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Biomarkers of Ischemia: Xanthine, Hypoxanthine and Inosine Levels During Carotid Stenting Procedures

Sponsor
Virginia Commonwealth University (Other)
Overall Status
Completed
CT.gov ID
NCT01639534
Collaborator
(none)
10
Enrollment
1
Location
31.3
Duration (Months)
0.3
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The purpose of the study is to determine if a new blood test can help the doctor determine if there is brain injury or ischemia. Ischemia occurs when not enough oxygen gets to the brain. In this study the investigators are analyzing your blood for a new test that might help doctors decide if symptoms are from a neurologic problem.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    We will compare a new blood test with routine tests that the doctor will order as part of your normal care. This study will measure new biomarkers (biomarker is a specific distinguishing feature used to measure or indicate the effects or progress of a disease or condition) of neurologic stress called xanthine, hypoxanthine, and inosine. Blood will be drawn as a part of the study to measure these biomarker levels in your blood. This blood will be analyzed i the laboratory at Virginia Commonwealth University and possibly at a future date at another institution. No names will be associated with the blood sample

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    10 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Other
    Official Title:
    Biomarkers of Ischemia: Xanthine, Hypoxanthine and Inosine Levels During Carotid Stenting Procedures
    Study Start Date :
    Mar 1, 2011
    Actual Primary Completion Date :
    Oct 9, 2013
    Actual Study Completion Date :
    Oct 9, 2013

    Arms and Interventions

    Arm Intervention/Treatment
    Biomarkers, Carotid Stenting, Blood sample

    Subjects requiring Carotid Stenting Procedure at Virginia Commonwealth University/Medical College of Virginia Health Systems

    Outcome Measures

    Primary Outcome Measures

    1. Biomarkers of Ischemia: Levels of Xanthine, Hypoxanthine and Inosine during Carotid Stenting Procedures [analysis will occur after all samples collected]

      To compare a new blood test with can help the doctor determine if there is a brain injury or ischemia, The study will measure new biomarkers of neurologic stress called xanthine, hypoxanthine and inosine. Blood will be drawn as a part of the study to measure these biomarker levels in the blood. The blood will be analyzed in the laboratory at VCU.

    Eligibility Criteria

    Criteria

    Ages Eligible for Study:
    18 Years and Older
    Sexes Eligible for Study:
    All
    Accepts Healthy Volunteers:
    No
    Inclusion Criteria:

    • Men and Women over age of 18 non

    • Women who are not pregnant

    • Subject who are not prisoners

    • Subjects presenting to the operation room for a Carotid artery stenting procedure

    • Hemoglobin greater than or equal to 11mg/dl

    • Subjects who speak english

    • Subjects 18 years of age or older

    Exclusion Criteria:

    • Hemoglobin less than 11mg/dl

    • Women who are pregnant

    • Children under age of 18

    • Prisoners

    • Non English

    Contacts and Locations

    Locations

    Site City State Country Postal Code
    1 Virginia Commonwealth University Richmond Virginia United States 23298

    Sponsors and Collaborators

    • Virginia Commonwealth University

    Investigators

    • Principal Investigator: Lynne Gehr, MD, Virginia Commonwealth University

    Study Documents (Full-Text)

    None provided.

    More Information

    Publications

    None provided.
    Responsible Party:
    Virginia Commonwealth University
    ClinicalTrials.gov Identifier:
    NCT01639534
    Other Study ID Numbers:
    • HM12941
    First Posted:
    Jul 12, 2012
    Last Update Posted:
    Jul 31, 2018
    Last Verified:
    Jul 1, 2018
    Keywords provided by Virginia Commonwealth University
    Biomarkers of ischemia
    Carotid Stenting procedure
    Levels Xanthine Hypoxanthine and Inosine
    peripheral blood
    Additional relevant MeSH terms:
    Ischemia

    Study Results

    No Results Posted as of Jul 31, 2018