Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Cell Lymphoma After Autologous Transplant

Sponsor

University of Pennsylvania (Other)

Overall Status

Completed

CT.gov ID

NCT00434629

Collaborator

GlaxoSmithKline (Industry)

Enrollment

Location

98.9

Duration (Months)

0.2

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

Patients with B-cell lymphoma who relapse after autologous transplant tend to have a poor prognosis. Currently, there is no standard treatment for such patients. Bexxar is a radioactive antibody therapy that has shown a 60-80% response rate in non-transplanted patients with relapsed B-cell lymphoma. This study will test the safety and efficacy of Bexxar in the treatment of patients whose B-cell lymphoma has relapsed after an autologous transplant.

Condition or Disease	Intervention/Treatment	Phase
B-cell Lymphoma Non-Hodgkin's Lymphoma	Drug: Bexxar	Phase 1

Detailed Description

High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) has become the standard of care for relapsed/refractory chemotherapy-sensitive non-Hodgkin's lymphomas (NHL). However, one-half to two-thirds of such patients will relapse after ASCT, with subsequent poor prognosis, and new therapies are urgently needed for this patient population. Radioimmunotherapy (RIT) as a single agent therapy in patients with CD20 antigen-expressing relapsed or refractory low-grade, follicular, or transformed NHL has demonstrated overall response rates of 60-80% and has been approved by the FDA for use in this setting. While RIT is currently under investigation as a component of conditioning regimens for ASCT, the safety and efficacy of RIT after ASCT has not yet been well described. We will conduct a single-center Phase I dose-escalation trial of Bexxar (Tositumomab and 131I Tositumomab) for treatment of relapsed or residual CD20 antigen-expressing B-cell lymphomas following ASCT. Our primary aim will be to determine the safety, dose-limiting toxicity, and maximum tolerated dose of Bexxar in this post-ASCT patient population. Our secondary aim will be to describe the overall response rate, progression-free survival, time to treatment failure, and overall survival. Should Bexxar prove to be safe in this population, subsequent trials will be designed to investigate further the efficacy of RIT in the post-transplant setting.

Study Design

Study Type:

Interventional

Actual Enrollment :

16 participants

Allocation:

Non-Randomized

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

A Phase I Study of Bexxar® (Tositumomab and 131I-Tositumomab) Radioimmunotherapy in Patients With Relapsed or Residual CD20 Antigen-Expressing B-Cell Lymphomas Following Autologous Hematopoietic Stem Cell Transplantation

Study Start Date :

Feb 1, 2007

Actual Primary Completion Date :

May 1, 2015

Actual Study Completion Date :

May 1, 2015

Outcome Measures

Primary Outcome Measures

dose-limiting toxicity [Week 7 after Bexxar]
maximum tolerated dose [Week 7 after Bexxar]

Secondary Outcome Measures

overall response rate [Week 13 after Bexxar]
progression-free survival [5 years after Bexxar]
time to treatment failure [5 years after Bexxar]

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 75 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

CD20 positive B-cell lymphoma
Confirmed relapsed/refractory disease following autologous transplant
Age ≤ 75 years
Performance status 0 or 1
Creatinine ≤ 1.5 or calculated creatinine clearance ≥ 60 ml/min
Total bilirubin, AST, and ALT ≤ 1.5 x upper limit of normal (unless bilirubin due to Gilbert's)
No active CNS disease
No detectable bone marrow involvement by lymphoma on histopathologic bone marrow examination
Bone marrow cellularity ≥ 15% on histopathologic bone marrow examination
Availability of adequate stored autologous stem cell product (≥ 2 x 106 CD34+ cells/kg)

Exclusion Criteria:

Active infection
Pregnant woman are excluded from the study
Subjects not using contraceptives are excluded from the study
ANC ≤ 1,500/μL and/or platelet count ≤ 100,000/μL
Life expectancy of ≤ 2 months
Prior anti-B-cell radioimmunotherapy (e.g., Zevalin or Bexxar) [Patients who have received prior anti-B-cell monoclonal antibody therapy (e.g., rituximab or epratuzumab) will NOT be excluded.]
Prior total body radiation therapy
Positive human anti-mouse antibody (HAMA) testing