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Acute Caffeine Effects on Cardiac Autonomic and Cardiorespiratory Parameters Responses After Aerobic Exercise

Sponsor
Universidade Estadual Paulista Júlio de Mesquita Filho (Other)
Overall Status
Unknown status
CT.gov ID
NCT02917889
Collaborator
(none)
35
Enrollment
1
Location
2
Arms

Study Details

Study Description

Brief Summary

Check the acute influence of caffeine on the autonomic modulation and cardiorespiratory parameters after aerobic exercise. Hypothesized that caffeine can promote a slower recovery of the cardiorespiratory parameters and the SNA recovery after aerobic exercise.

Condition or Disease Intervention/Treatment Phase
  • Drug: Caffeine
  • Drug: Placebo
  • Other: Cardiopulmonary test
  • Other: Treadmill aerobic exercise
 N/A

Detailed Description

The experimental procedure is divided into three phases, all performed on a treadmill, with a minimum interval of 48 hours between them, in order to allow adequate recovery of the participants. Before the start of the first stage of the experimental protocol or control anthropometric measurements will be carried out, body weight by a digital scale (Plenna, TIN 00139 MAXIMA, Brazil)) and then, using a stadiometer (Plenna, TIN 00139 MAXIMA, Brazil)). The protocols are:

  1. Maximum stress test protocol: assessment of the maximum oxygen consumption (VO2max) on a treadmill (Inbrasport / Millennium), using the Bruce protocol.

  2. Control Protocol (PC): at this stage the volunteer will ingest compressed form of placebo similar to Protocol III and remained at rest after 15 minutes in the supine position, followed by 30 minutes of aerobic exercise on a treadmill, 5 minutes with speed 6.0 km / h followed by 25 minutes with 60% of VO2max and the final 60 minutes lying recovery.

  3. Experimental protocol (PE): In this stage, the volunteer had performed activities similar to the PC, but will make the tablet intake consists of 300mg of caffeine, a value that is within the maximum daily amount allowed under the FDA.

Study Design

Study Type:
Interventional
Actual Enrollment :
35 participants
Allocation:
Randomized
Intervention Model:
Crossover Assignment
Masking:
Single (Participant)
Official Title:
Acute Caffeine Effects on Cardiac Autonomic and Cardiorespiratory Parameters Responses After Aerobic Exercise
Study Start Date :
Feb 1, 2015
Actual Primary Completion Date :
Aug 1, 2016

Arms and Interventions

Arm Intervention/Treatment
Experimental: Caffeine protocol

300 mg in pills

Drug: Caffeine
Volunteers will consume 300 mg of caffeine in pills fifteen minutes before treadmill aerobic exercise.

Other: Cardiopulmonary test
assessment of the maximum oxygen consumption (VO2max) on a treadmill (Inbrasport / Millennium), using Buce protocol. .

Other: Treadmill aerobic exercise
30 mim of aerobic exercise (5 minutes at speed of 5.0 km/h for warming-up followed by 25 minutes at 60% of VO2max ).
Experimental: Placebo protocol

300 mg in pills

Drug: Placebo
Volunteers will consume 300 mg of placebo in pills fifteen minutes before treadmill aerobic exercise.

Other: Cardiopulmonary test
assessment of the maximum oxygen consumption (VO2max) on a treadmill (Inbrasport / Millennium), using Buce protocol. .

Other: Treadmill aerobic exercise
30 mim of aerobic exercise (5 minutes at speed of 5.0 km/h for warming-up followed by 25 minutes at 60% of VO2max ).

Outcome Measures

Primary Outcome Measures

  1. Caffeine effects on heart rate variability (based on frequency, time domain and Chaos) [up to 1 year]

  2. Blood pressure (mmHg) [up to 1 year]

    Caffeine effects blood pressure recovery following aerobic exercise

  3. Heart rate (beats per minute) [up to 1 year]

    Caffeine effects heart rate recovery following aerobic exercise

  4. Respiratory rate (per minute) [up to 1 year]

    Caffeine effects arespiratory rate recovery following aerobic exercise

  5. Oxygen saturation pulse (oximeter-SpO2) [up to 1 year]

    Caffeine effects SpO2 recovery following aerobic exercise

Eligibility Criteria

Criteria

Ages Eligible for Study:
18 Years to 30 Years
Sexes Eligible for Study:
Male
Accepts Healthy Volunteers:
Yes
Inclusion Criteria:
  • healthy men.
Exclusion Criteria:

  • cardiovascular, orthopedic, respiratory and neurological disorders reported or other pathological conditions that prevent the subject to perform the protocols;

  • smokers, alcoholics, or who use drugs that influence the activity of the heart.

Contacts and Locations

Locations

Site City State Country Postal Code
1 Universidade Estadual Paulista Presidente Prudente São Paulo Brazil 19060-900

Sponsors and Collaborators

  • Universidade Estadual Paulista Júlio de Mesquita Filho

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.
Responsible Party:
Luana Almeida Gonzaga, Principal Investigator, Universidade Estadual Paulista Júlio de Mesquita Filho
ClinicalTrials.gov Identifier:
NCT02917889
Other Study ID Numbers:
  • 44888015.8.0000.5406
First Posted:
Sep 28, 2016
Last Update Posted:
Sep 30, 2016
Last Verified:
Sep 1, 2016
Keywords provided by Luana Almeida Gonzaga, Principal Investigator, Universidade Estadual Paulista Júlio de Mesquita Filho
Caffeine
Autonomic Nervous System
Recovery
Aerobic exercise
Additional relevant MeSH terms:
Caffeine

Study Results

No Results Posted as of Sep 30, 2016