Therapeutic Intervention Effects of rTMS on Children With Autism Spectrum Disorder
Study Details
Study Description
Brief Summary
Autism spectrum disorder (ASD) is a common and complex neurodevelopmental disorder, which is characterized by impairments of social communication, social reciprocity, as well as restricted and repetitive behaviors (RRB). The unclear pathogenesis of ASD, its increasing prevalence, and its poor clinical diagnosis and treatment effect have caused a serious economic and mental burden on patients and their families. As a new non-invasive neuroelectrophysiological technique, transcranial magnetic stimulation (TMS) has been used more and more in the interventional treatment of autism. The current project aims to explore the influence of TMS on brain plasticity in autism by using TMS for interventional treatment of autism and provide guidelines for the intervention and treatment of autism by evaluating the efficiency of these methods.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Detailed Description
Autism spectrum disorder (ASD) is a common and complex neurodevelopmental disorder, which is characterized by impairments of social communication, social reciprocity, as well as restricted and repetitive behaviors (RRB). The unclear pathogenesis of ASD, its increasing prevalence, and its poor clinical diagnosis and treatment effect have caused a serious economic and mental burden on patients and their families. As a new non-invasive neuroelectrophysiological technique, transcranial magnetic stimulation (TMS) has been used more and more in the interventional treatment of autism. The current project aims to explore the influence of TMS on brain plasticity in autism by using TMS for interventional treatment of autism and provide guidelines for the intervention and treatment of autism by evaluating the efficiency of these methods. Investigators conduct a randomized, double-blind, controlled TMS trial and collect the participants' stool samples and sequence the gut microbiome before the first magnetic resonance imaging(MRI) scan. Besides, investigators collect brain imaging data, eye movement data and clinical scale score before and after TMS trial to explore the changes of TMS treatment on clinical behavior and brain plasticity and provide guidelines for the intervention and treatment of autism.
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: High amplitude repeated transcranial magnetic stimulation Applied high amplitude repeated transcranial magnetic stimulation |
Device: Applied high amplitude repeated transcranial magnetic stimulation
Each mode required 20 stimuli(100%RMT) for 20 minutes each time, 5 times a week
|
| Experimental: Low amplitude repeated transcranial magnetic stimulation Applied low amplitude repeated transcranial magnetic stimulation |
Device: Applied low amplitude repeated transcranial magnetic stimulation
Each mode required 20 stimuli(15%RMT) for 20 minutes each time, 5 times a week
|
| No Intervention: healthy control group No intervention |
Outcome Measures
Primary Outcome Measures
- The gray matter volume of children with autism at baseline and after repeated transcranial magnetic stimulation intervention as assessed by magnetic resonance imaging. [through study completion, an average of 1 year]
Longitudinal study of the gray matter volume will be conducted in children with autism at baseline and after repeated transcranial magnetic stimulation intervention based on structural magnetic resonance image. Longitudinal effect of repeated transcranial magnetic stimulation intervention on brain structure in children with autism will be assessed by Voxel-based morphometry analysis for gray matter volume changes.
Secondary Outcome Measures
- The functional connectivity of whole brain of whole brain in children with autism with repeated transcranial magnetic stimulation intervention as assessed by functional magnetic resonance imaging. [through study completion, an average of 1 year]
Longitudinal study of the functional connectivity will be conducted in children with autism at baseline and after repeated transcranial magnetic stimulation intervention based on resting-state functional magnetic resonance image
Eligibility Criteria
Criteria
Inclusion Criteria:
- Age range from 2 to 8 years old. Clinical DSM-IV diagnosis of autism.
Exclusion Criteria:
- Subjects with other neurodevelopmental diseases Subjects with contraindications to MRI.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | School of Life Science and Technology, University of Electronic Science and Technology | Chengdu | Sichuan | China | 610054 |
Sponsors and Collaborators
- University of Electronic Science and Technology of China
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- UESTC-chenhuafulab-003