyn	New York	United States	11203
723	New York-Presbyterian/Brooklyn Methodist Hospital	Brooklyn	New York	United States	11215
724	Roswell Park Cancer Institute	Buffalo	New York	United States	14263
725	Mary Imogene Bassett Hospital	Cooperstown	New York	United States	13326
726	Arnot Ogden Medical Center/Falck Cancer Center	Elmira	New York	United States	14905
727	Glens Falls Hospital	Glens Falls	New York	United States	12801
728	Columbia University/Herbert Irving Cancer Center	New York	New York	United States	10032
729	University of Rochester	Rochester	New York	United States	14642
730	Stony Brook University Medical Center	Stony Brook	New York	United States	11794
731	State University of New York Upstate Medical University	Syracuse	New York	United States	13210
732	Faxton-Saint Luke's Healthcare	Utica	New York	United States	13502
733	Randolph Hospital	Asheboro	North Carolina	United States	27203
734	Cancer Care of Western North Carolina	Asheville	North Carolina	United States	28801
735	Mission Hospital Inc-Memorial Campus	Asheville	North Carolina	United States	28801
736	Asheville Hematology-Oncology Associates	Asheville	North Carolina	United States	28803
737	Cone Health Cancer Center at Alamance Regional	Burlington	North Carolina	United States	27215
738	Novant Health Presbyterian Medical Center	Charlotte	North Carolina	United States	28204
739	Oncology Specialists of Charlotte	Charlotte	North Carolina	United States	28207
740	Southern Oncology Specialists-Charlotte	Charlotte	North Carolina	United States	28262
741	Southeastern Medical Oncology Center-Clinton	Clinton	North Carolina	United States	28328
742	Haywood Infusion Center	Clyde	North Carolina	United States	28721
743	Duke University Medical Center	Durham	North Carolina	United States	27710
744	Cape Fear Valley Health System	Fayetteville	North Carolina	United States	28304
745	Southeastern Medical Oncology Center-Goldsboro	Goldsboro	North Carolina	United States	27534
746	Wayne Memorial Hospital	Goldsboro	North Carolina	United States	27534
747	Cone Health Cancer Center	Greensboro	North Carolina	United States	27403
748	Hendersonville Hematology and Oncology at Pardee	Hendersonville	North Carolina	United States	28791
749	Margaret R Pardee Memorial Hospital	Hendersonville	North Carolina	United States	28791
750	Park Ridge Health	Hendersonville	North Carolina	United States	28792
751	High Point Regional Hospital	High Point	North Carolina	United States	27262
752	Lake Norman Hematology Oncology Specialists-Huntersville	Huntersville	North Carolina	United States	28078
753	Southern Oncology Specialists-Huntersville	Huntersville	North Carolina	United States	28078
754	Onslow Memorial Hospital	Jacksonville	North Carolina	United States	28546
755	Southeastern Medical Oncology Center-Jacksonville	Jacksonville	North Carolina	United States	28546
756	Vidant Oncology-Kinston	Kinston	North Carolina	United States	28501
757	Matthews Radiation Oncology Center	Matthews	North Carolina	United States	28105
758	Novant Health Cancer Specialists-Matthews	Matthews	North Carolina	United States	28105
759	Cone Heath Cancer Center at Mebane	Mebane	North Carolina	United States	27302
760	Lake Norman Hematology Oncology Specialists-Mooresville	Mooresville	North Carolina	United States	28117
761	FirstHealth of the Carolinas-Moore Regional Hospital	Pinehurst	North Carolina	United States	28374
762	Duke Raleigh Hospital	Raleigh	North Carolina	United States	27609
763	Annie Penn Memorial Hospital	Reidsville	North Carolina	United States	27320
764	Southeastern Medical Oncology Center-Wilson	Wilson	North Carolina	United States	27893
765	Sanford Bismarck Medical Center	Bismarck	North Dakota	United States	58501
766	Essentia Health Cancer Center-South University Clinic	Fargo	North Dakota	United States	58103
767	Roger Maris Cancer Center	Fargo	North Dakota	United States	58122
768	Sanford Broadway Medical Center	Fargo	North Dakota	United States	58122
769	Sanford Clinic North-Fargo	Fargo	North Dakota	United States	58122
770	Trinity Cancer Care Center	Minot	North Dakota	United States	58701
771	Cleveland Clinic Cancer Center Beachwood	Beachwood	Ohio	United States	44122
772	UHHS-Chagrin Highlands Medical Center	Beachwood	Ohio	United States	44122
773	Indu and Raj Soin Medical Center	Beavercreek	Ohio	United States	45431
774	Strecker Cancer Center-Belpre	Belpre	Ohio	United States	45714
775	Mercy Medical Center	Canton	Ohio	United States	44708
776	Aultman Health Foundation	Canton	Ohio	United States	44710
777	Dayton Physicians LLC-Miami Valley South	Centerville	Ohio	United States	45459
778	Miami Valley Hospital South	Centerville	Ohio	United States	45459
779	Geauga Hospital	Chardon	Ohio	United States	44024
780	Adena Regional Medical Center	Chillicothe	Ohio	United States	45601
781	Oncology Hematology Care Inc-Eden Park	Cincinnati	Ohio	United States	45202
782	Oncology Hematology Care Inc-Mercy West	Cincinnati	Ohio	United States	45211
783	University of Cincinnati/Barrett Cancer Center	Cincinnati	Ohio	United States	45219
784	Good Samaritan Hospital - Cincinnati	Cincinnati	Ohio	United States	45220
785	Oncology Hematology Care Inc - Anderson	Cincinnati	Ohio	United States	45230
786	Oncology Hematology Care Inc-Kenwood	Cincinnati	Ohio	United States	45236
787	Bethesda North Hospital	Cincinnati	Ohio	United States	45242
788	Oncology Hematology Care Inc-Blue Ash	Cincinnati	Ohio	United States	45242
789	TriHealth Cancer Institute-Westside	Cincinnati	Ohio	United States	45247
790	TriHealth Cancer Institute-Anderson	Cincinnati	Ohio	United States	45255
791	Case Western Reserve University	Cleveland	Ohio	United States	44106
792	MetroHealth Medical Center	Cleveland	Ohio	United States	44109
793	Cleveland Clinic Cancer Center/Fairview Hospital	Cleveland	Ohio	United States	44111
794	Cleveland Clinic Foundation	Cleveland	Ohio	United States	44195
795	Ohio State University Comprehensive Cancer Center	Columbus	Ohio	United States	43210
796	Mount Carmel East Hospital	Columbus	Ohio	United States	43213
797	Columbus Oncology and Hematology Associates Inc	Columbus	Ohio	United States	43214
798	Riverside Methodist Hospital	Columbus	Ohio	United States	43214
799	Grant Medical Center	Columbus	Ohio	United States	43215
800	The Mark H Zangmeister Center	Columbus	Ohio	United States	43219
801	Mount Carmel Health Center West	Columbus	Ohio	United States	43222
802	Doctors Hospital	Columbus	Ohio	United States	43228
803	Good Samaritan Hospital - Dayton	Dayton	Ohio	United States	45406
804	Miami Valley Hospital	Dayton	Ohio	United States	45409
805	Dayton Physicians LLC-Samaritan North	Dayton	Ohio	United States	45415
806	Samaritan North Health Center	Dayton	Ohio	United States	45415
807	Delaware Health Center-Grady Cancer Center	Delaware	Ohio	United States	43015
808	Delaware Radiation Oncology	Delaware	Ohio	United States	43015
809	Grady Memorial Hospital	Delaware	Ohio	United States	43015
810	Mercy Cancer Center-Elyria	Elyria	Ohio	United States	44035
811	Oncology Hematology Care Inc-Healthplex	Fairfield	Ohio	United States	45014
812	Armes Family Cancer Center	Findlay	Ohio	United States	45840
813	Blanchard Valley Hospital	Findlay	Ohio	United States	45840
814	Orion Cancer Care	Findlay	Ohio	United States	45840
815	Atrium Medical Center-Middletown Regional Hospital	Franklin	Ohio	United States	45005-1066
816	Dayton Physicians LLC-Atrium	Franklin	Ohio	United States	45005
817	Dayton Physicians LLC-Wayne	Greenville	Ohio	United States	45331
818	Wayne Hospital	Greenville	Ohio	United States	45331
819	Cleveland Clinic Cancer Center Independence	Independence	Ohio	United States	44131
820	Greater Dayton Cancer Center	Kettering	Ohio	United States	45409
821	First Dayton Cancer Care	Kettering	Ohio	United States	45420
822	Kettering Medical Center	Kettering	Ohio	United States	45429
823	Fairfield Medical Center	Lancaster	Ohio	United States	43130
824	OhioHealth Mansfield Hospital	Mansfield	Ohio	United States	44903
825	Cleveland Clinic Cancer Center Mansfield	Mansfield	Ohio	United States	44906
826	Marietta Memorial Hospital	Marietta	Ohio	United States	45750
827	OhioHealth Marion General Hospital	Marion	Ohio	United States	43302
828	Hillcrest Hospital Cancer Center	Mayfield Heights	Ohio	United States	44124
829	Ireland Cancer Center Landerbrook Health Center	Mayfield Heights	Ohio	United States	44124
830	Lake University Ireland Cancer Center	Mentor	Ohio	United States	44060
831	Southwest General Health Center Ireland Cancer Center	Middleburg Heights	Ohio	United States	44130
832	Dayton Physicians LLC-Signal Point	Middletown	Ohio	United States	45042
833	Knox Community Hospital	Mount Vernon	Ohio	United States	43050
834	Licking Memorial Hospital	Newark	Ohio	United States	43055
835	Newark Radiation Oncology	Newark	Ohio	United States	43055
836	Southern Ohio Medical Center	Portsmouth	Ohio	United States	45662
837	Ireland Cancer Center at Firelands Regional Medical Center	Sandusky	Ohio	United States	44870
838	North Coast Cancer Care	Sandusky	Ohio	United States	44870
839	Dayton Physicians LLC-Wilson	Sidney	Ohio	United States	45365
840	Springfield Regional Cancer Center	Springfield	Ohio	United States	45504
841	Springfield Regional Medical Center	Springfield	Ohio	United States	45505
842	Trinity's Tony Teramana Cancer Center	Steubenville	Ohio	United States	43952
843	Cleveland Clinic Cancer Center Strongsville	Strongsville	Ohio	United States	44136
844	Flower Hospital	Sylvania	Ohio	United States	43560
845	The Toledo Hospital/Toledo Children's Hospital	Toledo	Ohio	United States	43606
846	University of Toledo	Toledo	Ohio	United States	43614
847	Dayton Physicians LLC-Upper Valley	Troy	Ohio	United States	45373
848	Upper Valley Medical Center	Troy	Ohio	United States	45373
849	University Hospitals Sharon Health Center	Wadsworth	Ohio	United States	44281
850	South Pointe Hospital	Warrensville Heights	Ohio	United States	44122
851	University Pointe	West Chester	Ohio	United States	45069
852	Saint Ann's Hospital	Westerville	Ohio	United States	43081
853	UH Seidman Cancer Center at Saint John Medical Center	Westlake	Ohio	United States	44145
854	UHHS-Westlake Medical Center	Westlake	Ohio	United States	44145
855	Cleveland Clinic Wooster Family Health and Surgery Center	Wooster	Ohio	United States	44691
856	Genesis Healthcare System Cancer Care Center	Zanesville	Ohio	United States	43701
857	Cancer Centers of Southwest Oklahoma Research	Lawton	Oklahoma	United States	73505
858	University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	United States	73104
859	Mercy Hospital Oklahoma City	Oklahoma City	Oklahoma	United States	73120
860	Oklahoma Cancer Specialists and Research Institute-Tulsa	Tulsa	Oklahoma	United States	74146
861	Saint Alphonsus Medical Center-Baker City	Baker City	Oregon	United States	97814
862	Saint Charles Health System	Bend	Oregon	United States	97701
863	Clackamas Radiation Oncology Center	Clackamas	Oregon	United States	97015
864	Providence Oncology and Hematology Care Southeast	Clackamas	Oregon	United States	97015
865	Bay Area Hospital	Coos Bay	Oregon	United States	97420
866	Legacy Mount Hood Medical Center	Gresham	Oregon	United States	97030
867	Providence Newberg Medical Center	Newberg	Oregon	United States	97132
868	Saint Alphonsus Medical Center-Ontario	Ontario	Oregon	United States	97914
869	Providence Willamette Falls Medical Center	Oregon City	Oregon	United States	97045
870	Legacy Good Samaritan Hospital and Medical Center	Portland	Oregon	United States	97210
871	Providence Portland Medical Center	Portland	Oregon	United States	97213
872	Providence Saint Vincent Medical Center	Portland	Oregon	United States	97225
873	Kaiser Permanente Northwest	Portland	Oregon	United States	97227
874	Oregon Health and Science University	Portland	Oregon	United States	97239
875	SWOG	Portland	Oregon	United States	97239
876	Saint Charles Health System-Redmond	Redmond	Oregon	United States	97756
877	Salem Hospital	Salem	Oregon	United States	97301
878	Lehigh Valley Hospital-Cedar Crest	Allentown	Pennsylvania	United States	18103
879	UPMC-Heritage Valley Health System Beaver	Beaver	Pennsylvania	United States	15009
880	Lehigh Valley Hospital - Muhlenberg	Bethlehem	Pennsylvania	United States	18017
881	Bryn Mawr Hospital	Bryn Mawr	Pennsylvania	United States	19010
882	Christiana Care Health System-Concord Health Center	Chadds Ford	Pennsylvania	United States	19317
883	Geisinger Medical Center	Danville	Pennsylvania	United States	17822
884	Ephrata Cancer Center	Ephrata	Pennsylvania	United States	17522
885	Ephrata Community Hospital	Ephrata	Pennsylvania	United States	17522
886	Adams Cancer Center	Gettysburg	Pennsylvania	United States	17325
887	UPMC Cancer Centers - Arnold Palmer Pavilion	Greensburg	Pennsylvania	United States	15601
888	Cherry Tree Cancer Center	Hanover	Pennsylvania	United States	17331
889	UPMC Pinnacle Cancer Center/Community Osteopathic Campus	Harrisburg	Pennsylvania	United States	17109
890	Geisinger Medical Center-Cancer Center Hazleton	Hazleton	Pennsylvania	United States	18201
891	Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	United States	17033-0850
892	Jefferson Hospital	Jefferson Hills	Pennsylvania	United States	15025
893	UPMC-Johnstown/John P. Murtha Regional Cancer Center	Johnstown	Pennsylvania	United States	15901
894	Armstrong Center for Medicine and Health	Kittanning	Pennsylvania	United States	16201
895	Sechler Family Cancer Center	Lebanon	Pennsylvania	United States	17042
896	Geisinger Medical Oncology-Lewisburg	Lewisburg	Pennsylvania	United States	17837
897	Lewistown Hospital	Lewistown	Pennsylvania	United States	17044
898	UPMC Cancer Center at UPMC McKeesport	McKeesport	Pennsylvania	United States	15132
899	Riddle Memorial Hospital	Media	Pennsylvania	United States	19063
900	Forbes Hospital	Monroeville	Pennsylvania	United States	15146
901	UPMC-Coraopolis/Heritage Valley Radiation Oncology	Moon	Pennsylvania	United States	15108
902	Allegheny Valley Hospital	Natrona Heights	Pennsylvania	United States	15065
903	Paoli Memorial Hospital	Paoli	Pennsylvania	United States	19301
904	University of Pennsylvania/Abramson Cancer Center	Philadelphia	Pennsylvania	United States	19104
905	Fox Chase Cancer Center	Philadelphia	Pennsylvania	United States	19111
906	Temple University Hospital	Philadelphia	Pennsylvania	United States	19140
907	Allegheny General Hospital	Pittsburgh	Pennsylvania	United States	15212
908	UPMC-Magee Womens Hospital	Pittsburgh	Pennsylvania	United States	15213
909	UPMC-Presbyterian Hospital	Pittsburgh	Pennsylvania	United States	15213
910	UPMC-Saint Margaret	Pittsburgh	Pennsylvania	United States	15215
911	West Penn Hospital	Pittsburgh	Pennsylvania	United States	15224
912	University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	United States	15232
913	UPMC-Shadyside Hospital	Pittsburgh	Pennsylvania	United States	15232
914	UPMC-Passavant Hospital	Pittsburgh	Pennsylvania	United States	15237
915	UPMC-Saint Clair Hospital Cancer Center	Pittsburgh	Pennsylvania	United States	15243
916	Pottstown Hospital	Pottstown	Pennsylvania	United States	19464
917	Geisinger Cancer Services-Pottsville	Pottsville	Pennsylvania	United States	17901
918	Penn State Health Saint Joseph Medical Center	Reading	Pennsylvania	United States	19605
919	Guthrie Medical Group PC-Robert Packer Hospital	Sayre	Pennsylvania	United States	18840
920	Community Medical Center	Scranton	Pennsylvania	United States	18510
921	Geisinger Medical Oncology-Selinsgrove	Selinsgrove	Pennsylvania	United States	17870
922	UPMC Cancer Center at UPMC Northwest	Seneca	Pennsylvania	United States	16346
923	Geisinger Medical Group	State College	Pennsylvania	United States	16801
924	UPMC Uniontown Hospital Radiation Oncology	Uniontown	Pennsylvania	United States	15401
925	UPMC Washington Hospital Radiation Oncology	Washington	Pennsylvania	United States	15301
926	Chester County Hospital	West Chester	Pennsylvania	United States	19380
927	Wexford Health and Wellness Pavilion	Wexford	Pennsylvania	United States	15090
928	Geisinger Wyoming Valley/Henry Cancer Center	Wilkes-Barre	Pennsylvania	United States	18711
929	UPMC Susquehanna	Williamsport	Pennsylvania	United States	17701
930	Lankenau Medical Center	Wynnewood	Pennsylvania	United States	19096
931	WellSpan Health-York Cancer Center	York	Pennsylvania	United States	17403
932	WellSpan Health-York Hospital	York	Pennsylvania	United States	17403
933	AnMed Health Cancer Center	Anderson	South Carolina	United States	29621
934	Roper Hospital	Charleston	South Carolina	United States	29401
935	Charleston Hematology Oncology Associates-Roper	Charleston	South Carolina	United States	29403
936	Lowcountry Hematology Oncology PA-North Charleston	Charleston	South Carolina	United States	29406
937	Bon Secours Saint Francis Hospital	Charleston	South Carolina	United States	29414
938	Charleston Hematology Oncology Associates PA-Saint Francis	Charleston	South Carolina	United States	29414
939	Lowcountry Hematology Oncology PA-West Ashley	Charleston	South Carolina	United States	29414
940	Greenville Health System Cancer Institute-Laurens	Clinton	South Carolina	United States	29325
941	Greenville Health System Cancer Institute-Easley	Easley	South Carolina	United States	29640
942	Gibbs Cancer Center-Gaffney	Gaffney	South Carolina	United States	29341
943	Tidelands Georgetown Memorial Hospital	Georgetown	South Carolina	United States	29440
944	Saint Francis Hospital	Greenville	South Carolina	United States	29601
945	Greenville Health System Cancer Institute-Butternut	Greenville	South Carolina	United States	29605
946	Greenville Health System Cancer Institute-Faris	Greenville	South Carolina	United States	29605
947	Greenville Memorial Hospital	Greenville	South Carolina	United States	29605
948	Saint Francis Cancer Center	Greenville	South Carolina	United States	29607
949	Greenville Health System Cancer Institute-Eastside	Greenville	South Carolina	United States	29615
950	Greenville Health System Cancer Institute-Greer	Greer	South Carolina	United States	29650
951	Gibbs Cancer Center-Pelham	Greer	South Carolina	United States	29651
952	Lowcountry Hematology Oncology PA-Mount Pleasant	Mount Pleasant	South Carolina	United States	29464
953	Greenville Health System Cancer Institute-Seneca	Seneca	South Carolina	United States	29672
954	Spartanburg Medical Center	Spartanburg	South Carolina	United States	29303
955	Greenville Health System Cancer Institute-Spartanburg	Spartanburg	South Carolina	United States	29307
956	MGC Hematology Oncology-Union	Union	South Carolina	United States	29379
957	Lexington Medical Center	West Columbia	South Carolina	United States	29169
958	Avera Cancer Institute-Aberdeen	Aberdeen	South Dakota	United States	57401
959	Rapid City Regional Hospital	Rapid City	South Dakota	United States	57701
960	Sanford Cancer Center Oncology Clinic	Sioux Falls	South Dakota	United States	57104
961	Avera Cancer Institute	Sioux Falls	South Dakota	United States	57105
962	Sanford USD Medical Center - Sioux Falls	Sioux Falls	South Dakota	United States	57117-5134
963	Boston Baskin Cancer Center-Bartlett	Bartlett	Tennessee	United States	38133
964	Memorial Hospital	Chattanooga	Tennessee	United States	37404
965	Cookeville Regional Medical Center	Cookeville	Tennessee	United States	38501
966	Vanderbilt-Ingram Cancer Center Cool Springs	Franklin	Tennessee	United States	37067
967	Pulmonary Medicine Center of Chattanooga-Hixson	Hixson	Tennessee	United States	37343
968	Thompson Cancer Survival Center	Knoxville	Tennessee	United States	37916
969	Thompson Cancer Survival Center - West	Knoxville	Tennessee	United States	37932
970	Baptist Memorial Hospital and Cancer Center-Memphis	Memphis	Tennessee	United States	38120
971	Baptist Memorial Hospital for Women	Memphis	Tennessee	United States	38120
972	Family Cancer Center-Memphis	Memphis	Tennessee	United States	38120
973	Vanderbilt Breast Center at One Hundred Oaks	Nashville	Tennessee	United States	37204
974	Meharry Medical College	Nashville	Tennessee	United States	37208
975	Vanderbilt University/Ingram Cancer Center	Nashville	Tennessee	United States	37232
976	Thompson Oncology Group-Oak Ridge	Oak Ridge	Tennessee	United States	37830
977	Memorial GYN Plus	Ooltewah	Tennessee	United States	37363
978	The Don and Sybil Harrington Cancer Center	Amarillo	Texas	United States	79106
979	Saint Joseph Regional Cancer Center	Bryan	Texas	United States	77802
980	Parkland Memorial Hospital	Dallas	Texas	United States	75235
981	UT Southwestern/Simmons Cancer Center-Dallas	Dallas	Texas	United States	75390
982	Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center	Houston	Texas	United States	77030
983	Ben Taub General Hospital	Houston	Texas	United States	77030
984	M D Anderson Cancer Center	Houston	Texas	United States	77030
985	Michael E DeBakey VA Medical Center	Houston	Texas	United States	77030
986	The Methodist Hospital System	Houston	Texas	United States	77030
987	Covenant Medical Center-Lakeside	Lubbock	Texas	United States	79410
988	University Medical Center	Lubbock	Texas	United States	79415
989	Texas Tech University Health Sciences Center-Lubbock	Lubbock	Texas	United States	79430
990	University of Texas Health Science Center at San Antonio	San Antonio	Texas	United States	78229
991	American Fork Hospital / Huntsman Intermountain Cancer Center	American Fork	Utah	United States	84003
992	Sandra L Maxwell Cancer Center	Cedar City	Utah	United States	84720
993	Logan Regional Hospital	Logan	Utah	United States	84321
994	Intermountain Medical Center	Murray	Utah	United States	84107
995	McKay-Dee Hospital Center	Ogden	Utah	United States	84403
996	Utah Valley Regional Medical Center	Provo	Utah	United States	84604
997	Riverton Hospital	Riverton	Utah	United States	84065
998	Dixie Medical Center Regional Cancer Center	Saint George	Utah	United States	84770
999	Utah Cancer Specialists-Salt Lake City	Salt Lake City	Utah	United States	84106
1000	LDS Hospital	Salt Lake City	Utah	United States	84143
1001	Central Vermont Medical Center/National Life Cancer Treatment	Berlin	Vermont	United States	05602
1002	University of Vermont Medical Center	Burlington	Vermont	United States	05401
1003	University of Vermont College of Medicine	Burlington	Vermont	United States	05405
1004	Kaiser Permanente-Burke Medical Center	Burke	Virginia	United States	22015
1005	University of Virginia Cancer Center	Charlottesville	Virginia	United States	22908
1006	Hematology Oncology Associates of Fredericksburg Inc	Fredericksburg	Virginia	United States	22408
1007	Lynchburg Hematology-Oncology Clinic	Lynchburg	Virginia	United States	24501
1008	Sovah Health Martinsville	Martinsville	Virginia	United States	24115
1009	Kaiser Permanente Tysons Corner Medical Center	McLean	Virginia	United States	22102
1010	Bon Secours Memorial Regional Medical Center	Mechanicsville	Virginia	United States	23116
1011	Bon Secours Saint Francis Medical Center	Midlothian	Virginia	United States	23114
1012	Bon Secours Saint Mary's Hospital	Richmond	Virginia	United States	23226
1013	Virginia Cancer Institute	Richmond	Virginia	United States	23230
1014	Virginia Commonwealth University/Massey Cancer Center	Richmond	Virginia	United States	23298
1015	VCU Community Memorial Health Center	South Hill	Virginia	United States	23970
1016	Shenandoah Oncology PC	Winchester	Virginia	United States	22601
1017	Providence Regional Cancer System-Aberdeen	Aberdeen	Washington	United States	98520
1018	Cancer Care Center at Island Hospital	Anacortes	Washington	United States	98221
1019	MultiCare Auburn Medical Center	Auburn	Washington	United States	98001
1020	Virginia Mason Bainbridge Island Medical Center	Bainbridge Island	Washington	United States	98110
1021	Overlake Hospital Medical Center	Bellevue	Washington	United States	98004
1022	PeaceHealth Saint Joseph Medical Center	Bellingham	Washington	United States	98225
1023	Harrison HealthPartners Hematology and Oncology-Bremerton	Bremerton	Washington	United States	98310
1024	Harrison Medical Center	Bremerton	Washington	United States	98310
1025	Highline Medical Center-Main Campus	Burien	Washington	United States	98166
1026	Providence Regional Cancer System-Centralia	Centralia	Washington	United States	98531
1027	Swedish Medical Center-Edmonds	Edmonds	Washington	United States	98026
1028	Saint Elizabeth Hospital	Enumclaw	Washington	United States	98022
1029	Providence Regional Cancer Partnership	Everett	Washington	United States	98201
1030	Virginia Mason Federal Way Medical Center	Federal Way	Washington	United States	98002
1031	Saint Francis Hospital	Federal Way	Washington	United States	98003
1032	Tacoma/Valley Radiation Oncology Centers-Gig Harbor	Gig Harbor	Washington	United States	98332
1033	MultiCare Gig Harbor Medical Park	Gig Harbor	Washington	United States	98335
1034	Swedish Cancer Institute-Issaquah	Issaquah	Washington	United States	98029
1035	Kadlec Clinic Hematology and Oncology	Kennewick	Washington	United States	99336
1036	Northwest Cancer Clinic	Kennewick	Washington	United States	99336
1037	Seattle Cancer Care Alliance at EvergreenHealth	Kirkland	Washington	United States	98034
1038	Providence Regional Cancer System-Lacey	Lacey	Washington	United States	98503
1039	Saint Clare Hospital	Lakewood	Washington	United States	98499
1040	PeaceHealth Saint John Medical Center	Longview	Washington	United States	98632
1041	Virginia Mason Lynnwood Medical Center	Lynnwood	Washington	United States	98036
1042	Skagit Valley Hospital Regional Cancer Care Center	Mount Vernon	Washington	United States	98273
1043	Skagit Valley Hospital	Mount Vernon	Washington	United States	98274
1044	Jefferson Healthcare	Port Townsend	Washington	United States	98368
1045	Harrison HealthPartners Hematology and Oncology-Poulsbo	Poulsbo	Washington	United States	98370
1046	Peninsula Cancer Center	Poulsbo	Washington	United States	98370
1047	MultiCare Good Samaritan Hospital	Puyallup	Washington	United States	98372
1048	Tacoma/Valley Radiation Oncology Centers-Puyallup	Puyallup	Washington	United States	98372
1049	Valley Medical Center	Renton	Washington	United States	98055
1050	Virginia Mason Medical Center	Seattle	Washington	United States	98101
1051	Pacific Gynecology Specialists	Seattle	Washington	United States	98104
1052	Swedish Medical Center-Ballard Campus	Seattle	Washington	United States	98107
1053	Fred Hutchinson Cancer Research Center	Seattle	Washington	United States	98109
1054	Seattle Cancer Care Alliance	Seattle	Washington	United States	98109
1055	Kaiser Permanente Washington	Seattle	Washington	United States	98112
1056	Swedish Medical Center-First Hill	Seattle	Washington	United States	98122-4307
1057	Seattle Cancer Care Alliance at Northwest Hospital	Seattle	Washington	United States	98133
1058	University of Washington Medical Center	Seattle	Washington	United States	98195
1059	PeaceHealth United General Medical Center	Sedro-Woolley	Washington	United States	98284
1060	Providence Regional Cancer System-Shelton	Shelton	Washington	United States	98584
1061	Rockwood Clinic Cancer Treatment Center-Valley	Spokane Valley	Washington	United States	99216
1062	Cancer Care Northwest - Spokane South	Spokane	Washington	United States	99202
1063	Rockwood Cancer Treatment Center-DHEC-Downtown	Spokane	Washington	United States	99204
1064	Spokane Valley Cancer Center-Mayfair	Spokane	Washington	United States	99208
1065	Cancer Care Northwest-Valley	Spokane	Washington	United States	99216
1066	Spokane Valley Cancer Center-Mission	Spokane	Washington	United States	99216
1067	Cancer Care Northwest-North Spokane	Spokane	Washington	United States	99218
1068	Rockwood North Cancer Treatment Center	Spokane	Washington	United States	99218
1069	Tacoma/Valley Radiation Oncology Centers-Jackson Hall	Tacoma	Washington	United States	97405
1070	Franciscan Research Center-Northwest Medical Plaza	Tacoma	Washington	United States	98405
1071	MultiCare Tacoma General Hospital	Tacoma	Washington	United States	98405
1072	Northwest Medical Specialties PLLC	Tacoma	Washington	United States	98405
1073	Tacoma/Valley Radiation Oncology Centers-Saint Joe's	Tacoma	Washington	United States	98405
1074	PeaceHealth Southwest Medical Center	Vancouver	Washington	United States	98664
1075	Legacy Salmon Creek Hospital	Vancouver	Washington	United States	98686
1076	Providence Saint Mary Regional Cancer Center	Walla Walla	Washington	United States	99362
1077	Wenatchee Valley Hospital and Clinics	Wenatchee	Washington	United States	98801
1078	North Star Lodge Cancer Center at Yakima Valley Memorial Hospital	Yakima	Washington	United States	98902
1079	Providence Regional Cancer System-Yelm	Yelm	Washington	United States	98597
1080	United Hospital Center	Bridgeport	West Virginia	United States	26330
1081	West Virginia University Charleston Division	Charleston	West Virginia	United States	25304
1082	Edwards Comprehensive Cancer Center	Huntington	West Virginia	United States	25701
1083	Saint Mary's Medical Center	Huntington	West Virginia	United States	25702
1084	WVUH-Berkely Medical Center	Martinsburg	West Virginia	United States	25401
1085	West Virginia University Healthcare	Morgantown	West Virginia	United States	26506
1086	Camden Clark Medical Center	Parkersburg	West Virginia	United States	26101
1087	Langlade Hospital and Cancer Center	Antigo	Wisconsin	United States	54409
1088	Duluth Clinic Ashland	Ashland	Wisconsin	United States	54806
1089	Aurora Cancer Care-Southern Lakes VLCC	Burlington	Wisconsin	United States	53105
1090	Marshfield Clinic-Chippewa Center	Chippewa Falls	Wisconsin	United States	54729
1091	HSHS Sacred Heart Hospital	Eau Claire	Wisconsin	United States	54701
1092	Marshfield Clinic Cancer Center - Eau Claire	Eau Claire	Wisconsin	United States	54701
1093	Marshfield Clinic Cancer Center at Sacred Heart	Eau Claire	Wisconsin	United States	54701
1094	Aurora Health Center-Fond du Lac	Fond Du Lac	Wisconsin	United States	54937
1095	Aurora Health Care Germantown Health Center	Germantown	Wisconsin	United States	53022
1096	Aurora Cancer Care-Grafton	Grafton	Wisconsin	United States	53024
1097	Green Bay Oncology at Saint Vincent Hospital	Green Bay	Wisconsin	United States	54301-3526
1098	Saint Vincent Hospital Cancer Center Green Bay	Green Bay	Wisconsin	United States	54301
1099	Green Bay Oncology Limited at Saint Mary's Hospital	Green Bay	Wisconsin	United States	54303
1100	Saint Vincent Hospital Cancer Center at Saint Mary's	Green Bay	Wisconsin	United States	54303
1101	Aurora BayCare Medical Center	Green Bay	Wisconsin	United States	54311
1102	Mercy Health System	Janesville	Wisconsin	United States	53547
1103	UW Cancer Center Johnson Creek	Johnson Creek	Wisconsin	United States	53038
1104	Aurora Cancer Care-Kenosha South	Kenosha	Wisconsin	United States	53142
1105	Gundersen Lutheran Medical Center	La Crosse	Wisconsin	United States	54601
1106	Marshfield Clinic - Ladysmith Center	Ladysmith	Wisconsin	United States	54848
1107	University of Wisconsin Hospital and Clinics	Madison	Wisconsin	United States	53792
1108	Holy Family Memorial Hospital	Manitowoc	Wisconsin	United States	54221
1109	Aurora Bay Area Medical Group-Marinette	Marinette	Wisconsin	United States	54143
1110	Saint Vincent Hospital Cancer Center at Marinette	Marinette	Wisconsin	United States	54143
1111	Vince Lombardi Cancer Clinic-Marinette	Marinette	Wisconsin	United States	54143
1112	Marshfield Clinic	Marshfield	Wisconsin	United States	54449
1113	Marshfield Medical Center	Marshfield	Wisconsin	United States	54449
1114	Community Memorial Hospital	Menomonee Falls	Wisconsin	United States	53051
1115	Aurora Cancer Care-Milwaukee	Milwaukee	Wisconsin	United States	53209
1116	Aurora Saint Luke's Medical Center	Milwaukee	Wisconsin	United States	53215
1117	Froedtert and the Medical College of Wisconsin	Milwaukee	Wisconsin	United States	53226
1118	Aurora Sinai Medical Center	Milwaukee	Wisconsin	United States	53233
1119	Marshfield Clinic-Minocqua Center	Minocqua	Wisconsin	United States	54548
1120	ProHealth D N Greenwald Center	Mukwonago	Wisconsin	United States	53149
1121	Cancer Center of Western Wisconsin	New Richmond	Wisconsin	United States	54017
1122	ProHealth Oconomowoc Memorial Hospital	Oconomowoc	Wisconsin	United States	53066
1123	Green Bay Oncology - Oconto Falls	Oconto Falls	Wisconsin	United States	54154
1124	Vince Lombardi Cancer Clinic - Oshkosh	Oshkosh	Wisconsin	United States	54904
1125	Aurora Cancer Care-Racine	Racine	Wisconsin	United States	53406
1126	Lakeview Medical Center-Marshfield Clinic	Rice Lake	Wisconsin	United States	54868
1127	Marshfield Clinic-Rice Lake Center	Rice Lake	Wisconsin	United States	54868
1128	HSHS Saint Nicholas Hospital	Sheboygan	Wisconsin	United States	53081
1129	Vince Lombardi Cancer Clinic-Sheboygan	Sheboygan	Wisconsin	United States	53081
1130	Ascension Saint Michael's Hospital	Stevens Point	Wisconsin	United States	54481
1131	Saint Michael's Hospital	Stevens Point	Wisconsin	United States	54481
1132	Marshfield Clinic Stevens Point Center	Stevens Point	Wisconsin	United States	54482
1133	Saint Vincent Hospital Cancer Center at Sturgeon Bay	Sturgeon Bay	Wisconsin	United States	54235-1495
1134	Green Bay Oncology - Sturgeon Bay	Sturgeon Bay	Wisconsin	United States	54235
1135	Aurora Medical Center in Summit	Summit	Wisconsin	United States	53066
1136	Vince Lombardi Cancer Clinic-Two Rivers	Two Rivers	Wisconsin	United States	54241
1137	ProHealth Waukesha Memorial Hospital	Waukesha	Wisconsin	United States	53188
1138	UW Cancer Center at ProHealth Care	Waukesha	Wisconsin	United States	53188
1139	Aspirus Regional Cancer Center	Wausau	Wisconsin	United States	54401
1140	Marshfield Clinic-Wausau Center	Wausau	Wisconsin	United States	54401
1141	Aurora Cancer Care-Milwaukee West	Wauwatosa	Wisconsin	United States	53226
1142	Aurora West Allis Medical Center	West Allis	Wisconsin	United States	53227
1143	The Alyce and Elmore Kraemer Cancer Care Center	West Bend	Wisconsin	United States	53095
1144	Diagnostic and Treatment Center	Weston	Wisconsin	United States	54476
1145	Marshfield Clinic - Weston Center	Weston	Wisconsin	United States	54476
1146	Saint Clare's Hospital	Weston	Wisconsin	United States	54476
1147	Aspirus UW Cancer Center	Wisconsin Rapids	Wisconsin	United States	54494
1148	Marshfield Clinic - Wisconsin Rapids Center	Wisconsin Rapids	Wisconsin	United States	54494
1149	Cheyenne Regional Medical Center-West	Cheyenne	Wyoming	United States	82001
1150	Billings Clinic-Cody	Cody	Wyoming	United States	82414
1151	Welch Cancer Center	Sheridan	Wyoming	United States	82801
1152	Cross Cancer Institute	Edmonton	Alberta	Canada	T6G 1Z2
1153	Juravinski Cancer Centre at Hamilton Health Sciences	Hamilton	Ontario	Canada	L8V 5C2
1154	Ottawa Hospital and Cancer Center-General Campus	Ottawa	Ontario	Canada	K1H 8L6
1155	University Health Network-Princess Margaret Hospital	Toronto	Ontario	Canada	M5G 2M9
1156	Allan Blair Cancer Centre	Regina	Saskatchewan	Canada	S4T 7T1
1157	Saskatoon Cancer Centre	Saskatoon	Saskatchewan	Canada	S7N 4H4

Sponsors and Collaborators

• Southwest Oncology Group
• National Cancer Institute (NCI)

Investigators

• Principal Investigator: Vassiliki Papadimitrakopoulou, Southwest Oncology Group

Study Documents (Full-Text)

• Study Protocol and Statistical Analysis Plan - Jul 19, 2019
• Informed Consent Form - Jul 19, 2019

More Information

Publications

None provided.

• Responsible Party: Southwest Oncology Group
• ClinicalTrials.gov Identifier: NCT03377556
• Other Study ID Numbers: S1400G; NCI-2017-00135; S1400G; S1400G; S1400G; U10CA180888
• First Posted: Dec 19, 2017
• Last Update Posted: Jun 23, 2021
• Last Verified: Jun 1, 2021

• Studies a U.S. FDA-regulated Drug Product: Yes
• Studies a U.S. FDA-regulated Device Product: No
• Additional relevant MeSH terms: Carcinoma; Lung Neoplasms; Talazoparib

Study Results

Participant Flow

Pre-assignment Detail

51 participants were enrolled. 3 participants were ineligible due to progression on first-line platinum-based chemotherapy or not receiving prior platinum-based chemotherapy and 1 participant died before receiving protocol treatment. Thus, only 47 participants were eligible. Analyses were done for 2 participant populations-: i) eligible HRRD-positive participants per Foundation Medicine Inc. criteria (FMI) - 47 ii) eligible HRRD-positive participants per Medivation (MDVN) criteria - 24

Arm/Group Title	Talazoparib
Arm/Group Description	Participants receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Pharmacological Study: Correlative studies Talazoparib: Given PO
Period Title: Overall Study
STARTED	47
Primary Analysis Population (HRRD-positive Per MDVN Criteria)	24
COMPLETED	0
NOT COMPLETED	47

Baseline Characteristics

Arm/Group Title	Talazoparib
Arm/Group Description	Participants receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Pharmacological Study: Correlative studies Talazoparib: Given PO
Overall Participants	47
Age (years) [Median (Full Range) ]
Median (Full Range) [years]	66.7
Sex: Female, Male (Count of Participants)
Female	8 17%
Male	39 83%
Ethnicity (NIH/OMB) (Count of Participants)
Hispanic or Latino	2 4.3%
Not Hispanic or Latino	44 93.6%
Unknown or Not Reported	1 2.1%
Race (NIH/OMB) (Count of Participants)
American Indian or Alaska Native	0 0%
Asian	0 0%
Native Hawaiian or Other Pacific Islander	0 0%
Black or African American	7 14.9%
White	40 85.1%
More than one race	0 0%
Unknown or Not Reported	0 0%
Performance status (Count of Participants)
0	10 21.3%
1	37 78.7%
Number of prior lines of therapy for stage IV disease (Count of Participants)
0	11 23.4%
1	13 27.7%
>=2	23 48.9%
Smoking status (Count of Participants)
Current smoker	7 14.9%
Recent smoker	8 17%
Former smoker	31 66%
Never smoker	1 2.1%

Outcome Measures

1. Primary Outcome

Title	Overall Response Rate Assessed by Response Evaluation Criteria in Solid Tumors 1.1 in HRRD-positive (MDVN) Participants
Description	The percentage of participants with confirmed and unconfirmed, partial response and complete response to treatment with talazoparib per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1). Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) for target lesions and assessed by MRI or CT: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR Analysis was performed using a more restricted definition of homologous recombination repair deficiency (HRRD)-positivity (Medivation [MDVN] criteria; defined by alterations in ATM/ATR/BRCA1/BRCA2/PALB2 genes). With 40 HRRD subset positive patients, overall response rate can be estimated within 13% with 95% confidence.
Time Frame	Up to 3 years post sub-study registration

Outcome Measure Data

Analysis Population Description

Participants that meet the MDVN criteria for homologous recombination repair deficiency (HRRD)

Arm/Group Title	Talazoparib
Arm/Group Description	Participants receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Pharmacological Study: Correlative studies Talazoparib: Given PO
Measure Participants	24
Number (95% Confidence Interval) [percentage of participants]	4 8.5%

2. Secondary Outcome

Title	Investigator-assessed Progression-free Survival (IA-PFS) in HRRD-positive (MDVN) Participants
Description	From date of sub-study registration to date of first documentation of progression assessed by local review or symptomatic deterioration or death due to any cause. Participants last known to be alive without report of progression were censored at date of last disease assessment. Analysis was performed using a more restricted definition of homologous recombination repair deficiency (HRRD)-positivity (Medivation [MDVN] criteria; defined by alterations in ATM/ATR/BRCA1/BRCA2/PALB2 genes).
Time Frame	Up to 3 years post sub-study registration

Outcome Measure Data

Analysis Population Description

Eligible participants that meet the MDVN criteria for homologous recombination repair deficiency (HRRD)

Arm/Group Title	Talazoparib
Arm/Group Description	Participants receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Pharmacological Study: Correlative studies Talazoparib: Given PO
Measure Participants	24
Median (95% Confidence Interval) [months]	2.4

3. Secondary Outcome

Title	Overall Survival (OS) in HRRD-positive (MDVN) Participants
Description	From date of sub-study registration to date of death due to any cause. Participants last known to be alive were censored at date of last contact. Analysis was performed using a more restricted definition of homologous recombination repair deficiency (HRRD)-positivity (Medivation [MDVN] criteria; defined by alterations in ATM/ATR/BRCA1/BRCA2/PALB2 genes).
Time Frame	Up to 3 years post sub-study registration

Outcome Measure Data

Analysis Population Description

Participants that meet the MDVN criteria for homologous recombination repair deficiency (HRRD)

Arm/Group Title	Talazoparib
Arm/Group Description	Participants receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Pharmacological Study: Correlative studies Talazoparib: Given PO
Measure Participants	24
Median (95% Confidence Interval) [months]	5.2

4. Secondary Outcome

Title	Overall Response Rate Assessed by Response Evaluation Criteria in Solid Tumors 1.1 in HRRD-positive (FMI) Participants
Description	The percentage of participants with confirmed and unconfirmed, partial response and complete response to treatment with talazoparib per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1). Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) for target lesions and assessed by MRI or CT: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR Analysis was performed using a broader definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc. [FMI] criteria; defined by alterations in ATM/ATR/BARD1/BRCA1/BRCA2/BRIP1/CHEK1/CHEK2/FANCA/FANCC/FANCD2/FANCF/FANCM/NBN(NBS1)/PALB2/RAD51/RAD51B(RAD51L1)/RAD54L/RPA1 genes).
Time Frame	3 years post sub-study registration

Outcome Measure Data

Analysis Population Description

All eligible participants that meet a broad definition of homologous recombination repair deficiency (HRRD) -positivity (Foundation Medicine Inc. [FMI] criteria).

Arm/Group Title	Talazoparib
Arm/Group Description	Participants receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Pharmacological Study: Correlative studies Talazoparib: Given PO
Measure Participants	47
Number (95% Confidence Interval) [percentage of participants]	11 23.4%

5. Secondary Outcome

Title	Investigator-assessed Progression Free Survival (IA-PFS) FEP in HRRD-positive (FMI) Participants
Description	From date of sub-study registration to date of first documentation of progression assessed by local review or symptomatic deterioration or death due to any cause. Participants last known to be alive without report of progression were censored at date of last disease assessment. Analysis was performed using a broader definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc. [FMI] criteria; defined by alterations in ATM/ATR/BARD1/BRCA1/BRCA2/BRIP1/CHEK1/CHEK2/FANCA/FANCC/FANCD2/FANCF/FANCM/NBN(NBS1)/PALB2/RAD51/RAD51B(RAD51L1)/RAD54L/RPA1 genes).
Time Frame	3 years post sub-study registration

Outcome Measure Data

Analysis Population Description

All eligible participants that meet the FMI criteria for homologous recombination repair deficiency (HRRD)

Arm/Group Title	Talazoparib
Arm/Group Description	Participants receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Pharmacological Study: Correlative studies Talazoparib: Given PO
Measure Participants	47
Median (95% Confidence Interval) [months]	2.5

6. Secondary Outcome

Title	Overall Survival (OS) in HRRD-positive (FMI) Participants
Description	From date of sub-study registration to date of death due to any cause. Participants last known to be alive were censored at date of last contact. Analysis was performed using a broad definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc. [FMI] criteria; defined by alterations in ATM/ATR/BARD1/BRCA1/BRCA2/BRIP1/CHEK1/CHEK2/FANCA/FANCC/FANCD2/FANCF/FANCM/NBN(NBS1)/PALB2/RAD51/RAD51B(RAD51L1)/RAD54L/RPA1 genes).
Time Frame	3 years post sub-study registration

Outcome Measure Data

Analysis Population Description

All eligible participants that meet the FMI criteria for homologous recombination repair deficiency (HRRD)

Arm/Group Title	Talazoparib
Arm/Group Description	Participants receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Pharmacological Study: Correlative studies Talazoparib: Given PO
Measure Participants	47
Median (95% Confidence Interval) [months]	5.7

7. Secondary Outcome

Title	Duration of Response in HRRD-positive (FMI) Participants
Description	From date of documentation of response (complete or partial) to date of first documentation of progression assessed by local review or symptomatic deterioration or death due to any cause among participants who achieve a complete or partial response.
Time Frame	Up to 3 years

Outcome Measure Data

Analysis Population Description

All eligible participants that meet the FMI criteria for homologous recombination repair deficiency (HRRD)

Arm/Group Title	Talazoparib
Arm/Group Description	Participants receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Pharmacological Study: Correlative studies Talazoparib: Given PO
Measure Participants	47
Median (95% Confidence Interval) [months]	1.8

8. Secondary Outcome

Title	Overall Response Rate Assessed by Response Evaluation Criteria in Solid Tumors 1.1 in HRRD-negative Per MDVN But HRRD-positive Per FMI Participants
Description	The percentage of participants with confirmed and unconfirmed, partial response and complete response to treatment with talazoparib per Response Evaluation Criteria in Solid Tumors Criteria (RECIST 1.1). Per Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.1) for target lesions and assessed by MRI or CT: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR Analysis was performed on participants that meet a broader definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc.) but not the stricter definition set by MDVN. [FMI] criteria; defined by alterations in ATM/ATR/BARD1/BRCA1/BRCA2/BRIP1/CHEK1/CHEK2/FANCA/FANCC/FANCD2/FANCF/FANCM/NBN(NBS1)/PALB2/RAD51/RAD51B(RAD51L1)/RAD54L/RPA1 genes).
Time Frame	3 years post sub-study registration

Outcome Measure Data

Analysis Population Description

All eligible participants that meet a broad definition of homologous recombination repair deficiency (HRRD)-positivity (Foundation Medicine Inc. [FMI] criteria), but do not meet the more restrictive MDVN criteria for HRRD positivity.

Arm/Group Title	Talazoparib
Arm/Group Description	Participants receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Pharmacological Study: Correlative studies Talazoparib: Given PO
Measure Participants	23
Number (95% Confidence Interval) [percentage of participants]	17 36.2%

9. Secondary Outcome

Title	Number of Participants With Gr 3 Through 5 Adverse Events That Are Related to Study Drugs
Description	Adverse Events (AEs) are reported by CTCAE Version 4.0. Only adverse events that are possibly, probably or definitely related to study drug are reported.
Time Frame	Duration of treatment and follow up until death or 3 years post registration

Outcome Measure Data

Analysis Population Description

Participants who received at least one dose of talazoparib treatment.

Arm/Group Title	Talazoparib
Arm/Group Description	Participants receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Pharmacological Study: Correlative studies Talazoparib: Given PO
Measure Participants	47
Alanine aminotransferase increased	1 2.1%
Anemia	7 14.9%
Aspartate aminotransferase increased	1 2.1%
Dehydration	1 2.1%
Dyspnea	1 2.1%
Fatigue	2 4.3%
Generalized muscle weakness	1 2.1%
Hypertension	1 2.1%
Hypoalbuminemia	1 2.1%
Hyponatremia	2 4.3%
Hypotension	1 2.1%
Hypoxia	1 2.1%
Lung infection	1 2.1%
Lymphocyte count decreased	4 8.5%
Nausea	3 6.4%
Neutrophil count decreased	1 2.1%
Platelet count decreased	6 12.8%
Respiratory failure	1 2.1%
Sepsis	1 2.1%
Vomiting	1 2.1%
White blood cell decreased	1 2.1%
Wound infection	1 2.1%

10. Other Pre-specified Outcome

Title	Homologous Recombination Deficiency (HRD) Immunohistochemistry Score
Description	A logistic regression model will be used as both a continuous variable and categorized as high versus low. A Cox regression model will be used to assess associations with progression free survival and overall survival.
Time Frame	Up to 3 years

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

11. Other Pre-specified Outcome

Title	PARP Protein Expression Levels Assessed by Immunohistochemistry
Description	A logistic regression model will be used to evaluate if HRD score (as both a continuous variable and categorized as high versus low) and PARP protein expression levels are associated with response. Similarly, a Cox regression model will be used to assess associations with progression free survival and overall survival.
Time Frame	Up to 3 years

Outcome Measure Data

Analysis Population Description

[Not Specified]

Arm/Group Title

Arm/Group Description

Adverse Events

Time Frame	Duration of treatment and follow up until death or 3 years post-registration
Adverse Event Reporting Description	47 participants that were eligible and received protocol therapy were assessed for AEs
Arm/Group Title	Talazoparib
Arm/Group Description	Participants receive talazoparib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Laboratory Biomarker Analysis: Correlative studies Pharmacological Study: Correlative studies Talazoparib: Given PO
All Cause Mortality
	Talazoparib
	Affected / at Risk (%)	# Events
Total	38/47 (80.9%)
Serious Adverse Events
	Talazoparib
	Affected / at Risk (%)	# Events
Total	23/47 (48.9%)
Blood and lymphatic system disorders
Anemia	4/47 (8.5%)
Cardiac disorders
Cardiac arrest	1/47 (2.1%)
Palpitations	1/47 (2.1%)
Gastrointestinal disorders
Constipation	1/47 (2.1%)
Dysphagia	1/47 (2.1%)
Esophageal hemorrhage	1/47 (2.1%)
Nausea	3/47 (6.4%)
Vomiting	3/47 (6.4%)
General disorders
Death NOS	2/47 (4.3%)
Fatigue	4/47 (8.5%)
Non-cardiac chest pain	2/47 (4.3%)
Pain	2/47 (4.3%)
Infections and infestations
Lung infection	3/47 (6.4%)
Sepsis	1/47 (2.1%)
Investigations
Platelet count decreased	3/47 (6.4%)
Metabolism and nutrition disorders
Anorexia	1/47 (2.1%)
Dehydration	1/47 (2.1%)
Hyponatremia	2/47 (4.3%)
Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Neoplasms benign, malignant and unspecified - Other	1/47 (2.1%)
Psychiatric disorders
Confusion	1/47 (2.1%)
Respiratory, thoracic and mediastinal disorders
Aspiration	1/47 (2.1%)
Cough	1/47 (2.1%)
Dyspnea	8/47 (17%)
Epistaxis	1/47 (2.1%)
Hypoxia	1/47 (2.1%)
Laryngeal hemorrhage	1/47 (2.1%)
Pleural effusion	1/47 (2.1%)
Pneumonitis	1/47 (2.1%)
Productive cough	1/47 (2.1%)
Resp, thoracic and mediastinal disorders - Other	2/47 (4.3%)
Respiratory failure	3/47 (6.4%)
Vascular disorders
Hypertension	2/47 (4.3%)
Hypotension	2/47 (4.3%)
Other (Not Including Serious) Adverse Events
	Talazoparib
	Affected / at Risk (%)	# Events
Total	47/47 (100%)
Blood and lymphatic system disorders
Anemia	27/47 (57.4%)
Lymph node pain	1/47 (2.1%)
Cardiac disorders
Atrial fibrillation	3/47 (6.4%)
Atrioventricular block first degree	1/47 (2.1%)
Cardiac disorders-Other	2/47 (4.3%)
Sinus tachycardia	2/47 (4.3%)
Endocrine disorders
Hyperthyroidism	2/47 (4.3%)
Eye disorders
Dry eye	2/47 (4.3%)
Flashing lights	1/47 (2.1%)
Gastrointestinal disorders
Abdominal pain	3/47 (6.4%)
Constipation	2/47 (4.3%)
Diarrhea	4/47 (8.5%)
Dry mouth	2/47 (4.3%)
Dyspepsia	1/47 (2.1%)
Dysphagia	3/47 (6.4%)
Flatulence	1/47 (2.1%)
Gastrointestinal disorders-Other	1/47 (2.1%)
Mucositis oral	1/47 (2.1%)
Nausea	14/47 (29.8%)
Oral pain	1/47 (2.1%)
Rectal pain	1/47 (2.1%)
Vomiting	10/47 (21.3%)
General disorders
Chills	2/47 (4.3%)
Edema limbs	4/47 (8.5%)
Fatigue	24/47 (51.1%)
Fever	2/47 (4.3%)
Gait disturbance	1/47 (2.1%)
General disorders and admin site conditions - Other	1/47 (2.1%)
Localized edema	1/47 (2.1%)
Malaise	1/47 (2.1%)
Non-cardiac chest pain	1/47 (2.1%)
Pain	4/47 (8.5%)
Hepatobiliary disorders
Hepatic failure	1/47 (2.1%)
Infections and infestations
Infections and infestations-Other	1/47 (2.1%)
Lung infection	4/47 (8.5%)
Sepsis	1/47 (2.1%)
Upper respiratory infection	2/47 (4.3%)
Wound infection	1/47 (2.1%)
Injury, poisoning and procedural complications
Bruising	1/47 (2.1%)
Fall	1/47 (2.1%)
Investigations
Alanine aminotransferase increased	3/47 (6.4%)
Alkaline phosphatase increased	6/47 (12.8%)
Aspartate aminotransferase increased	5/47 (10.6%)
Blood bilirubin increased	4/47 (8.5%)
Cardiac troponin I increased	1/47 (2.1%)
Cardiac troponin T increased	1/47 (2.1%)
Creatinine increased	3/47 (6.4%)
INR increased	2/47 (4.3%)
Investigations-Other	5/47 (10.6%)
Lymphocyte count decreased	14/47 (29.8%)
Neutrophil count decreased	3/47 (6.4%)
Platelet count decreased	23/47 (48.9%)
Weight gain	1/47 (2.1%)
Weight loss	12/47 (25.5%)
White blood cell decreased	11/47 (23.4%)
Metabolism and nutrition disorders
Anorexia	14/47 (29.8%)
Dehydration	5/47 (10.6%)
Glucose intolerance	2/47 (4.3%)
Hypercalcemia	8/47 (17%)
Hyperglycemia	10/47 (21.3%)
Hyperkalemia	4/47 (8.5%)
Hypoalbuminemia	12/47 (25.5%)
Hypocalcemia	6/47 (12.8%)
Hypoglycemia	2/47 (4.3%)
Hypokalemia	4/47 (8.5%)
Hypomagnesemia	8/47 (17%)
Hyponatremia	13/47 (27.7%)
Hypophosphatemia	6/47 (12.8%)
Metabolism and nutrition disorders - Other, specify	2/47 (4.3%)
Musculoskeletal and connective tissue disorders
Arthralgia	1/47 (2.1%)
Back pain	2/47 (4.3%)
Chest wall pain	1/47 (2.1%)
Flank pain	1/47 (2.1%)
Generalized muscle weakness	6/47 (12.8%)
Musculoskeletal and connective tiss disorder - Other	2/47 (4.3%)
Pain in extremity	4/47 (8.5%)
Nervous system disorders
Amnesia	1/47 (2.1%)
Dizziness	5/47 (10.6%)
Dysgeusia	2/47 (4.3%)
Headache	9/47 (19.1%)
Memory impairment	1/47 (2.1%)
Peripheral sensory neuropathy	2/47 (4.3%)
Somnolence	1/47 (2.1%)
Psychiatric disorders
Anxiety	2/47 (4.3%)
Confusion	1/47 (2.1%)
Delirium	1/47 (2.1%)
Depression	2/47 (4.3%)
Insomnia	2/47 (4.3%)
Renal and urinary disorders
Acute kidney injury	1/47 (2.1%)
Cystitis noninfective	1/47 (2.1%)
Urinary incontinence	1/47 (2.1%)
Urinary retention	1/47 (2.1%)
Urinary tract pain	1/47 (2.1%)
Respiratory, thoracic and mediastinal disorders
Allergic rhinitis	1/47 (2.1%)
Cough	7/47 (14.9%)
Dyspnea	10/47 (21.3%)
Hypoxia	1/47 (2.1%)
Nasal congestion	2/47 (4.3%)
Pleural effusion	1/47 (2.1%)
Pleuritic pain	1/47 (2.1%)
Pneumonitis	2/47 (4.3%)
Productive cough	5/47 (10.6%)
Resp, thoracic and mediastinal disorders - Other	1/47 (2.1%)
Sinus disorder	1/47 (2.1%)
Wheezing	3/47 (6.4%)
Skin and subcutaneous tissue disorders
Alopecia	1/47 (2.1%)
Pruritus	1/47 (2.1%)
Rash maculo-papular	1/47 (2.1%)
Skin and subcutaneous tissue disorders - Other	3/47 (6.4%)
Vascular disorders
Hot flashes	1/47 (2.1%)
Hypertension	3/47 (6.4%)
Hypotension	6/47 (12.8%)
Thromboembolic event	3/47 (6.4%)

Limitations/Caveats

[Not Specified]

More Information

Certain Agreements

Principal Investigators are NOT employed by the organization sponsoring the study.

There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed.