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Atrial Fibrillation and the Risk for Neurological Complications

Sponsor
University Hospital Muenster (Other)
Overall Status
Unknown status
CT.gov ID
NCT00357227
Collaborator
German Federal Ministry of Education and Research (Other)
1,000
Enrollment
1
Location

Study Details

Study Description

Brief Summary

B8: Atrial fibrillation and the risk of neurological complications

Twenty-five thousand acute strokes are caused by atrial fibrillation every year. But even more frequent than symptomatic strokes are silent infarctions of the brain. Silent strokes remain undetected in most cases, but cumulate over time and progressively impair cognition. The impact of atrial fibrillation on subacute brain infarctions is not yet known. Moreover, it has not been elucidated so far how effective different therapeutic strategies in the treatment of atrial fibrillation prevent cognitive impairment. Thus, this study aims at evaluating the influence of different types of atrial fibrillation on silent strokes and the related impairment in cognitive functions. Other risk factors and cardiovascular diseases that are known to provoke the development of strokes will be assessed as well. So, it will be possible to isolate the contribution of atrial fibrillation to silent strokes and related cognitive impairment in segregation to other relevant factors. AF patients and controls will be examined twice in two years in order to evaluate the role of atrial fibrillation and differential therapeutic interventions with regard to the progression of silent strokes and cognitive impairment in a within subject-design.

Condition or Disease Intervention/Treatment Phase

    Study Design

    Study Type:
    Observational
    Observational Model:
    Defined Population
    Time Perspective:
    Prospective
    Official Title:
    Atrial Fibrillation and the Risk for Neurological Complications
    Study Start Date :
    Jan 1, 2004

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      50 Years to 85 Years
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:
      • Clinical diagnosis of permanent, paroxysmal or episodic atrial fibrillation in the past or at present
      Exclusion Criteria:

      • Pacemaker

      • Metal implants

      • History of acute stroke

      • Diagnosis of vascular or degenerative dementia

      • History of brain tumors

      • History of severe brain injury

      • History of psychiatric disorders

      • Pregnancy

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 University Hospital Münster, Dept. of Neurology Münster NRW Germany 48149

      Sponsors and Collaborators

      • University Hospital Muenster
      • German Federal Ministry of Education and Research

      Investigators

      • Principal Investigator: Stefan Knecht, Prof., University Hospital Münster, Department of Neurology

      Study Documents (Full-Text)

      None provided.

      More Information

      Additional Information:

      Publications

      None provided.
      Responsible Party:
      , ,
      ClinicalTrials.gov Identifier:
      NCT00357227
      Other Study ID Numbers:
      • 01 GI 0204
      First Posted:
      Jul 27, 2006
      Last Update Posted:
      Apr 19, 2007
      Last Verified:
      Apr 1, 2007
      Keywords provided by , ,
      Atrial fibrillation
      Stroke
      Vascular Dementia
      Mild Cognitive Impairment
      Additional relevant MeSH terms:
      Atrial Fibrillation

      Study Results

      No Results Posted as of Apr 19, 2007