Letermovir for the Prevention of Cytomegalovirus Reactivation in Patients With Hematological Malignancies Treated With Alemtuzumab

Sponsor

Ohio State University Comprehensive Cancer Center (Other)

Overall Status

Recruiting

CT.gov ID

NCT04312841

Collaborator

Merck Sharp & Dohme LLC (Industry)

Enrollment

Location

Arm

27.5

Anticipated Duration (Months)

1.1

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

This phase II trial studies how well letermovir works for the prevention of cytomegalovirus reactivation in patients with hematological malignancies treated with alemtuzumab. Patients receiving treatment with alemtuzumab may experience cytomegalovirus reactivation. Letermovir may block cytomegalovirus replication and prevent infection.

Condition or Disease	Intervention/Treatment	Phase
B-Cell Prolymphocytic Leukemia Chronic Lymphocytic Leukemia Peripheral T-Cell Lymphoma Primary Cutaneous T-Cell Non-Hodgkin Lymphoma Sezary Syndrome T-Cell Prolymphocytic Leukemia	Drug: Letermovir	Phase 2

Detailed Description

PRIMARY OBJECTIVE:

To estimate the rate of cytomegalovirus (CMV) reactivation in patients treated with letermovir at 3 months after completion of alemtuzumab therapy.

SECONDARY OBJECTIVES:

To evaluate the tolerability of letermovir in combination with alemtuzumab.
To evaluate the efficacy of letermovir for the prevention of clinically significant CMV disease.
To estimate the progression free survival of patients in the study population.
To estimate the overall survival of patients in the study population.

EXPLORATORY OBJECTIVE:

To evaluate mechanisms of antiviral resistance in letermovir prophylaxis failures.

OUTLINE:

Beginning within 7 days of the first administration of standard alemtuzumab, patients receive letermovir orally (PO) (or intravenously [IV] over 1 hour if patient is unable to take PO for an extended period of time) daily on days 1-28. Cycles repeat every 28 days for up to 3 months after the last dose of alemtuzumab in the absence of unacceptable toxicity.

After completion of study treatment, patients are followed up at 30 days.

Study Design

Study Type:

Interventional

Anticipated Enrollment :

30 participants

Allocation:

N/A

Intervention Model:

Single Group Assignment

Masking:

None (Open Label)

Primary Purpose:

Treatment

Official Title:

Letermovir for Cytomegalovirus Prophylaxis in Patients With Hematological Malignancies Treated With Alemtuzumab

Actual Study Start Date :

Sep 15, 2020

Anticipated Primary Completion Date :

Dec 31, 2022

Anticipated Study Completion Date :

Dec 31, 2022

Arms and Interventions

Arm	Intervention/Treatment
Experimental: Treatment (letermovir) Beginning within 7 days of the first administration of standard alemtuzumab, patients receive letermovir PO (or IV over 1 hour if patient is unable to take PO for an extended period of time) daily on days 1-28. Cycles repeat every 28 days for up to 3 months after the last dose of alemtuzumab in the absence of unacceptable toxicity.	Drug: Letermovir Given PO Other Names: 2-((4S)-8-Fluoro-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)-4H-quinazolin-4-yl)acetic Acid AIC246 MK-8228 Prevymis

Arm

Intervention/Treatment

Experimental: Treatment (letermovir)

Beginning within 7 days of the first administration of standard alemtuzumab, patients receive letermovir PO (or IV over 1 hour if patient is unable to take PO for an extended period of time) daily on days 1-28. Cycles repeat every 28 days for up to 3 months after the last dose of alemtuzumab in the absence of unacceptable toxicity.

Drug: Letermovir

Given PO

Other Names:

2-((4S)-8-Fluoro-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3-(2-methoxy-5-(trifluoromethyl)phenyl)-4H-quinazolin-4-yl)acetic Acid

AIC246

MK-8228

Prevymis

Outcome Measures

Primary Outcome Measures

Cytomegalovirus (CMV) reactivation [During prophylaxis treatment (3 months after last dose of alemtuzumab)]
Defined as the proportion of patients who experience CMV reactivation (CMV deoxyribonucleic acid [DNA] by real time polymerase chain reaction > 500 IU/mL) during prophylaxis period among all patients who receive >= 90% of planned letermovir doses. The rate will be provided with 95% binomial confidence interval.

Secondary Outcome Measures

Incidence of adverse events [Up to 30 days post treatment]
Adverse event data will be described and graded per the National Cancer Institute Common Terminology Criteria for Adverse Events version 5.0 guidelines. The maximum grade for each type of toxicity will be recorded for each patient, and frequency tables will be reviewed to determine toxicity patterns, especially for grade 3 or above adverse events. To assess tolerability, will also capture the proportion of patients who go off treatment due to adverse events.
Development of CMV disease [Up to 2 years]
Clinically significant CMV reactivation be determined per the Disease Definitions Working Group of the Cytomegalovirus Drug Development Forum.
Progression free survival (PFS) [From trial enrollment to the occurrence of progression and death, assessed up to 2 years]
PFS will be estimated with the method of Kaplan-Meier (KM), where KM curves will be drawn to aid with visualization and estimates provided with 95% confidence intervals.
Overall survival (OS) [From trial enrollment to the occurrence of death due to any cause, assessed up to 2 years]
OS will be estimated with the method of KM, where KM curves will be drawn to aid with visualization and estimates provided with 95% confidence intervals.

Other Outcome Measures

Genotyping of mutations in CMV terminase complex genes [Up to 2 years]
CMV DNA sequence analysis to be performed only in subjects with CMV reactivation. Resistance to letermovir will be monitored by retrospective genotypic analysis of the CMV terminase genes in CMV DNA extracts from selected plasma samples collected at the time of diagnosed CMV reactivation. Samples will be analyzed by standard population sequencing technology through an established contract laboratory with validated protocols in place.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria:

Confirmed diagnosis of T-cell or B-cell prolymphocytic leukemia, chronic lymphocytic leukemia, peripheral T-cell lymphoma, cutaneous T-cell lymphoma, or Sezary syndrome
Intent to treat with alemtuzumab. Monotherapy or combination with chemotherapy is allowed
Confirmed seropositivity for CMV IgG (>= 0.7 U/mL) within 1 year of first letermovir dose
Confirmed lack of active CMV infection as evidenced by:
Undetectable CMV deoxyribonucleic acid (DNA) by Abbott RealTime CMV in vitro polymerase chain reaction assay (< 50 IU/mL) within 7 days of first letermovir dose AND
Negative CMV IgM (< 30 AU/mL) within 7 days of first letermovir dose
Able to provide informed consent
Life expectancy > 4 months
Eastern Cooperative Oncology Group (ECOG) performance status =< 3
Highly unlikely to become pregnant or impregnate a partner by meeting at least one of the following:
A female subject who is not of reproductive potential is eligible without requiring the use of contraception. A female subject who is not of reproductive potential is defined as one who:
Has reached natural menopause (defined as 6 months of spontaneous amenorrhea with serum follicle-stimulating hormone [FSH] levels in the postmenopausal range as determined by the local laboratory, or 12 months of spontaneous amenorrhea) OR
Is 6 weeks post-surgical bilateral oophorectomy with or without hysterectomy OR
Has undergone bilateral tubal ligation. Spontaneous amenorrhea does not include cases for which there is an underlying disease that causes amenorrhea (e.g., anorexia nervosa)
A male subject who is not of reproductive potential is eligible without requiring the use of contraception. A male subject who is not of reproductive potential is defined as one whom has undergone a successful defined as:
Microscopic documentation of azoospermia OR
A vasectomy more than 2 years ago with no resultant pregnancy despite sexual activity post-vasectomy
A male or female subject who is of reproductive potential agrees to true abstinence or to use (or have their partner use) an acceptable method of birth control starting from the time of consent through 90 days after the last dose of study therapy. True abstinence is defined as abstinence in line with the preferred and usual lifestyle of the subject. Periodic abstinence (e.g., abstinence only on certain calendar days, abstinence only during ovulation period, use of symptothermal method, use of post-ovulation methods) and withdrawal are not acceptable methods of contraception. Acceptable methods of birth control are:
Intrauterine device (IUD), diaphragm with spermicide, contraceptive sponge, condom, and vasectomy OR use of appropriate double barrier contraception. Hormonal contraceptives (e.g., birth control pills, transdermal patch, or injectables) are also acceptable

Exclusion Criteria:

History of confirmed CMV disease within 1 year of study entry
History of prior allogeneic hematopoietic stem cell transplant
End stage renal disease with creatinine clearance < 10 mL/min as defined by Cockcroft-Gault equation using serum creatinine within 7 days of enrollment
Child-Pugh class C within 7 days of enrollment
Serum aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 5 times the upper limit of normal (ULN) or serum total bilirubin > 2.5 x ULN
Note: Subjects who meet this exclusion criterion may, at the discretion of the investigator, have one repeat testing done. If the repeat value does not meet this criterion, they may continue in the screening process. Only the specific out of range value should be repeated (not the entire panel)
Both moderate hepatic insufficiency AND moderate renal insufficiency:
Moderate hepatic insufficiency is defined as Child Pugh Class B
Moderate renal insufficiency is defined as a creatinine clearance less than 50 mL/min, as calculated by the Cockcroft-Gault equation
Cytopenias are NOT an exclusion criteria in this trial as cytopenias are common in this patient population and letermovir has no known adverse effects on blood counts. Patients will be treated per institutional standard of care with as needed transfusions and growth factor support
Received any of the following drugs within 7 days of enrollment or plans to receive any of the following during the study:
Ganciclovir
Valganciclovir
Foscarnet
Acyclovir (at doses > 3200 mg PO per day or > 25 mg/kg IV per day)
Valacyclovir (at doses > 3000 mg PO per day)
Famciclovir (at doses > 1500 mg PO per day)
Cyclosporine A
Pimozide
Ergot alkaloids (ergotamine and dihydroergotamine)
Atorvastatin at doses greater than 20 mg daily
Received any of the following within 30 days prior to enrollment
Cidofovir
CMV hyper-immune globulin
Any investigational CMV antiviral agent/biologic therapy
Infection or underlying disease necessitating ongoing use of prohibited medications
Suspected or known hypersensitivity to active or inactive ingredients of letermovir formulations
Positive at the time of screening for:
Human immunodeficiency virus (HIV) with CD4 count < 350. If HIV positive, must remain on antiretroviral therapy that is not anticipated to interact with letermovir throughout study
Hepatitis B surface antigen or core antibody positivity associated with detectable viral load. For any patient with serologic evidence of prior infection but undetectable viral load, viral load and surface antigen will be monitored every 2 weeks. Those with evidence of reactivation (detectable viral load) will be treated with entecavir or lamivudine. Upon resolution of detectable viral load, the patient will be allowed to continue on trial assuming adequate liver function as defined above. Alternatively, patients may be put on prophylactic entecavir or lamivudine to prevent hepatitis B reactivation at the investigator's discretion
Hepatitis C if no prior or current curative antiviral therapy. For those currently on curative antiviral therapy, they will be allowed on trial if hepatitis C virus (HCV) quantitation is below the limit of detection and adequate liver function as above
Pregnant or expecting to conceive, is breastfeeding, or plans to breastfeed from the time of consent through 90 days after the last dose of study therapy
Expecting to donate eggs or sperm starting from the time of consent through 90 days after the last dose of study therapy
Currently participating or has participated in a study with an unapproved investigational compound or device within 28 days, or 5X half-life of the investigational compound (excluding monoclonal antibodies), whichever is longer, of initial dosing on this study. Subjects previously treated with a monoclonal antibody will be eligible to participate after a 28-day washout period
Previous participation in a study using letermovir
Has a history or current evidence of any condition, therapy, lab abnormality, or other circumstance that might confound the results of the study, interfere with the subject's participation for the full duration of the study, or would be put at undue risk as judged by the investigator, such that it is not in the best interest of the subject to participate in this study