Clincosm LogoSign in Get a demo

Biomarkers of Atrial Fibrillation Complicated With Stroke Based on Proteomics and Metabolomics

Sponsor
Yue LI (Other)
Overall Status
Recruiting
CT.gov ID
NCT05181787
Collaborator
(none)
200
Enrollment
1
Location
24.3
Anticipated Duration (Months)
8.2
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Thrombus shedding in patients with atrial fibrillation (AF) can lead to cerebral artery embolism. Stroke caused by AF is very dangerous, which not only threatens the life of patients, but also seriously affects the quality of life. This study aims to explore the biomarkers of stroke in patients with AF by integrating proteomics and metabolomics data, and establish the network relationship of stroke in patients with AF, so as to reveal the molecular mechanism of stroke in patients with AF.

Condition or Disease Intervention/Treatment Phase
  • Diagnostic Test: Proteomics
  • Diagnostic Test: Metabolomics

Study Design

Study Type:
Observational [Patient Registry]
Anticipated Enrollment :
200 participants
Observational Model:
Case-Control
Time Perspective:
Prospective
Official Title:
Biomarkers of Atrial Fibrillation Complicated With Stroke Based on Proteomics and Metabolomics
Actual Study Start Date :
Dec 20, 2021
Anticipated Primary Completion Date :
Dec 31, 2023
Anticipated Study Completion Date :
Dec 31, 2023

Arms and Interventions

Arm Intervention/Treatment
AF

Patients with AF

Diagnostic Test: Proteomics
Proteomic data were obtained by LC-MS/MS Analysis-DIA platform.

Diagnostic Test: Metabolomics
Metabolomic data were obtained by UPLC-QTOF/MS platform.
AF and stroke

Patients with AF complicated with stroke

Diagnostic Test: Proteomics
Proteomic data were obtained by LC-MS/MS Analysis-DIA platform.

Diagnostic Test: Metabolomics
Metabolomic data were obtained by UPLC-QTOF/MS platform.

Outcome Measures

Primary Outcome Measures

  1. Biomarkers of atrial fibrillation complicated with stroke based on proteomics and metabolomics [1 day]

    By combining proteomics and metabolomics data, the investigators were able to identify the common pathways involved in AF with stroke.

Secondary Outcome Measures

  1. Quantitative changes of individual metabolites and proteins were calculated and graphed using the KEGG mapping tools. [1 day]

  2. By combining proteomics and metabolomics data, the investigators were able to identify the common pathways involved in AF with stroke. [1 day]

  3. All of the omics data were used to compare proteins/enzymes with metabolic pathways. [1 day]

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years and Older
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
No
Inclusion Criteria:

  1. Age 18 years or above

  2. Admission with atrial fibrillation or clinic visit for atrial fibrillation

  3. Receive routine anticoagulant therapy;

  4. Signing the consent form

Exclusion Criteria:

  1. Pregnant women;

  2. Lactating women;

  3. Severe mitral stenosis;

  4. Severe impairment of liver function;

  5. Severe renal insufficiency;

  6. Thyroid dysfunction requiring treatment.

Contacts and Locations

Locations

Site City State Country Postal Code
1 Yan Harbin Heilongjiang China 150001

Sponsors and Collaborators

  • Yue LI

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Yue LI, Professor, First Affiliated Hospital of Harbin Medical University
ClinicalTrials.gov Identifier:
NCT05181787
Other Study ID Numbers:
  • AF and stroke 1
First Posted:
Jan 6, 2022
Last Update Posted:
Jan 25, 2022
Last Verified:
Jan 1, 2022
Individual Participant Data (IPD) Sharing Statement:
Undecided
Plan to Share IPD:
Undecided
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Keywords provided by Yue LI, Professor, First Affiliated Hospital of Harbin Medical University
Atrial Fibrillation
Stroke
metabolomics
proteomics
Biomarkers
Additional relevant MeSH terms:
Stroke
Atrial Fibrillation

Study Results

No Results Posted as of Jan 25, 2022