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Comparison Of Outcome Of Microneedling With Autologous PRP Vs Microneedling With Topical Insulin In Treatment Of Post Acne Atrophic Scars.

Sponsor
Jinnah Postgraduate Medical Centre (Other)
Overall Status
Completed
CT.gov ID
NCT06002854
Collaborator
(none)
50
Enrollment
1
Location
2
Arms
6
Actual Duration (Months)
8.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Microneedling with topical INSULIN is a simple, effective tool for building body's new collagen layers and thus an alternative to all erosive techniques such as lasers, peels. The skin responds to fine punctures with the release of growth factors. 8 It is a safe procedure that can be performed in the office without complications, with a good cost-benefit because it is economically viable without any effect on patient's daily activities. 9

Condition or Disease Intervention/Treatment Phase
  • Drug: PRP( platelet rich plasma) and Insulin human
 Phase 2

Study Design

Study Type:
Interventional
Actual Enrollment :
50 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
None (Open Label)
Primary Purpose:
Treatment
Official Title:
Comparison Of The Outcome Of Treatment of Microneedling With Autologous Platelet- Rich -Plasma Versus Microneedling With Topical Insulin In The Treatment Of Post Acne Atrophic Scars.
Actual Study Start Date :
Aug 1, 2022
Actual Primary Completion Date :
Dec 1, 2022
Actual Study Completion Date :
Feb 1, 2023

Arms and Interventions

Arm Intervention/Treatment
Experimental: GROUP A Microneedling with PRP(platelete rich plasma)

Drug: PRP( platelet rich plasma) and Insulin human
Microneedling with autologus PRP reduces inflammationin acne scars. Insulin human is a new topical drug which is used nowadays for acne scars as it is more effective in producing collagen formation as well as new blood vessel formation
Experimental: GROUP B Microneedling with topical INSULIN

Drug: PRP( platelet rich plasma) and Insulin human
Microneedling with autologus PRP reduces inflammationin acne scars. Insulin human is a new topical drug which is used nowadays for acne scars as it is more effective in producing collagen formation as well as new blood vessel formation

Outcome Measures

Primary Outcome Measures

  1. Efficacy of Topical Insulin R with microneedling versus Platelets rich plasma in atrophic acne scars [Efficacy will be assesed upto 4 months.]

    Efficacy will be assessed by using Goodman and Baron Qualitative Scar Grading System

Eligibility Criteria

Criteria

Ages Eligible for Study:
20 Years to 50 Years
Sexes Eligible for Study:
All
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:

  • postacne atrophic scars ≥ 2 on Goodman and Baron's acne scar-grading system

  • Either gender.

  • Age 20-50 years.

Exclusion Criteria:

  • lactation and pregnancy

  • skin cancers and infection

  • photosensitivity like SLE ,XP

  • use of RETINOIDS in last 6 months.

Contacts and Locations

Locations

Site City State Country Postal Code
1 JPMC Karachi Sindh Pakistan

Sponsors and Collaborators

  • Jinnah Postgraduate Medical Centre

Investigators

  • Principal Investigator: KHADIJA ASADULLAH, MBBS, JPMC
  • Principal Investigator: FAIZA INAM, FCPS, JPMC
  • Principal Investigator: PARISA SANAWAR, FCPS, JPMC

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Nazia Jabeen, Principal Investigator, Jinnah Postgraduate Medical Centre
ClinicalTrials.gov Identifier:
NCT06002854
Other Study ID Numbers:
  • NO.F.2-81/2022-GENL/252/JPMC
First Posted:
Aug 21, 2023
Last Update Posted:
Aug 21, 2023
Last Verified:
Jun 1, 2023
Studies a U.S. FDA-regulated Drug Product:
No
Studies a U.S. FDA-regulated Device Product:
No
Additional relevant MeSH terms:
Atrophy
Insulin
Insulin, Globin Zinc

Study Results

No Results Posted as of Aug 21, 2023