ATENC!Ó: Effect of Air Pollution on the Cognitive Function of Adolescents

Sponsor
Barcelona Institute for Global Health (Other)
Overall Status
Completed
CT.gov ID
NCT03762239
Collaborator
Recercaixa (Other), Centre de Recerca per a l'Educació Científica i Matemàtica (CRECIM) (Other), Institute of Environmental Assessment and Water Research (IDAEA-CSIC) (Other), Economics and Bussiness Department, Universtitat Pompeu Fabra (Other)
2,123
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2
6.6
323.1

Study Details

Study Description

Brief Summary

Previous observational studies have reported an association between higher air pollution exposure and lower attention in children. With this project, the investigators aim to confirm this association in adolescents using an experimental design. In addition, the study will assess the relationship between air pollution exposure and individual preferences with respect to risk, time and social considerations. High school students in 3rd grade (ESO, 14-15 years of age) in different high schools in the Barcelona province (Spain) will be invited to participate. For each class in each high school, participating students will be randomly split into two equal-sized groups. Each group will be assigned to a different classroom where they will complete several activities during two hours, including an attention test (Flanker task) and a reduced version of the Global Preferences Survey. One of the classrooms will have an air purifier that will clean the air. The other classroom will have the same device but without the filters, so it will only re-circulate the air without cleaning it. Students will be masked to intervention allocation. The investigators hypothesize that students assigned to the clean air classroom will have better scores in the attention test, and that decision-making will also present differences in the two classrooms.

Condition or Disease Intervention/Treatment Phase
  • Other: Purifying the air with a Pure Airbox device (Zonair 3D)
  • Other: Using a sham air purifier (same device without filters)
N/A

Study Design

Study Type:
Interventional
Actual Enrollment :
2123 participants
Allocation:
Randomized
Intervention Model:
Parallel Assignment
Masking:
Single (Participant)
Primary Purpose:
Prevention
Official Title:
Citizen Science for Analysing the Effect of Air Pollution on the Cognitive Function of Adolescents
Actual Study Start Date :
Nov 23, 2018
Actual Primary Completion Date :
Jun 11, 2019
Actual Study Completion Date :
Jun 11, 2019

Arms and Interventions

Arm Intervention/Treatment
Active Comparator: Purified air

Purifying the air with a Pure Airbox device (Zonair 3D). Use of air purifier (Pure Airbox, Zonair 3D) in the classroom 30 minutes before the participants enter the room and during the 2 hours of the experiment.

Other: Purifying the air with a Pure Airbox device (Zonair 3D)
Purifying the air of the classroom where the experiment is conducted using a Pure Airbox device (Zonair 3D)
Other Names:
  • Air filtering
  • Air cleaning
  • Sham Comparator: Normal air

    Using a sham air purifier (same device without filters). Use of the same air purifier but without filters, so that it only recirculates the air without purifying it. Used for the same time period than the other arm.

    Other: Using a sham air purifier (same device without filters)
    Use the air purifier (Pure Airbox, Zonair 3D) without filters in the classroom where the experiment is conducted
    Other Names:
  • Sham air cleaner
  • Outcome Measures

    Primary Outcome Measures

    1. Response speed consistency throughout the Attention Network Task-Flanker Task (post ANT) [Obtained from a test administered approximately 90 minutes after entering the classroom]

      Calculated as hit reaction time standard error for correct responses (HRT-SE). A higher HRT-SE indicates highly variable reactions related to inattentiveness

    2. Combined risk taking score [Obtained from a test administered approximately 100 minutes after entering the classroom]

      Risk taking = 0.4729985 × "Risk preference score" + 0.5270015 × "Willingness to take risks", that follows the parameters of Falk et al (2018), where the "Risk preference score" is the final node in the risk tree (see the online appendix of Falk et al (2018)), which is a value between 1 and 32, ranked by the level of risk aversion, and the "Willingness to take risks" refers to the answer to the question on one's willingness to take risks.

    3. Combined patience score [Obtained from a test administered approximately 100 minutes after entering the classroom]

      Patience = 0.7115185 × "Time preference score" + 0.2884815 × "Self assessment of patience", that follows the parameters of Falk et al (2018), where the "Time preference score" is the final node in the time tree (see the online appendix of Falk et al (2018)), which is a value between 1 and 32, ranked by the level of patience, and the "Self assessment of patience" refers to the answer to the question on the self-assessment of patience (willingness to give up something today).

    4. Positive reciprocity score [Obtained from a test administered approximately 100 minutes after entering the classroom]

      Positive reciprocity = 0.4847038 × "Willingness to return favor" + 0.5152962 × "Size of gift", that follows the parameters of Falk et al (2018), where "Willingness to return favor" refers to the answer to the question on the willingness to return a favor, and "Size of gift" refers to the answer to the question on the reported size of the gift that would return to a stranger.

    5. Altruism score [Obtained from a test administered approximately 100 minutes after entering the classroom]

      Altruism = 0.6350048 × "Willingness to give to good causes" + 0.3649952 × "Hypothetical donation", that follows the parameters of Falk et al (2018), where "Willingness to give to good causes" refers to the answer to the question on the willingness to give to good causes, and "Hypothetical donation" refers to the answer to the question on the size of the hypothetical donation one would be willing to make.

    6. Trust score [Obtained from a test administered approximately 100 minutes after entering the classroom]

      Answer to the question "I assume that people have only the best intentions".

    Secondary Outcome Measures

    1. Impulsivity (from ANT) [Obtained from a test administered approximately 90 minutes after entering the classroom]

      Number of incorrect responses (responses made in the opposite direction to the direction of the target arrow)

    2. Selective attention (from ANT) [Obtained from a test administered approximately 90 minutes after entering the classroom]

      Number of omission errors (failure to respond)

    3. Alerting score (from ANT) [Obtained from a test administered approximately 90 minutes after entering the classroom]

      Subtracting the median RT for double cue from median RT for the no cue condition (calculations performed after removing the incongruent trials)

    4. Orienting score (from ANT) [Obtained from a test administered approximately 90 minutes after entering the classroom]

      Subtracting the median RT for spatial cue from the RT for central cue (calculations performed after removing the incongruent trials)

    5. Conflict score (executive attention) (from ANT) [Obtained from a test administered approximately 90 minutes after entering the classroom]

      Participant's median RT for each flanker condition (across cue conditions) and subtracted the congruent from the incongruent RTs

    6. Self assessment of how good they are in math [Obtained from a test administered approximately 100 minutes after entering the classroom]

      Answer to the question on how good they are in math.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    13 Years to 16 Years
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    Yes
    Inclusion Criteria:
    • Students in the 3rd ESO course in participating high schools with signed informed consent
    Exclusion Criteria:
    • None

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 ISGlobal Barcelona Spain 08003

    Sponsors and Collaborators

    • Barcelona Institute for Global Health
    • Recercaixa
    • Centre de Recerca per a l'Educació Científica i Matemàtica (CRECIM)
    • Institute of Environmental Assessment and Water Research (IDAEA-CSIC)
    • Economics and Bussiness Department, Universtitat Pompeu Fabra

    Investigators

    • Principal Investigator: Xavier Basagaña, PhD, Barcelona Institute for Global Health

    Study Documents (Full-Text)

    More Information

    Publications

    None provided.
    Responsible Party:
    Barcelona Institute for Global Health
    ClinicalTrials.gov Identifier:
    NCT03762239
    Other Study ID Numbers:
    • PI2030
    First Posted:
    Dec 3, 2018
    Last Update Posted:
    Aug 7, 2019
    Last Verified:
    Aug 1, 2019
    Individual Participant Data (IPD) Sharing Statement:
    Yes
    Plan to Share IPD:
    Yes
    Studies a U.S. FDA-regulated Drug Product:
    No
    Studies a U.S. FDA-regulated Device Product:
    No
    Keywords provided by Barcelona Institute for Global Health

    Study Results

    No Results Posted as of Aug 7, 2019