polymorphism: B2 Adrenergic Receptor Gene Polymorphism in Bronchial Asthma

Sponsor

Assiut University (Other)

Overall Status

Unknown status

CT.gov ID

NCT03118869

Collaborator

(none)

Enrollment

Location

Anticipated Duration (Months)

10.8

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection. The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection, Enhanced mucociliary clearance.

The b2AR gene is located on chromosome 5q31-q32, a region that is genetically linked to asthma and related phenotypes. There are three best known polymorphisms in the coding region of the b2AR gene that can modulate the function of the receptor.

Condition or Disease	Intervention/Treatment	Phase
Gene Abnormality Asthma

Detailed Description

Asthma is a complex disease and has a strong genetic component in its pathogenesis. So far, considerable efforts have been made to evaluate the association between genetic variants and asthma risk, and numerous genes have been identified as asthma Reporting Items susceptible genes.

Study Design

Study Type:

Observational

Anticipated Enrollment :

75 participants

Observational Model:

Case-Only

Time Perspective:

Prospective

Official Title:

B2adrenergic Receptor Gene Polymorphism in Bronchial Asthma: Relation to Disease Severity and Control

Actual Study Start Date :

Apr 1, 2017

Anticipated Primary Completion Date :

Oct 1, 2017

Anticipated Study Completion Date :

Oct 30, 2017

Outcome Measures

Primary Outcome Measures

To measure number of patient with homozygous and heterozygous B2AD gene polymorphisms with focus on Arg/Gly16 and Gln/Glu27 polymorphism [1 month]
study of prevalence homozygote and heterozygote patients

Secondary Outcome Measures

Number of patient with b2AR gene polymorphisms in different asthma severity and different response of treatment of asthma ( Arg/Gly16 and Gln/Glu27 polymorphism) [1 month]
correlation between polymorphism and pulmonary function test and level of disease control

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 65 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

patients diagnosed as asthma according to GINA guideline 2016.
Allergic asthma

Exclusion Criteria:

pneumonia
chronic cardiac, hepatic and renal diseases
pregnancy and lactation
malignancy

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	AssiutU	Assiut		Egypt	71111

Sponsors and Collaborators

Assiut University

Investigators

Principal Investigator: Aliae Mohamed-Hussein, Professor of Pulmonology- Faculty of Medicine-Assiut University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

Aliae AR Mohamed Hussein, Prof. Dr. Aliae AR Mohamed-Hussein, Professor of Pulmonology, Assiut University

ClinicalTrials.gov Identifier:

NCT03118869

Other Study ID Numbers:

AssiutU3

First Posted:

Apr 18, 2017

Last Update Posted:

Aug 28, 2017

Last Verified:

Aug 1, 2017

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Studies a U.S. FDA-regulated Drug Product:

Studies a U.S. FDA-regulated Device Product:

Keywords provided by Aliae AR Mohamed Hussein, Prof. Dr. Aliae AR Mohamed-Hussein, Professor of Pulmonology, Assiut University

Asthma

B2 adrenergic receptors

Polymorphism

Additional relevant MeSH terms:

Asthma

Study Results

No Results Posted as of Aug 28, 2017