The Plasticity of Social Brain Network in Adults With Autism Spectrum Disorder
Study Details
Study Description
Brief Summary
"Social brain" refers to brain regions dedicated to processing social information and enabling us to recognize and evaluate others' mental states. The social brain hypothesis suggests that our brains evolve to navigate complex social systems. The social brain is hypothesized to consist of a distributed network including the posterior superior temporal sulcus (pSTS), the dorsal and ventral medial prefrontal cortices (dmPFC and vmPFC), ACC and posterior cingulate cortex (PCC), the amygdala, the orbital frontal cortex (OFC), and the fusiform gyrus (FG), TPJ, inferior occipital gyrus (IOG), and the insula. Each region serves distinct role while works together to support social processing, including perceiving, interpreting, and generating responses to the intentions, dispositions, and behaviors of others.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
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N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: ASD group autistic adolescents with their caregiver |
Behavioral: PEERS
The Program for the Education and Enrichment of Relational Skills (PEERS®) studies is an evidence-based 16-week group-based social skill training program developed for adolescents and young adults with ASD.
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| Sham Comparator: Control group healthy control without their caregiver |
Behavioral: PEERS
The Program for the Education and Enrichment of Relational Skills (PEERS®) studies is an evidence-based 16-week group-based social skill training program developed for adolescents and young adults with ASD.
|
Outcome Measures
Primary Outcome Measures
- Autism Diagnostic Interview Revised, ADIR [16 weeks]
Interview of the caregivers that covers most developmental and behavioral aspects of ASD. Range from 0 to 8, higher the score, worse the symptom.
- The Autism Diagnostic Observation Schedule, ADOS [16 weeks]
Diagnosing and assess autism. Range from 0 to 8, higher the score, worse the symptom.
- Autism Spectrum Quotient [16 weeks]
50 items, total score range from 0 to 50. Higher the score, worse the symptom
- Social responsiveness scale [16 weeks]
65 items, higher the score, worse the syptom
- Quality of socialization questionnaire [16 weeks]
12 items. Higher the score, better the fruquency and quality of socialization
- Empathy quotient [16 weeks]
higher the score, worse the empathy
Eligibility Criteria
Criteria
Inclusion Criteria:
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age between 18 and 50
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diagnosed with ASD from licensed mental health or medical professional based on DSM5
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have social problems
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motivated to participate in the treatment
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fluent in chinese
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caregiver also fluent in chinese and motivated to participate
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had a full-scale IQ > 70 on WAIS-IV
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scored ≧ 26 on the caregiver-reported Autism Spectrum Quotient (AQ), indicating clinical impairment associated with ASD.
Exclusion Criteria:
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history of major mental illness, such as bipolar affective disorder, schizophrenia, psychosis, or neurological diseases
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visual impairment and/or hearing impairement
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any metal, electronic part that cannot be removed from the body, or being pregnant, which may not be able to use fMRI scan.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | National Taiwan University Hospital | Taipei | Zhongzheng Dist. | Taiwan | 100229 |
Sponsors and Collaborators
- National Taiwan University Hospital
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- 202012163RIND