C-VIEW: A Study to Assess the Effects of Certolizumab Pegol on the Reduction of Anterior Uveitis (AU) Flares in Axial Spondyloarthritis Subjects With a Documented History of AU
Study Details
Study Description
Brief Summary
The purpose of the study is to demonstrate the effect of Certolizumab Pegol (CZP) treatment on the reduction of Anterior Uveitis (AU) flares in subjects with active axial Spondyloarthritis (axSpA) and a documented history of AU.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Phase 4 |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: Certolizumab Pegol Subjects will receive a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc every two Weeks |
Drug: Certolizumab Pegol
pharmaceutical form: solution for infusion in prefilled syringe
concentration: 200 mg/mL
route of administration: subcutaneous
Other Names:
|
Outcome Measures
Primary Outcome Measures
- Number of Distinct Episodes of Anterior Uveitis (AU) Flares During the Treatment Period [During the pre-study period and during the Treatment Period up to 96 weeks]
A flare was defined as being a new episode of Anterior Uveitis (AU) that, based on the judgment of an ophthalmologist, required specific treatment. A flare was considered a new episode if a gap of at least 3 months occurred between 2 flares.
Secondary Outcome Measures
- Number of Anterior Uveitis (AU) Flares Per 100 Patient-years in Participants With Active Axial SpondyloArthritis (axSpA) and a History of AU at Week 48 [During the pre-study period and during the Treatment Period up to 48 weeks]
A flare was defined as being a new episode of Anterior Uveitis (AU) that, based on the judgment of an ophthalmologist, required specific treatment. A flare was considered a new episode if a gap of at least 3 months occurred between 2 flares.
- Number of Anterior Uveitis (AU) Flares Per 100 Patient-years in Participants With Active Axial SpondyloArthritis (axSpA) and a History of AU at Week 96 [During the pre-study period and during the Treatment Period up to 96 weeks]
A flare was defined as being a new episode of Anterior Uveitis (AU) that, based on the judgment of an ophthalmologist, required specific treatment. A flare was considered a new episode if a gap of at least 3 months occurred between 2 flares.
- Number of Anterior Uveitis (AU) Flares Per 100 Patient-years in Participants With Active Axial SpondyloArthritis (axSpA) and at Least 1 AU Episode Within 12 Months Prior Baseline at Week 48 [During the pre-study period and during the Treatment Period up to 48 weeks]
A flare was defined as being a new episode of Anterior Uveitis (AU) that, based on the judgment of an ophthalmologist, required specific treatment. A flare was considered a new episode if a gap of at least 3 months occurred between 2 flares.
- Number of Anterior Uveitis (AU) Flares Per 100 Patient-years in Participants With Active Axial SpondyloArthritis (axSpA) and at Least 1 AU Episode Within 12 Months Prior Baseline at Week 96 [During the pre-study period and during the Treatment Period up to 96 weeks]
A flare was defined as being a new episode of Anterior Uveitis (AU) that, based on the judgment of an ophthalmologist, required specific treatment. A flare was considered a new episode if a gap of at least 3 months occurred between 2 flares.
- Change From Baseline in Ankylosing Spondylitis Disease Activity Score (ASDAS) at Week 48 [From Baseline to Week 48]
The ASDAS was calculated as the sum of the following: 0.121 × Back pain (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Question 2 result) 0.058 × Duration of morning stiffness (BASDAI Question 6 result) 0.110 × Patient's Global Assessment of Disease Activity (PtGADA) 0.073 × Peripheral pain/swelling (BASDAI Question 3 result) 0.579 × (natural logarithm (C-Reactive Protein (CRP) [mg/L] + 1)) Back pain, PtGADA, duration of morning stiffness, and peripheral pain/swelling are all assessed on a numerical scale (0 to 10 units). The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. There is a minimum score of 0.636 for the total ASDAS score, but no defined upper score. Based on the formula even in the situation that the CRP is normal, any value below 4 is recorded as 'below the limit of quantification' (BLQ) and a value of BLQ/2=2 was prespecified. This assumption is triggering the lowest possible value of 0.636.
- Change From Baseline in Ankylosing Spondylitis Disease Activity Score (ASDAS) at Week 96 [From Baseline to Week 96]
The ASDAS was calculated as the sum of the following: 0.121 × Back pain (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Question 2 result) 0.058 × Duration of morning stiffness (BASDAI Question 6 result) 0.110 × Patient's Global Assessment of Disease Activity (PtGADA) 0.073 × Peripheral pain/swelling (BASDAI Question 3 result) 0.579 × (natural logarithm (C-Reactive Protein (CRP) [mg/L] + 1)) Back pain, PtGADA, duration of morning stiffness, and peripheral pain/swelling are all assessed on a numerical scale (0 to 10 units). The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. There is a minimum score of 0.636 for the total ASDAS score, but no defined upper score. Based on the formula even in the situation that the CRP is normal, any value below 4 is recorded as 'below the limit of quantification' (BLQ) and a value of BLQ/2=2 was prespecified. This assumption is triggering the lowest possible value of 0.636.
- Change From Baseline in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) at Week 48 [From Baseline to Week 48]
The BASDAI is a validated self-reported instrument which consists of 6 horizontal Numeric Rating Scales (NRSs), each with 10 units to measure the severity of the 5 major symptoms: fatigue, spinal pain, peripheral joint pain and swelling, enthesitis, and morning stiffness (both severity and duration) over the last week. To give each symptom equal weighting, the average of the 2 scores relating to morning stiffness is taken. The resulting 0 to 50 sum score is divided by 5 to give a final BASDAI score between 0 and 10, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) at Week 96 [From Baseline to Week 96]
The BASDAI is a validated self-reported instrument which consists of 6 horizontal Numeric Rating Scales (NRSs), each with 10 units to measure the severity of the 5 major symptoms: fatigue, spinal pain, peripheral joint pain and swelling, enthesitis, and morning stiffness (both severity and duration) over the last week. To give each symptom equal weighting, the average of the 2 scores relating to morning stiffness is taken. The resulting 0 to 50 sum score is divided by 5 to give a final BASDAI score between 0 and 10, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Percentage of Participants Meeting Assessment of SpondyloArthritis International Society 20 % Response Criteria (ASAS20) at Week 48 [Week 48]
The ASAS20 is defined as an improvement of at least 20 % and absolute improvement of at least 1 unit on a 0 to 10 Numeric Rating Scale (NRS) in at least 3 of the 4 following domains and absence of deterioration in the potential remaining domain [deterioration was defined as a relative worsening of at least 20 % and an absolute worsening of at least 1 unit]: Patient's Global Assessment of Disease Activity (PtGADA) Pain assessment (the total spinal pain Numeric Rating Scale score) Function (represented by Bath Ankylosing Spondylitis Functional Index (BASFI)) Inflammation (the mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions 5 and 6 concerning morning stiffness intensity and duration)
- Percentage of Participants Meeting Assessment of SpondyloArthritis International Society 20 % Response Criteria (ASAS20) at Week 96 [Week 96]
The ASAS20 is defined as an improvement of at least 20 % and absolute improvement of at least 1 unit on a 0 to 10 Numeric Rating Scale (NRS) in at least 3 of the 4 following domains and absence of deterioration in the potential remaining domain [deterioration was defined as a relative worsening of at least 20 % and an absolute worsening of at least 1 unit]: Patient's Global Assessment of Disease Activity (PtGADA) Pain assessment (the total spinal pain Numeric Rating Scale score) Function (represented by Bath Ankylosing Spondylitis Functional Index (BASFI)) Inflammation (the mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions 5 and 6 concerning morning stiffness intensity and duration)
- Percentage of Participants Meeting Assessment of SpondyloArthritis International Society 40 % Response Criteria (ASAS40) at Week 48 [Week 48]
The ASAS criteria for 40 % improvement were defined as relative improvements of at least 40 %, and absolute improvement of at least 2 units on a 0 to 10 Numeric Rating Scale (NRS) in at least 3 of the 4 domains below and no worsening at all in the remaining domain: Patient's Global Assessment of Disease Activity (PtGADA) Pain assessment (the total spinal pain Numeric Rating Scale score) Function (represented by Bath Ankylosing Spondylitis Functional Index (BASFI)) Inflammation (the mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions 5 and 6 concerning morning stiffness intensity and duration)
- Percentage of Participants Meeting Assessment of SpondyloArthritis International Society 40 % Response Criteria (ASAS40) at Week 96 [Week 96]
The ASAS criteria for 40 % improvement were defined as relative improvements of at least 40 %, and absolute improvement of at least 2 units on a 0 to 10 Numeric Rating Scale (NRS) in at least 3 of the 4 domains below and no worsening at all in the remaining domain: Patient's Global Assessment of Disease Activity (PtGADA) Pain assessment (the total spinal pain Numeric Rating Scale score) Function (represented by Bath Ankylosing Spondylitis Functional Index (BASFI)) Inflammation (the mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions 5 and 6 concerning morning stiffness intensity and duration)
- Percentage of Participants Meeting Assessment of SpondyloArthritis International Society (ASAS) 5/6 Response at Week 48 [Week 48]
The ASAS 5/6 response is defined as at least 20 % improvement in 5 of 6 domains, including spinal mobility (lateral spinal flexion) and C-Reactive Protein (CRP) as more objective measures. As the BASMI was not collected, and there was no alternative measure of spinal mobility available in the study data, the complete component for spinal mobility was missing. Therefore the ASAS 5/6 response criterion cannot be calculated, and the analysis of the secondary efficacy variable ASAS 5/6 had to be dropped.
- Percentage of Participants Meeting Assessment of SpondyloArthritis International Society (ASAS) 5/6 Response at Week 96 [Week 96]
The ASAS 5/6 response is defined as at least 20 % improvement in 5 of 6 domains, including spinal mobility (lateral spinal flexion) and C-Reactive Protein (CRP) as more objective measures. As the BASMI was not collected, and there was no alternative measure of spinal mobility available in the study data, the complete component for spinal mobility was missing. Therefore the ASAS 5/6 response criterion cannot be calculated, and the analysis of the secondary efficacy variable ASAS 5/6 had to be dropped.
- Percentage of Participants With Assessment of SpondyloArthritis International Society (ASAS) Partial Remission (PR) Response at Week 48 [Week 48]
The ASAS PR response is defined as a score of ≤2 units on a 0 to 10 unit scale in all of the 4 following domains: Patient's Global Assessment of Disease Activity (PtGADA) Pain assessment (the total spinal pain Numeric Rating Scale score) Function (represented by Bath Ankylosing Spondylitis Functional Index (BASFI)) Inflammation (the mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions 5 and 6 concerning morning stiffness intensity and duration)
- Percentage of Participants With Assessment of SpondyloArthritis International Society (ASAS) Partial Remission (PR) Response at Week 96 [Week 96]
The ASAS PR response is defined as a score of ≤2 units on a 0 to 10 unit scale in all of the 4 following domains: Patient's Global Assessment of Disease Activity (PtGADA) Pain assessment (the total spinal pain Numeric Rating Scale score) Function (represented by Bath Ankylosing Spondylitis Functional Index (BASFI)) Inflammation (the mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions 5 and 6 concerning morning stiffness intensity and duration)
- Change From Baseline in Tender Joint Count (44 Joint Count) at Week 48 [From Baseline to Week 48]
The following 44 joints were to be examined for swelling and tenderness by the Investigator, another delegated physician, or an appropriately qualified medical professional: Upper body (4) - bilateral sternoclavicular and acromioclavicular joints Upper extremity (26) - bilateral shoulders, elbows, wrists (includes radiocarpal, carpal, and carpometacarpal bones considered as a single unit), metacarpophalangeals (MCPs) I,II, III, IV, and V, and thumb interphalangeals (IPs), and proximal IPs (PIPs) II, III, IV, and V Lower extremity (14) - bilateral knees, ankles, and metatarsophalangeals (I, II, III, IV, and V) The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline in Tender Joint Count (44 Joint Count) at Week 96 [From Baseline to Week 96]
The following 44 joints were to be examined for swelling and tenderness by the Investigator, another delegated physician, or an appropriately qualified medical professional: Upper body (4) - bilateral sternoclavicular and acromioclavicular joints Upper extremity (26) - bilateral shoulders, elbows, wrists (includes radiocarpal, carpal, and carpometacarpal bones considered as a single unit), metacarpophalangeals (MCPs) I,II, III, IV, and V, and thumb interphalangeals (IPs), and proximal IPs (PIPs) II, III, IV, and V Lower extremity (14) - bilateral knees, ankles, and metatarsophalangeals (I, II, III, IV, and V) The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline in Swollen Joint Count (44 Joint Count) at Week 48 [From Baseline to Week 48]
The following 44 joints were to be examined for swelling and tenderness by the Investigator, another delegated physician, or an appropriately qualified medical professional: Upper body (4) - bilateral sternoclavicular and acromioclavicular joints Upper extremity (26) - bilateral shoulders, elbows, wrists (includes radiocarpal, carpal, and carpometacarpal bones considered as a single unit), metacarpophalangeals (MCPs) I,II, III, IV, and V, and thumb interphalangeals (IPs), and proximal IPs (PIPs) II, III, IV, and V Lower extremity (14) - bilateral knees, ankles, and metatarsophalangeals (I, II, III, IV, and V) The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline in Swollen Joint Count (44 Joint Count) at Week 96 [From Baseline to Week 96]
The following 44 joints were to be examined for swelling and tenderness by the Investigator, another delegated physician, or an appropriately qualified medical professional: Upper body (4) - bilateral sternoclavicular and acromioclavicular joints Upper extremity (26) - bilateral shoulders, elbows, wrists (includes radiocarpal, carpal, and carpometacarpal bones considered as a single unit), metacarpophalangeals (MCPs) I,II, III, IV, and V, and thumb interphalangeals (IPs), and proximal IPs (PIPs) II, III, IV, and V Lower extremity (14) - bilateral knees, ankles, and metatarsophalangeals (I, II, III, IV, and V) The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline in Physician's Global Assessment of Disease Activity (PhGADA) at Week 48 [From Baseline to Week 48]
The Investigator assessed the overall status of the participant with respect to the axSpA signs and symptoms and the functional capacity of the participant using a Visual Analog Scale (VAS) where 0 is "very good, asymptomatic and no limitation of normal activities" and 100 is "very poor, very severe symptoms that are intolerable, and the inability to carry out all normal activities." This assessment by the Investigator should be made without any knowledge of the Patient's Global Assessment of Disease Activity (PtGADA). Total score ranges from 0 to 100, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline in Physician's Global Assessment of Disease Activity (PhGADA) at Week 96 [From Baseline to Week 96]
The Investigator assessed the overall status of the participant with respect to the axSpA signs and symptoms and the functional capacity of the participant using a Visual Analog Scale (VAS) where 0 is "very good, asymptomatic and no limitation of normal activities" and 100 is "very poor, very severe symptoms that are intolerable, and the inability to carry out all normal activities." This assessment by the Investigator should be made without any knowledge of the Patient's Global Assessment of Disease Activity (PtGADA). Total score ranges from 0 to 100, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline in Patient's Global Assessment of Disease Activity (PtGADA) at Week 48 [From Baseline to Week 48]
For the PtGADA questionnaire, participants scored their global assessment of their disease activity in response to the question "How active was your spondylitis on average during the last week?" using a Numeric Rating Scale (NRS) where 0 was "not active" and 10 was "very active". Total score ranges from 0 to 10, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline in Patient's Global Assessment of Disease Activity (PtGADA) at Week 96 [From Baseline to Week 96]
For the PtGADA questionnaire, participants scored their global assessment of their disease activity in response to the question "How active was your spondylitis on average during the last week?" using a Numeric Rating Scale (NRS) where 0 was "not active" and 10 was "very active". Total score ranges from 0 to 10, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline in Total Spinal Pain at Week 48 Assessed by Numerical Rating Scale (NRS) [From Baseline to Week 48]
The total spinal pain was assessed with the question 'How much pain of your spine due to spondylitis do you have?' using a Numeric Rating Scale (NRS) where 0 was 'No pain' and 10 was 'Most severe pain'. Usually, a 10 % difference (ie, a 1 point difference on a Numeric Rating Scale (NRS) ranging from 0 to 10) is considered the minimal clinically important difference used to interpret scores (Dworkin et al, 2008). Total score ranges from 0 to 10, with lower scores indicating a worse outcome. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline in Total Spinal Pain at Week 96 Assessed by Numerical Rating Scale (NRS) [From Baseline to Week 96]
The total spinal pain was assessed with the question 'How much pain of your spine due to spondylitis do you have?' using a Numeric Rating Scale (NRS) where 0 was 'No pain' and 10 was 'Most severe pain'. Usually, a 10 % difference (ie, a 1 point difference on a Numeric Rating Scale (NRS) ranging from 0 to 10) is considered the minimal clinically important difference used to interpret scores (Dworkin et al, 2008). Total score ranges from 0 to 10, with lower scores indicating a worse outcome. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline to Week 48 in the Bath Ankylosing Spondylitis Functional Index (BASFI) [From Baseline to Week 48]
The BASFI is a validated disease-specific instrument for assessing physical function (van Tubergen et al, 2015; Calin et al, 1994; van der Heijde et al, 2005). The BASFI comprises 10 items relating to the past week. The Numeric Rating Scale (NRS) version was used for the answering options of each item on a scale of 0 ("Easy") to 10 ("Impossible") (van Tubergen et al, 2002). The BASFI score is the mean of the 10 items such that the total score ranges from 0 to 10, with lower scores indicating better physical function. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline to Week 96 in the Bath Ankylosing Spondylitis Functional Index (BASFI) [From Baseline to Week 96]
The BASFI is a validated disease-specific instrument for assessing physical function (van Tubergen et al, 2015; Calin et al, 1994; van der Heijde et al, 2005). The BASFI comprises 10 items relating to the past week. The Numeric Rating Scale (NRS) version was used for the answering options of each item on a scale of 0 ("Easy") to 10 ("Impossible") (van Tubergen et al, 2002). The BASFI score is the mean of the 10 items such that the total score ranges from 0 to 10, with lower scores indicating better physical function. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline to Week 48 in Inflammation Assessed by the Mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Questions 5 and 6 Concerning Morning Stiffness and Duration [From Baseline to Week 48]
The BASDAI is a validated self-reported instrument which consists of six 10-unit horizontal Numeric Rating Scales (NRS) to measure severity of fatigue, spinal and peripheral joint pain and swelling, enthesitis, and morning stiffness (both severity and duration for each disease activity, respectively) over the last week. The mean of the 2 BASDAI questions related to morning stiffness (questions 5 and 6) ranged from 0 to 10, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Change From Baseline to Week 96 in Inflammation Assessed by the Mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Questions 5 and 6 Concerning Morning Stiffness and Duration [From Baseline to Week 96]
The BASDAI is a validated self-reported instrument which consists of six 10-unit horizontal Numeric Rating Scales (NRS) to measure severity of fatigue, spinal and peripheral joint pain and swelling, enthesitis, and morning stiffness (both severity and duration for each disease activity, respectively) over the last week. The mean of the 2 BASDAI questions related to morning stiffness (questions 5 and 6) ranged from 0 to 10, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening.
- Percentage of Participants Reporting at Least One Treatment-Emergent Adverse Events (TEAEs) During the Study [From Baseline up to the Safety Follow-up Visit (up to Week 104)]
An adverse event (AE) is any untoward medical occurrence in a participant or clinical investigation subject administered a pharmaceutical product that does not necessarily have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign, symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not related to the medicinal (investigational) product.
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Subjects must have a documented diagnosis of adult-onset axial Spondyloarthritis (axSpA) with at least 3 months' symptom duration and meet the Assessment of SpondyloArthritis International Society (ASAS) criteria
-
Subjects must have active disease at Screening as defined by
-
Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score >= 4
-
Spinal pain >= 4 on a 0 to 10 Numerical Rating Scale (NRS; from BASDAI item 2)
-
Nonradiographic (Nr)-axSpA subjects must either have C-reactive protein (CRP) > upper limit of normal (ULN) and /or current evidence of sacroiliitis on magnetic resonance imaging (MRI) (no confirmation by central reading) as defined by ASAS criteria
-
Ankylosing spondylitis (AS) subjects must have evidence of sacroiliitis on x-ray meeting the modified New York (mNY) classification criteria according to the Investigator
-
Subjects must have a documented history of Anterior Uveitis (AU) diagnosed by an ophthalmologist and have at least 2 AU flares in the past, of which at least 1 AU flare was in the last 12 months prior to Baseline
Exclusion Criteria:
-
Other inflammatory arthritis
-
Secondary, noninflammatory condition that, in the Investigator's opinion, is symptomatic enough to interfere with evaluation of the effect of study drug on the subject's primary diagnosis of axial spondyloarthritis (axSpA)
-
Any history of uveitis except for Anterior Uveitis (AU) associated with axSpA
-
Any condition or complicating factor that may interfere with the AU assessment
-
Retisert® or Iluvien® (glucocorticosteroid implant) within 3 years prior to the Baseline Visit or has had complications related to the device
-
Subject has had Retisert or Iluvien (glucocorticosteroid implant) removed within 90 days prior to the Baseline Visit
-
Intraocular or periocular corticosteroids within 90 days prior to the Baseline visit
-
Ozurdex® (dexamethasone implant) within 6 months prior to the Baseline Visit
-
Cyclophosphamide within 30 days prior to the Baseline Visit
-
Intravitreal methotrexate (MTX) within 90 days prior to the Baseline Visit
-
Intravitreal anti-vascular endothelial growth factor (VEGF) therapy
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | As0007 101 | Brno | Czechia | ||
| 2 | As0007 103 | Brno | Czechia | ||
| 3 | As0007 107 | Brno | Czechia | ||
| 4 | As0007 108 | Ostrava | Czechia | ||
| 5 | As0007 109 | Pardubice | Czechia | ||
| 6 | As0007 102 | Praha 2 | Czechia | ||
| 7 | As0007 105 | Praha | Czechia | ||
| 8 | As0007 301 | Freiburg | Germany | ||
| 9 | As0007 302 | München | Germany | ||
| 10 | As0007 303 | Münster | Germany | ||
| 11 | As0007 401 | Amsterdam | Netherlands | ||
| 12 | As0007 506 | Białystok | Poland | ||
| 13 | As0007 510 | Lublin | Poland | ||
| 14 | As0007 509 | Poznań | Poland | ||
| 15 | As0007 511 | Poznań | Poland | ||
| 16 | As0007 502 | Toruń | Poland | ||
| 17 | As0007 501 | Warszawa | Poland | ||
| 18 | As0007 505 | Warszawa | Poland | ||
| 19 | As0007 504 | Wrocław | Poland | ||
| 20 | As0007 507 | Wrocław | Poland | ||
| 21 | As0007 508 | Wrocław | Poland | ||
| 22 | As0007 604 | Barcelona | Spain | ||
| 23 | As0007 601 | Córdoba | Spain |
Sponsors and Collaborators
- UCB Biopharma SRL
Investigators
- Study Director: UCB Cares, 001 844 599 2273 (UCB)
Study Documents (Full-Text)
More Information
Additional Information:
Publications
None provided.- AS0007
- 2016-000343-14
Study Results
Participant Flow
| Recruitment Details | The first participant was enrolled in December 2016 and the last participant was enrolled in December 2017. |
|---|---|
| Pre-assignment Detail | The study included 3 periods as follows: Period 1 (Screening Period) 1 to 5 weeks before Baseline, Period 2 (Treatment Period) Week 0 to Week 96 and Period 3 (FU Period) 10 weeks from the final dose of investigational medicinal product (IMP) received (Week 104). Participant Flow refers to the Safety Set. |
| Arm/Group Title | Certolizumab Pegol |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 milligrams (mg) subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc every 2 weeks (Q2W) (starting at Week 6 until Week 94). |
| Period Title: Overall Study | |
| STARTED | 89 |
| COMPLETED | 83 |
| NOT COMPLETED | 6 |
Baseline Characteristics
| Arm/Group Title | Certolizumab Pegol |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 milligrams (mg) subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc every 2 weeks (Q2W) (starting at Week 6 until Week 94). |
| Overall Participants | 89 |
| Age (Count of Participants) | |
| <=18 years |
0
0%
|
| Between 18 and 65 years |
84
94.4%
|
| >=65 years |
5
5.6%
|
| Age (years) [Mean (Standard Deviation) ] | |
| Mean (Standard Deviation) [years] |
46.52
(11.24)
|
| Sex: Female, Male (Count of Participants) | |
| Female |
33
37.1%
|
| Male |
56
62.9%
|
| Race/Ethnicity, Customized (Count of Participants) | |
| White |
87
97.8%
|
| Other or Mixed |
2
2.2%
|
Outcome Measures
| Title | Number of Distinct Episodes of Anterior Uveitis (AU) Flares During the Treatment Period |
|---|---|
| Description | A flare was defined as being a new episode of Anterior Uveitis (AU) that, based on the judgment of an ophthalmologist, required specific treatment. A flare was considered a new episode if a gap of at least 3 months occurred between 2 flares. |
| Time Frame | During the pre-study period and during the Treatment Period up to 96 weeks |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Full Analysis Set (FAS) consisted of all study participants in the Safety Set (SS) with nonmissing Baseline values for the primary efficacy variable (AU flare incidence data from the prestudy period). |
| Arm/Group Title | Certolizumab Pegol (FAS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 89 |
| Pre-study Historical |
1.9
(0.9)
|
| On-study CZP |
0.3
(0.7)
|
Statistical Analysis 1
| Statistical Analysis Overview | Comparison Group Selection | Certolizumab Pegol (FAS) |
|---|---|---|
| Comments | The Poisson regression allowed for a comparison of event rates adjusting for differences in time between prestudy/on-study periods. Event rates were based on a Poisson model with generalized estimating equations and a log-link, including an offset term for time interval length, and with period and disease duration of axSpA (<2 years/≥2 years) as covariates. A repeated statement was included for participants and assumed an exchangeable correlation structure between prestudy and on-study flares. | |
| Type of Statistical Test | Other | |
| Comments | ||
| Statistical Test of Hypothesis | p-Value | <0.001 |
| Comments | ||
| Method | Poisson regression | |
| Comments | ||
| Method of Estimation | Estimation Parameter | Rate ratio |
| Estimated Value | 0.180 | |
| Confidence Interval |
(2-Sided) 95% 0.116 to 0.281 |
|
| Parameter Dispersion |
Type: Value: |
|
| Estimation Comments | ||
| Title | Number of Anterior Uveitis (AU) Flares Per 100 Patient-years in Participants With Active Axial SpondyloArthritis (axSpA) and a History of AU at Week 48 |
|---|---|
| Description | A flare was defined as being a new episode of Anterior Uveitis (AU) that, based on the judgment of an ophthalmologist, required specific treatment. A flare was considered a new episode if a gap of at least 3 months occurred between 2 flares. |
| Time Frame | During the pre-study period and during the Treatment Period up to 48 weeks |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Full Analysis Set (FAS) consisted of all study participants in the Safety Set (SS) with nonmissing Baseline values for the primary efficacy variable (AU flare incidence data from the prestudy period). |
| Arm/Group Title | Certolizumab Pegol (FAS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 89 |
| Pre-study Historical |
132.72
|
| On-study CZP |
18.56
|
| Title | Number of Anterior Uveitis (AU) Flares Per 100 Patient-years in Participants With Active Axial SpondyloArthritis (axSpA) and a History of AU at Week 96 |
|---|---|
| Description | A flare was defined as being a new episode of Anterior Uveitis (AU) that, based on the judgment of an ophthalmologist, required specific treatment. A flare was considered a new episode if a gap of at least 3 months occurred between 2 flares. |
| Time Frame | During the pre-study period and during the Treatment Period up to 96 weeks |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Full Analysis Set (FAS) consisted of all study participants in the Safety Set (SS) with nonmissing Baseline values for the primary efficacy variable (AU flare incidence data from the prestudy period). |
| Arm/Group Title | Certolizumab Pegol (FAS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 89 |
| Pre-study Historical |
97.51
|
| On-study CZP |
17.67
|
| Title | Number of Anterior Uveitis (AU) Flares Per 100 Patient-years in Participants With Active Axial SpondyloArthritis (axSpA) and at Least 1 AU Episode Within 12 Months Prior Baseline at Week 48 |
|---|---|
| Description | A flare was defined as being a new episode of Anterior Uveitis (AU) that, based on the judgment of an ophthalmologist, required specific treatment. A flare was considered a new episode if a gap of at least 3 months occurred between 2 flares. |
| Time Frame | During the pre-study period and during the Treatment Period up to 48 weeks |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Full Analysis Set (FAS) consisted of all study participants in the Safety Set (SS) with nonmissing Baseline values for the primary efficacy variable (AU flare incidence data from the prestudy period). |
| Arm/Group Title | Certolizumab Pegol (FAS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 89 |
| Pre-study Historical |
132.72
|
| On-study CZP |
18.56
|
| Title | Number of Anterior Uveitis (AU) Flares Per 100 Patient-years in Participants With Active Axial SpondyloArthritis (axSpA) and at Least 1 AU Episode Within 12 Months Prior Baseline at Week 96 |
|---|---|
| Description | A flare was defined as being a new episode of Anterior Uveitis (AU) that, based on the judgment of an ophthalmologist, required specific treatment. A flare was considered a new episode if a gap of at least 3 months occurred between 2 flares. |
| Time Frame | During the pre-study period and during the Treatment Period up to 96 weeks |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Full Analysis Set (FAS) consisted of all study participants in the Safety Set (SS) with nonmissing Baseline values for the primary efficacy variable (AU flare incidence data from the prestudy period). |
| Arm/Group Title | Certolizumab Pegol (FAS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 89 |
| Pre-study Historical |
97.51
|
| On-study CZP |
17.67
|
| Title | Change From Baseline in Ankylosing Spondylitis Disease Activity Score (ASDAS) at Week 48 |
|---|---|
| Description | The ASDAS was calculated as the sum of the following: 0.121 × Back pain (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Question 2 result) 0.058 × Duration of morning stiffness (BASDAI Question 6 result) 0.110 × Patient's Global Assessment of Disease Activity (PtGADA) 0.073 × Peripheral pain/swelling (BASDAI Question 3 result) 0.579 × (natural logarithm (C-Reactive Protein (CRP) [mg/L] + 1)) Back pain, PtGADA, duration of morning stiffness, and peripheral pain/swelling are all assessed on a numerical scale (0 to 10 units). The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. There is a minimum score of 0.636 for the total ASDAS score, but no defined upper score. Based on the formula even in the situation that the CRP is normal, any value below 4 is recorded as 'below the limit of quantification' (BLQ) and a value of BLQ/2=2 was prespecified. This assumption is triggering the lowest possible value of 0.636. |
| Time Frame | From Baseline to Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set (ES) who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing ASDAS at Week 48. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 86 |
| Mean (Standard Deviation) [scores on a scale] |
-1.55
(1.03)
|
| Title | Change From Baseline in Ankylosing Spondylitis Disease Activity Score (ASDAS) at Week 96 |
|---|---|
| Description | The ASDAS was calculated as the sum of the following: 0.121 × Back pain (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Question 2 result) 0.058 × Duration of morning stiffness (BASDAI Question 6 result) 0.110 × Patient's Global Assessment of Disease Activity (PtGADA) 0.073 × Peripheral pain/swelling (BASDAI Question 3 result) 0.579 × (natural logarithm (C-Reactive Protein (CRP) [mg/L] + 1)) Back pain, PtGADA, duration of morning stiffness, and peripheral pain/swelling are all assessed on a numerical scale (0 to 10 units). The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. There is a minimum score of 0.636 for the total ASDAS score, but no defined upper score. Based on the formula even in the situation that the CRP is normal, any value below 4 is recorded as 'below the limit of quantification' (BLQ) and a value of BLQ/2=2 was prespecified. This assumption is triggering the lowest possible value of 0.636. |
| Time Frame | From Baseline to Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing ASDAS at Week 96. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 82 |
| Mean (Standard Deviation) [scores on a scale] |
-1.61
(1.08)
|
| Title | Change From Baseline in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) at Week 48 |
|---|---|
| Description | The BASDAI is a validated self-reported instrument which consists of 6 horizontal Numeric Rating Scales (NRSs), each with 10 units to measure the severity of the 5 major symptoms: fatigue, spinal pain, peripheral joint pain and swelling, enthesitis, and morning stiffness (both severity and duration) over the last week. To give each symptom equal weighting, the average of the 2 scores relating to morning stiffness is taken. The resulting 0 to 50 sum score is divided by 5 to give a final BASDAI score between 0 and 10, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing BASDAI at Week 48. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 86 |
| Mean (Standard Deviation) [scores on a scale] |
-3.2
(2.3)
|
| Title | Change From Baseline in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) at Week 96 |
|---|---|
| Description | The BASDAI is a validated self-reported instrument which consists of 6 horizontal Numeric Rating Scales (NRSs), each with 10 units to measure the severity of the 5 major symptoms: fatigue, spinal pain, peripheral joint pain and swelling, enthesitis, and morning stiffness (both severity and duration) over the last week. To give each symptom equal weighting, the average of the 2 scores relating to morning stiffness is taken. The resulting 0 to 50 sum score is divided by 5 to give a final BASDAI score between 0 and 10, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing BASDAI at Week 96. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 82 |
| Mean (Standard Deviation) [scores on a scale] |
-3.4
(2.2)
|
| Title | Percentage of Participants Meeting Assessment of SpondyloArthritis International Society 20 % Response Criteria (ASAS20) at Week 48 |
|---|---|
| Description | The ASAS20 is defined as an improvement of at least 20 % and absolute improvement of at least 1 unit on a 0 to 10 Numeric Rating Scale (NRS) in at least 3 of the 4 following domains and absence of deterioration in the potential remaining domain [deterioration was defined as a relative worsening of at least 20 % and an absolute worsening of at least 1 unit]: Patient's Global Assessment of Disease Activity (PtGADA) Pain assessment (the total spinal pain Numeric Rating Scale score) Function (represented by Bath Ankylosing Spondylitis Functional Index (BASFI)) Inflammation (the mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions 5 and 6 concerning morning stiffness intensity and duration) |
| Time Frame | Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Percentages were based on the number of participants with an assessment at Week 48. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 86 |
| Number [percentage of participants] |
75.6
84.9%
|
| Title | Percentage of Participants Meeting Assessment of SpondyloArthritis International Society 20 % Response Criteria (ASAS20) at Week 96 |
|---|---|
| Description | The ASAS20 is defined as an improvement of at least 20 % and absolute improvement of at least 1 unit on a 0 to 10 Numeric Rating Scale (NRS) in at least 3 of the 4 following domains and absence of deterioration in the potential remaining domain [deterioration was defined as a relative worsening of at least 20 % and an absolute worsening of at least 1 unit]: Patient's Global Assessment of Disease Activity (PtGADA) Pain assessment (the total spinal pain Numeric Rating Scale score) Function (represented by Bath Ankylosing Spondylitis Functional Index (BASFI)) Inflammation (the mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions 5 and 6 concerning morning stiffness intensity and duration) |
| Time Frame | Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Percentages were based on the number of participants with an assessment at Week 96. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 82 |
| Number [percentage of participants] |
75.6
84.9%
|
| Title | Percentage of Participants Meeting Assessment of SpondyloArthritis International Society 40 % Response Criteria (ASAS40) at Week 48 |
|---|---|
| Description | The ASAS criteria for 40 % improvement were defined as relative improvements of at least 40 %, and absolute improvement of at least 2 units on a 0 to 10 Numeric Rating Scale (NRS) in at least 3 of the 4 domains below and no worsening at all in the remaining domain: Patient's Global Assessment of Disease Activity (PtGADA) Pain assessment (the total spinal pain Numeric Rating Scale score) Function (represented by Bath Ankylosing Spondylitis Functional Index (BASFI)) Inflammation (the mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions 5 and 6 concerning morning stiffness intensity and duration) |
| Time Frame | Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Percentages were based on the number of participants with an assessment at Week 48. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 86 |
| Number [percentage of participants] |
53.5
60.1%
|
| Title | Percentage of Participants Meeting Assessment of SpondyloArthritis International Society 40 % Response Criteria (ASAS40) at Week 96 |
|---|---|
| Description | The ASAS criteria for 40 % improvement were defined as relative improvements of at least 40 %, and absolute improvement of at least 2 units on a 0 to 10 Numeric Rating Scale (NRS) in at least 3 of the 4 domains below and no worsening at all in the remaining domain: Patient's Global Assessment of Disease Activity (PtGADA) Pain assessment (the total spinal pain Numeric Rating Scale score) Function (represented by Bath Ankylosing Spondylitis Functional Index (BASFI)) Inflammation (the mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions 5 and 6 concerning morning stiffness intensity and duration) |
| Time Frame | Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Percentages were based on the number of participants with an assessment at Week 96. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 82 |
| Number [percentage of participants] |
58.5
65.7%
|
| Title | Percentage of Participants Meeting Assessment of SpondyloArthritis International Society (ASAS) 5/6 Response at Week 48 |
|---|---|
| Description | The ASAS 5/6 response is defined as at least 20 % improvement in 5 of 6 domains, including spinal mobility (lateral spinal flexion) and C-Reactive Protein (CRP) as more objective measures. As the BASMI was not collected, and there was no alternative measure of spinal mobility available in the study data, the complete component for spinal mobility was missing. Therefore the ASAS 5/6 response criterion cannot be calculated, and the analysis of the secondary efficacy variable ASAS 5/6 had to be dropped. |
| Time Frame | Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| Data not collected from participants in all Arms/Groups. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 0 |
| Title | Percentage of Participants Meeting Assessment of SpondyloArthritis International Society (ASAS) 5/6 Response at Week 96 |
|---|---|
| Description | The ASAS 5/6 response is defined as at least 20 % improvement in 5 of 6 domains, including spinal mobility (lateral spinal flexion) and C-Reactive Protein (CRP) as more objective measures. As the BASMI was not collected, and there was no alternative measure of spinal mobility available in the study data, the complete component for spinal mobility was missing. Therefore the ASAS 5/6 response criterion cannot be calculated, and the analysis of the secondary efficacy variable ASAS 5/6 had to be dropped. |
| Time Frame | Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| Data not collected from participants in all Arms/Groups. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 0 |
| Title | Percentage of Participants With Assessment of SpondyloArthritis International Society (ASAS) Partial Remission (PR) Response at Week 48 |
|---|---|
| Description | The ASAS PR response is defined as a score of ≤2 units on a 0 to 10 unit scale in all of the 4 following domains: Patient's Global Assessment of Disease Activity (PtGADA) Pain assessment (the total spinal pain Numeric Rating Scale score) Function (represented by Bath Ankylosing Spondylitis Functional Index (BASFI)) Inflammation (the mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions 5 and 6 concerning morning stiffness intensity and duration) |
| Time Frame | Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Percentages were based on the number of participants with an assessment at Week 48. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 86 |
| Number [percentage of participants] |
31.4
35.3%
|
| Title | Percentage of Participants With Assessment of SpondyloArthritis International Society (ASAS) Partial Remission (PR) Response at Week 96 |
|---|---|
| Description | The ASAS PR response is defined as a score of ≤2 units on a 0 to 10 unit scale in all of the 4 following domains: Patient's Global Assessment of Disease Activity (PtGADA) Pain assessment (the total spinal pain Numeric Rating Scale score) Function (represented by Bath Ankylosing Spondylitis Functional Index (BASFI)) Inflammation (the mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questions 5 and 6 concerning morning stiffness intensity and duration) |
| Time Frame | Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Percentages were based on the number of participants with an assessment at Week 96. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 82 |
| Number [percentage of participants] |
36.6
41.1%
|
| Title | Change From Baseline in Tender Joint Count (44 Joint Count) at Week 48 |
|---|---|
| Description | The following 44 joints were to be examined for swelling and tenderness by the Investigator, another delegated physician, or an appropriately qualified medical professional: Upper body (4) - bilateral sternoclavicular and acromioclavicular joints Upper extremity (26) - bilateral shoulders, elbows, wrists (includes radiocarpal, carpal, and carpometacarpal bones considered as a single unit), metacarpophalangeals (MCPs) I,II, III, IV, and V, and thumb interphalangeals (IPs), and proximal IPs (PIPs) II, III, IV, and V Lower extremity (14) - bilateral knees, ankles, and metatarsophalangeals (I, II, III, IV, and V) The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with at least one tender joint count at Baseline (N=59) and had a non-missing tender joint count at Week 48 (N=55). |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 55 |
| Mean (Standard Deviation) [tender joints] |
-4.9
(6.7)
|
| Title | Change From Baseline in Tender Joint Count (44 Joint Count) at Week 96 |
|---|---|
| Description | The following 44 joints were to be examined for swelling and tenderness by the Investigator, another delegated physician, or an appropriately qualified medical professional: Upper body (4) - bilateral sternoclavicular and acromioclavicular joints Upper extremity (26) - bilateral shoulders, elbows, wrists (includes radiocarpal, carpal, and carpometacarpal bones considered as a single unit), metacarpophalangeals (MCPs) I,II, III, IV, and V, and thumb interphalangeals (IPs), and proximal IPs (PIPs) II, III, IV, and V Lower extremity (14) - bilateral knees, ankles, and metatarsophalangeals (I, II, III, IV, and V) The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with at least one tender joint count at Baseline (N=59) and had a non-missing tender joint count at Week 96 (N=51). |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 51 |
| Mean (Standard Deviation) [tender joints] |
-4.7
(8.2)
|
| Title | Change From Baseline in Swollen Joint Count (44 Joint Count) at Week 48 |
|---|---|
| Description | The following 44 joints were to be examined for swelling and tenderness by the Investigator, another delegated physician, or an appropriately qualified medical professional: Upper body (4) - bilateral sternoclavicular and acromioclavicular joints Upper extremity (26) - bilateral shoulders, elbows, wrists (includes radiocarpal, carpal, and carpometacarpal bones considered as a single unit), metacarpophalangeals (MCPs) I,II, III, IV, and V, and thumb interphalangeals (IPs), and proximal IPs (PIPs) II, III, IV, and V Lower extremity (14) - bilateral knees, ankles, and metatarsophalangeals (I, II, III, IV, and V) The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with at least one swollen joint count at Baseline (N=33) and had a non-missing swollen joint count at Week 48 (N=32). |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 32 |
| Mean (Standard Deviation) [swollen joints] |
-4.2
(4.8)
|
| Title | Change From Baseline in Swollen Joint Count (44 Joint Count) at Week 96 |
|---|---|
| Description | The following 44 joints were to be examined for swelling and tenderness by the Investigator, another delegated physician, or an appropriately qualified medical professional: Upper body (4) - bilateral sternoclavicular and acromioclavicular joints Upper extremity (26) - bilateral shoulders, elbows, wrists (includes radiocarpal, carpal, and carpometacarpal bones considered as a single unit), metacarpophalangeals (MCPs) I,II, III, IV, and V, and thumb interphalangeals (IPs), and proximal IPs (PIPs) II, III, IV, and V Lower extremity (14) - bilateral knees, ankles, and metatarsophalangeals (I, II, III, IV, and V) The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with at least one swollen joint count at Baseline (N=33) and had a non-missing swollen joint count at Week 96 (N=30). |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 30 |
| Mean (Standard Deviation) [swollen joints] |
-3.9
(5.2)
|
| Title | Change From Baseline in Physician's Global Assessment of Disease Activity (PhGADA) at Week 48 |
|---|---|
| Description | The Investigator assessed the overall status of the participant with respect to the axSpA signs and symptoms and the functional capacity of the participant using a Visual Analog Scale (VAS) where 0 is "very good, asymptomatic and no limitation of normal activities" and 100 is "very poor, very severe symptoms that are intolerable, and the inability to carry out all normal activities." This assessment by the Investigator should be made without any knowledge of the Patient's Global Assessment of Disease Activity (PtGADA). Total score ranges from 0 to 100, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing PhGADA at Week 48. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 86 |
| Mean (Standard Deviation) [scores on a scale] |
-43.8
(21.6)
|
| Title | Change From Baseline in Physician's Global Assessment of Disease Activity (PhGADA) at Week 96 |
|---|---|
| Description | The Investigator assessed the overall status of the participant with respect to the axSpA signs and symptoms and the functional capacity of the participant using a Visual Analog Scale (VAS) where 0 is "very good, asymptomatic and no limitation of normal activities" and 100 is "very poor, very severe symptoms that are intolerable, and the inability to carry out all normal activities." This assessment by the Investigator should be made without any knowledge of the Patient's Global Assessment of Disease Activity (PtGADA). Total score ranges from 0 to 100, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing PhGADA at Week 96. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 82 |
| Mean (Standard Deviation) [scores on a scale] |
-42.5
(27.1)
|
| Title | Change From Baseline in Patient's Global Assessment of Disease Activity (PtGADA) at Week 48 |
|---|---|
| Description | For the PtGADA questionnaire, participants scored their global assessment of their disease activity in response to the question "How active was your spondylitis on average during the last week?" using a Numeric Rating Scale (NRS) where 0 was "not active" and 10 was "very active". Total score ranges from 0 to 10, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing PtGADA at Week 48. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 86 |
| Mean (Standard Deviation) [scores on a scale] |
-3.6
(2.5)
|
| Title | Change From Baseline in Patient's Global Assessment of Disease Activity (PtGADA) at Week 96 |
|---|---|
| Description | For the PtGADA questionnaire, participants scored their global assessment of their disease activity in response to the question "How active was your spondylitis on average during the last week?" using a Numeric Rating Scale (NRS) where 0 was "not active" and 10 was "very active". Total score ranges from 0 to 10, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing PtGADA at Week 96. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 82 |
| Mean (Standard Deviation) [scores on a scale] |
-3.9
(2.7)
|
| Title | Change From Baseline in Total Spinal Pain at Week 48 Assessed by Numerical Rating Scale (NRS) |
|---|---|
| Description | The total spinal pain was assessed with the question 'How much pain of your spine due to spondylitis do you have?' using a Numeric Rating Scale (NRS) where 0 was 'No pain' and 10 was 'Most severe pain'. Usually, a 10 % difference (ie, a 1 point difference on a Numeric Rating Scale (NRS) ranging from 0 to 10) is considered the minimal clinically important difference used to interpret scores (Dworkin et al, 2008). Total score ranges from 0 to 10, with lower scores indicating a worse outcome. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing total spinal pain assessment at Week 48. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 86 |
| Mean (Standard Deviation) [scores on a scale] |
-3.8
(2.5)
|
| Title | Change From Baseline in Total Spinal Pain at Week 96 Assessed by Numerical Rating Scale (NRS) |
|---|---|
| Description | The total spinal pain was assessed with the question 'How much pain of your spine due to spondylitis do you have?' using a Numeric Rating Scale (NRS) where 0 was 'No pain' and 10 was 'Most severe pain'. Usually, a 10 % difference (ie, a 1 point difference on a Numeric Rating Scale (NRS) ranging from 0 to 10) is considered the minimal clinically important difference used to interpret scores (Dworkin et al, 2008). Total score ranges from 0 to 10, with lower scores indicating a worse outcome. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing total spinal pain assessment at Week 96. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 82 |
| Mean (Standard Deviation) [scores on a scale] |
-4.1
(2.6)
|
| Title | Change From Baseline to Week 48 in the Bath Ankylosing Spondylitis Functional Index (BASFI) |
|---|---|
| Description | The BASFI is a validated disease-specific instrument for assessing physical function (van Tubergen et al, 2015; Calin et al, 1994; van der Heijde et al, 2005). The BASFI comprises 10 items relating to the past week. The Numeric Rating Scale (NRS) version was used for the answering options of each item on a scale of 0 ("Easy") to 10 ("Impossible") (van Tubergen et al, 2002). The BASFI score is the mean of the 10 items such that the total score ranges from 0 to 10, with lower scores indicating better physical function. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing BASFI at Week 48. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 86 |
| Mean (Standard Deviation) [scores on a scale] |
-2.23
(2.33)
|
| Title | Change From Baseline to Week 96 in the Bath Ankylosing Spondylitis Functional Index (BASFI) |
|---|---|
| Description | The BASFI is a validated disease-specific instrument for assessing physical function (van Tubergen et al, 2015; Calin et al, 1994; van der Heijde et al, 2005). The BASFI comprises 10 items relating to the past week. The Numeric Rating Scale (NRS) version was used for the answering options of each item on a scale of 0 ("Easy") to 10 ("Impossible") (van Tubergen et al, 2002). The BASFI score is the mean of the 10 items such that the total score ranges from 0 to 10, with lower scores indicating better physical function. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing BASFI at Week 96. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 82 |
| Mean (Standard Deviation) [scores on a scale] |
-2.28
(2.53)
|
| Title | Change From Baseline to Week 48 in Inflammation Assessed by the Mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Questions 5 and 6 Concerning Morning Stiffness and Duration |
|---|---|
| Description | The BASDAI is a validated self-reported instrument which consists of six 10-unit horizontal Numeric Rating Scales (NRS) to measure severity of fatigue, spinal and peripheral joint pain and swelling, enthesitis, and morning stiffness (both severity and duration for each disease activity, respectively) over the last week. The mean of the 2 BASDAI questions related to morning stiffness (questions 5 and 6) ranged from 0 to 10, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 48 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing BASDAI at Week 48. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 86 |
| Mean (Standard Deviation) [scores on a scale] |
-3.7
(2.8)
|
| Title | Change From Baseline to Week 96 in Inflammation Assessed by the Mean of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Questions 5 and 6 Concerning Morning Stiffness and Duration |
|---|---|
| Description | The BASDAI is a validated self-reported instrument which consists of six 10-unit horizontal Numeric Rating Scales (NRS) to measure severity of fatigue, spinal and peripheral joint pain and swelling, enthesitis, and morning stiffness (both severity and duration for each disease activity, respectively) over the last week. The mean of the 2 BASDAI questions related to morning stiffness (questions 5 and 6) ranged from 0 to 10, with lower scores indicating lower disease activity. The change from Baseline is calculated, a negative value indicating improvement and a positive value worsening. |
| Time Frame | From Baseline to Week 96 |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. Number of participants analyzed reflect those with a non-missing BASDAI at Week 96. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 82 |
| Mean (Standard Deviation) [scores on a scale] |
-3.8
(2.7)
|
| Title | Percentage of Participants Reporting at Least One Treatment-Emergent Adverse Events (TEAEs) During the Study |
|---|---|
| Description | An adverse event (AE) is any untoward medical occurrence in a participant or clinical investigation subject administered a pharmaceutical product that does not necessarily have a causal relationship with this treatment. An AE can therefore be any unfavorable and unintended sign, symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not related to the medicinal (investigational) product. |
| Time Frame | From Baseline up to the Safety Follow-up Visit (up to Week 104) |
Outcome Measure Data
| Analysis Population Description |
|---|
| The Safety Set consisted of all study participants in the Enrolled Set who had received at least 1 dose of IMP. |
| Arm/Group Title | Certolizumab Pegol (SS) |
|---|---|
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). |
| Measure Participants | 89 |
| Number [percentage of participants] |
80.9
90.9%
|
Adverse Events
| Time Frame | Treatment emergent adverse events were collected from Baseline to the Safety Follow-up Visit (up to Week 104) | |
|---|---|---|
| Adverse Event Reporting Description | ||
| Arm/Group Title | Certolizumab Pegol (SS) | |
| Arm/Group Description | Participants received a loading dose of Certolizumab Pegol (CZP) 400 mg subcutaneously (sc) administered at Baseline, Week 2, and Week 4 followed by CZP 200 mg sc Q2W (starting at Week 6 until Week 94). | |
All Cause Mortality |
||
| Certolizumab Pegol (SS) | ||
| Affected / at Risk (%) | # Events | |
| Total | 0/89 (0%) | |
Serious Adverse Events |
||
| Certolizumab Pegol (SS) | ||
| Affected / at Risk (%) | # Events | |
| Total | 11/89 (12.4%) | |
| Ear and labyrinth disorders | ||
| Vestibular disorder | 2/89 (2.2%) | 2 |
| Eye disorders | ||
| Uveitis | 1/89 (1.1%) | 2 |
| Gastrointestinal disorders | ||
| Anal polyp | 1/89 (1.1%) | 1 |
| General disorders | ||
| Incarcerated hernia | 1/89 (1.1%) | 1 |
| Hepatobiliary disorders | ||
| Cholelithiasis | 1/89 (1.1%) | 1 |
| Immune system disorders | ||
| Sarcoidosis | 1/89 (1.1%) | 1 |
| Infections and infestations | ||
| Pneumonia haemophilus | 1/89 (1.1%) | 1 |
| Pneumonia | 1/89 (1.1%) | 1 |
| Musculoskeletal and connective tissue disorders | ||
| Tenosynovitis | 1/89 (1.1%) | 1 |
| Neoplasms benign, malignant and unspecified (incl cysts and polyps) | ||
| Breast cancer | 1/89 (1.1%) | 1 |
| Haemangioma | 1/89 (1.1%) | 1 |
| Prostate cancer | 2/89 (2.2%) | 2 |
| Pregnancy, puerperium and perinatal conditions | ||
| Pregnancy | 1/89 (1.1%) | 1 |
Other (Not Including Serious) Adverse Events |
||
| Certolizumab Pegol (SS) | ||
| Affected / at Risk (%) | # Events | |
| Total | 51/89 (57.3%) | |
| Eye disorders | ||
| Uveitis | 14/89 (15.7%) | 23 |
| Iridocyclitis | 8/89 (9%) | 12 |
| Infections and infestations | ||
| Nasopharyngitis | 15/89 (16.9%) | 22 |
| Upper respiratory tract infection | 12/89 (13.5%) | 15 |
| Influenza | 6/89 (6.7%) | 9 |
| Rhinitis | 6/89 (6.7%) | 9 |
| Investigations | ||
| Alanine aminotransferase increased | 5/89 (5.6%) | 5 |
| Musculoskeletal and connective tissue disorders | ||
| Arthralgia | 6/89 (6.7%) | 7 |
| Respiratory, thoracic and mediastinal disorders | ||
| Oropharyngeal pain | 5/89 (5.6%) | 5 |
Limitations/Caveats
More Information
Certain Agreements
Principal Investigators are NOT employed by the organization sponsoring the study.
The only disclosure restriction on the PI is that the sponsor can review results communications prior to public release and can embargo communications regarding trial results for a period that is more than 60 days but less than or equal to 180 days. The sponsor cannot require changes to the communication and cannot extend the embargo.
Results Point of Contact
| Name/Title | UCB |
|---|---|
| Organization | Cares |
| Phone | +1844 599 ext 2273 |
| UCBCares@ucb.com |
- AS0007
- 2016-000343-14