Biomarkers and Mechanisms of Disease Progression and Outcome of Aortic Stenosis in Humans
Study Details
Study Description
Brief Summary
Biomarkers and mechanisms in the progression of aortic valve stenosis are sometimes not sufficiently understood. The current project will take into account image morphological and immunological aspects that predict the development of hemodynamically relevant aortic valve stenosis in order to identify high-risk patients and to develop further therapeutic options.
Condition or Disease | Intervention/Treatment | Phase |
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Detailed Description
Early recognition and management of aortic stenosis (AS) are substantial to avoid life threatening events during the clinical course. Multi-factorial complex mechanisms including fibrosis, oxidative stress, inflammation, angiogenesis, osteogenic differentiation and the effect of genetic risk variants have been proposed to be involved mechanistically in the pathogenesis of degenerative AS. It is crucial to identify the potentially involved mechanisms of AS progression in order to 1) identify patients at risk for pronounced cardiac damage and adverse outcomes that might benefit from early aortic valve replacement and 2) to discover treatment options that might slow down progression and lower adverse clinical events.
The consortium´s work has revealed that various inflammatory events play a substantial role for the onset and progression of aortic valve calcification and stenosis in cell culture and small animal experiments We hypothesize that patients with and without rapid progress to severe aortic stenosis differ in terms of genetic, immunological and imaging parameters early in the disease course, and that these parameters can be combined to create strong and reliable predictors of disease progression. Hence, we plan to assess multiple morphological, functional, genetic and immunological readouts and investigate their capacity to predict disease progression in AS in a clinical observational cohort of 938 patients with moderate AS.
This project is a working package as part of TRR259, which is a collaborative project between the three universities: Bonn, Cologne and Düsseldorf.
Study Design
Outcome Measures
Primary Outcome Measures
- progress of aortic stenosis [5 years]
Prevalence (number of participants) measured by transthoracic echocardiography
Secondary Outcome Measures
- hospitalization [5 years]
Rate of patients (%) being hospitalized due to a progress of aortic stenois
- death [5 years]
- occurence of myocardial infarction [5 years]
- occurence of stroke [5 years]
Eligibility Criteria
Criteria
Inclusion Criteria:
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The patient has an acquired (tricuspid) moderate aortic valve stenosis, which is the reason for regular outpatient cardiological care.
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The subject has been informed verbally and in writing about the study and has given written consent to participate in this study.
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Age > 18 years
Exclusion Criteria:
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The subject has contraindications for the performance of a magnetic resonance imaging or computed tomography (e.g., severe arrhythmias , contrast agent intolerance, a pacemaker, or severe renal insufficiency or severe renal insufficiency or claustrophobia).
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Presence of only mild or already high-grade acquired tricuspid Aortic valve stenosis
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Patient with bicuspid aortic valve
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Inability to follow the instructions of study personnel
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Lack of written informed consent
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
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1 | University-Hospital Bonn | Bonn | Germany | 53127 | |
2 | University Hospital Cologne | Cologne | Germany | 50937 | |
3 | University-Hospital Düsseldorf Division of Cardiology, Pulmonary Disease and Vascular Medicine | Düsseldorf | Germany | 40225 |
Sponsors and Collaborators
- Heinrich-Heine University, Duesseldorf
- German Research Foundation
- University Bonn
- University Cologne
- Collaborative Research Center
Investigators
- Study Chair: Malte Kelm, Prof., Clinic for Cardiology, Pneumology and Angiology at University Hospital Düsseldorf
- Study Chair: Georg Nickenig, Prof., University Bonn
- Study Chair: Stephan Baldus, Prof., University Cologne
Study Documents (Full-Text)
None provided.More Information
Additional Information:
Publications
None provided.- TRR259 C06