Effects of Parmigiano Reggiano on Muscle and Inflammatory Response to Eccentric Resistance Training in Older Adults
Study Details
Study Description
Brief Summary
Aging is associated with the loss of muscle mass and function (sarcopenia) and reduced tissue regenerative capacity.
Eccentric exercise (ECC) is a model of RET that can be used with the elderly, due to the ability of the muscle to combine high muscle strength production with low energy cost. ECC contractions are significantly more damaging to the muscles and produce greater muscle strength, for these reasons there is a greater risk of inducing muscle damage before the muscle is able to adapt.
Parmigiano Reggiano (PR) has some peculiar bromatological characteristics. The proteins contained in it, and in particular the potentially bioactive peptide sequences, can rapidly provide the amino acids necessary to promote muscle growth and repair during exercise. Furthermore, PR can be an important source of fatty acids, of which a significant amount of short-chain fatty acids (SCFA) which are known to have important clinical effects on body composition and metabolic health and can have a systemic anti-inflammatory effect.
Therefore, the central hypothesize is that PR consumed while being engaged in a RET can provide more energy substrates and improve muscle recovery, redcue inflammatory markers and improve lipid metabolism. To date, no studies have studied its function on recovery from exercise nor in the elderly.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Parmigiano Reggiano participants will consume 50 g/die of the dietary supplement and undergo to eccentric exercise training 3 times/week |
Dietary Supplement: Parmigiano Reggiano
subjects will receive 50 g/die of the dietary supplement
|
| Active Comparator: Whey Protein participants will consume 20 g/die of the dietary supplement and undergo to eccentric exercise training 3 times/week |
Dietary Supplement: Whey Protein
subjects will receive 20 g/die of the dietary supplement
|
Outcome Measures
Primary Outcome Measures
- Leg lean Mass [Change from baseline to up to 12 weeks]
kg of lean mass measured via DEXA
Secondary Outcome Measures
- inflammatory marker: IL-6 [Change from baseline to up to 12 weeks]
levels of plasma IL-6 (mg/dL)
- cholesterol [Change from baseline to up to 12 weeks]
levels of plasma cholesterol (mg/dL)
Eligibility Criteria
Criteria
Inclusion Criteria:
-
age >60 years
-
BMI >18 and <30 kg/m2
-
stable body weight in the past 3 months
-
valid medical certifacate for practice of physical activity
Exclusion Criteria:
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diabetes or pre-diabetes as for ADA guidelines
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chronic diseases (cardiovascular, liver, respiratory, cancer, etc)
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acute inflammatory status
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regular practice of intense physical activity (>2 sessions/week)
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treatment with steroids in the past 3 months
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regular use of >50g/die of Parmigiano Reggiano
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Nutrition and Exercise Lab, DSB, University of Padova | Padova | Italy | 35131 |
Sponsors and Collaborators
- University of Padova
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- PaRMA.2