Treatment of Obstructive Jaundice in Autoimmune Pancreatitis and/or Immunoglobulin G4-related Sclerosing Cholangitis by Corticosteroids
Study Details
Study Description
Brief Summary
This study evaluates corticosteroids in the treatment of obstructive jaundice in autoimmune pancreatitis and/or immunoglobulin G4 (IgG4)-related sclerosing cholangitis in adults. Half of participants will receive corticosteroids alone, while the other half will receive corticosteroids with biliary stent at the beginning.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
N/A |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Active Comparator: Steroids group The patients will be treated with oral corticosteroids (prednisone 0.6mg/kg/d) alone. |
Drug: corticosteroids
prednisone 0.6mg/kg/d
|
Active Comparator: Stent group The patients will be treated with oral corticosteroids and biliary stent. |
Drug: corticosteroids
prednisone 0.6mg/kg/d
Procedure: biliary stent
placement of biliary stent during endoscopic retrograde cholangiopancreatography (ERCP)
|
Outcome Measures
Primary Outcome Measures
- Clinical remission rate of obstructive jaundice [Day 60]
Eligibility Criteria
Criteria
Inclusion Criteria:
-
adults greater than 18 years-old;
-
autoimmune pancreatitis and/or IgG4-related sclerosing cholangitis;
-
obstructive jaundice
Exclusion Criteria:
-
malignancies; active infections;
-
pregnancy or breast feeding;
-
standard contraindications to ERCP;
-
unwillingness or inability to consent for the study
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Peking Union Medical College Hospital | Beijing | Beijing | China | 100730 |
Sponsors and Collaborators
- Peking Union Medical College Hospital
Investigators
- Principal Investigator: Aiming Yang, M.D., Peking Union Medical College Hospital
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- ZS-844