ESAD: Autobiographical Specificity

Sponsor

Nantes University Hospital (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT05642351

Collaborator

(none)

Enrollment

Location

Anticipated Duration (Months)

2.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Autobiographical memory is diminished in patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia, and research has focused on the hampered ability of patients in retrieving specific memories. However, this study proposes a detailed methodology to provide a qualitative analysis of autobiographical specificity.

Condition or Disease	Intervention/Treatment	Phase
Memory Alzheimer Disease Frontotemporal Dementia	Other: Autobiographical reminder

Detailed Description

Patients with Alzheimer's Disease and those with behavioral variant of frontotemporal dementia will be invited to retrieve autobiographical memories. Memories will be analyzed and categorized into specific, categoric, extended, or semantic autobiographical retrieval.

Study Design

Study Type:

Observational

Anticipated Enrollment :

62 participants

Observational Model:

Case-Only

Time Perspective:

Prospective

Official Title:

Autobiographical Specificity in Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia

Anticipated Study Start Date :

Mar 1, 2023

Anticipated Primary Completion Date :

Feb 28, 2025

Anticipated Study Completion Date :

Feb 28, 2025

Arms and Interventions

Arm	Intervention/Treatment
Alzheimer's Disease recruited according to criteria by National Institute on Aging (McKhann et al., 2011).	Other: Autobiographical reminder The analysis of the specificity of Autobiographical Recall will be done through the following scale, developed for the study: 6 points for a recall involving a single personal event located in space AND time (e.g.,"I remember when my parents took me to the sea for the first time..in 1962..in Dunkerque") 5 points for a recall involving a single personal event located in space OR time ("I remember when my parents first took me to the sea...in 1962") 4 points for a recall involving a single personal event but without spatial/temporal details ("I remember when my parents took me to the sea for the first time") 3 points for a recall involving a general personal event but located in space AND time ("we used to go to Dunkerque in the summer") 2 points for a recall involving a general personal event but located in space OR time ("we used to go to Dunkerque") 1 point for a recall involving a general personal event without spatial/temporal details ("we used to go on vacation")
Behavioral variant of frontotemporal dementia recruited following criteria by Rascovsky et al. (2011)	Other: Autobiographical reminder The analysis of the specificity of Autobiographical Recall will be done through the following scale, developed for the study: 6 points for a recall involving a single personal event located in space AND time (e.g.,"I remember when my parents took me to the sea for the first time..in 1962..in Dunkerque") 5 points for a recall involving a single personal event located in space OR time ("I remember when my parents first took me to the sea...in 1962") 4 points for a recall involving a single personal event but without spatial/temporal details ("I remember when my parents took me to the sea for the first time") 3 points for a recall involving a general personal event but located in space AND time ("we used to go to Dunkerque in the summer") 2 points for a recall involving a general personal event but located in space OR time ("we used to go to Dunkerque") 1 point for a recall involving a general personal event without spatial/temporal details ("we used to go on vacation")

Arm

Intervention/Treatment

Alzheimer's Disease

recruited according to criteria by National Institute on Aging (McKhann et al., 2011).

Other: Autobiographical reminder

The analysis of the specificity of Autobiographical Recall will be done through the following scale, developed for the study: 6 points for a recall involving a single personal event located in space AND time (e.g.,"I remember when my parents took me to the sea for the first time..in 1962..in Dunkerque") 5 points for a recall involving a single personal event located in space OR time ("I remember when my parents first took me to the sea...in 1962") 4 points for a recall involving a single personal event but without spatial/temporal details ("I remember when my parents took me to the sea for the first time") 3 points for a recall involving a general personal event but located in space AND time ("we used to go to Dunkerque in the summer") 2 points for a recall involving a general personal event but located in space OR time ("we used to go to Dunkerque") 1 point for a recall involving a general personal event without spatial/temporal details ("we used to go on vacation")

Behavioral variant of frontotemporal dementia

recruited following criteria by Rascovsky et al. (2011)

Other: Autobiographical reminder

Outcome Measures

Primary Outcome Measures

Autobiographical specificity [40 minutes]
We will apply the method by Raes et al. (2007) to assess whether each retrieved event refers to a: specific event, categorical event, extended event, or semantic event

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Alzheimer' disease or avioral variant of frontotemporal dementia
No opposition from the patient to be included in the study
For Alzheimer's patients: a score of more than 24 out of 30 on the Mini Mental State Examination (McKhann et al., 1984)