Diffusion Tensor Imaging in Autism

Sponsor

University of Florida (Other)

Overall Status

Withdrawn

CT.gov ID

NCT00382382

Collaborator

(none)

Enrollment

Location

Arms

Duration (Months)

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Using a new and more detailed approach to diffusion tensor imaging (DTI) recently developed in our lab, the investigators hope to learn more about irregularities in the brain that are related to autism. The investigators are especially interested in brain regions that contribute to repetitive behaviors in children with autism. Repetitive behaviors include stereotyped motor movements (hand-flapping), self-injurious behaviors (head hitting), compulsions (lining up toys), insistence on things staying the same, and difficulty with change. These behaviors often interfere with learning, can disrupt daily functioning, and can lead to other behavioral problems. Two specific aims will be accomplished:

Aim 1: To examine the integrity of white matter pathways in high functioning autistic children. The investigators hypothesize that autism is associated with specific white matter abnormalities in the cerebellum and other motor circuits. Additionally, the investigators expect to confirm and expand on previous reports of cerebral abnormalities by using newly developed DTI methods.

Aim 2: To determine whether there is a relationship between white matter abnormalities and the occurrence of restricted repetitive behaviors in children with autism. The investigators hypothesize that differences in the occurrence and type of restricted repetitive behaviors between autistic individuals are correlated with specific regional white matter abnormalities.

Results from the proposed experiments should contribute to current knowledge of brain abnormalities in autism and their relationship to restricted repetitive behaviors, and may be relevant to understanding the mechanisms underlying motor deficits in this disorder.

Condition or Disease	Intervention/Treatment	Phase
Autistic Disorder	Other: diffusion tensor imaging (DTI)	N/A

Detailed Description

Using a new and more detailed approach to diffusion tensor imaging (DTI) recently developed in our lab, the investigators aim to confirm and expand upon previous findings of white matter abnormalities throughout the brain in individuals with autism. The investigators have chosen to focus particularly on cerebellar and motor pathways in consideration of the prevalence of motor deficits in autism as well as brain structural studies that have indicated cerebellar abnormalities in autistic children. Finally, a proposal to investigate a possible functional association between white matter structure and the expression of restricted repetitive behaviors in autistic children, by correlating measures of white matter integrity with behavioral assessments indicating the severity of various forms of restricted repetitive behaviors. Two specific aims will be accomplished. Aim 1: To examine the integrity of white matter pathways in high functioning autistic children. The hypothesis is that autism is associated with specific white matter abnormalities in the cerebellum and other motor circuits. Additionally, it is expect to confirm and expand on previous reports of cerebral abnormalities by using newly developed DTI methods. Aim 2: To determine whether there is a relationship between white matter abnormalities and the occurrence of restricted repetitive behaviors in children with autism. The hypothesis is that differences in the occurrence and type of restricted repetitive behaviors between autistic individuals are correlated with specific regional white matter abnormalities. Results from the proposed experiments should contribute to current knowledge of brain abnormalities in autism and their relationship to restricted repetitive behaviors, and may be relevant to understanding the mechanisms underlying motor deficits in this disorder.

Study Design

Study Type:

Interventional

Actual Enrollment :

0 participants

Allocation:

Non-Randomized

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Health Services Research

Official Title:

Diffusion Tensor Imaging in Autism

Study Start Date :

Jul 1, 2008

Actual Primary Completion Date :

Jul 1, 2009

Actual Study Completion Date :

Jul 1, 2009

Arms and Interventions

Arm	Intervention/Treatment
Other: Children with Autism A diffusion tensor imaging (DTI) will be done to examine the integrity of the white matter pathways in high functioning austistic children.	Other: diffusion tensor imaging (DTI) Both groups will have a diffusion tensor imaging (DTI) perform.
Other: Healthy Volunteers A diffusion tensor imaging (DTI) will be done to examine the integrity of the white matter pathways in healthy volunteers.	Other: diffusion tensor imaging (DTI) Both groups will have a diffusion tensor imaging (DTI) perform.

Arm

Intervention/Treatment

Other: Children with Autism

A diffusion tensor imaging (DTI) will be done to examine the integrity of the white matter pathways in high functioning austistic children.

Other: diffusion tensor imaging (DTI)

Both groups will have a diffusion tensor imaging (DTI) perform.

Other: Healthy Volunteers

A diffusion tensor imaging (DTI) will be done to examine the integrity of the white matter pathways in healthy volunteers.

Other: diffusion tensor imaging (DTI)

Both groups will have a diffusion tensor imaging (DTI) perform.

Outcome Measures

Primary Outcome Measures

RBS-R scores, including both total and subset scores [once]

Eligibility Criteria

Criteria

Ages Eligible for Study:

8 Years to 12 Years

Sexes Eligible for Study:

Male

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

male, aged 8-12 years of age
clinical diagnoses of autism from a licensed professional for Autism or Asperger's Syndrome
IQ >80
no speech delay
no major sensory or motor deficits

Exclusion Criteria:

known genetic or medical conditions (e.g. Fragile X syndrome, tuberous sclerosis, Turner's syndrome)
currently (within prior 3 months) taking anti-psychotic/dopamine-modulating medications