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Glioma: Blood Flow MRI for Monitoring Brain Tumors

Sponsor
Beth Israel Deaconess Medical Center (Other)
Overall Status
Active, not recruiting
CT.gov ID
NCT01538264
Collaborator
National Cancer Institute (NCI) (NIH)
125
Enrollment
1
Location
187
Duration (Months)
0.7
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

The investigators are studying the use of an advanced magnetic resonance imaging (MRI) technique for measuring blood flow into brain tumors. This technique does not use radioactive tracers, and it can provide high quality images that can be obtained in a standard MRI scanner.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Our goals are:

    1. To compare the blood flow measured with this technique with measures of tumor blood vessel density in pieces of the tumor surgically removed as a normal part of clinical treatment. This will confirm a relationship between the imaging measurements and the microscopic characteristics of tumors.

    2. To compare the blood flow in tumors before therapy with the concentration of choline, an indicator of cell proliferation. This choline concentration can be measured with another MRI technique. This information will demonstrate the relationship between cell proliferation and blood supply and will also determine whether the choline measurement adds additional information that is clinically necessary.

    3. To determine the reproducibility of blood flow measurements in tumors. This is necessary to better understand the sensitivity of the technique to changes in flow caused by a treatment or changes in tumor vascularity.

    4. To monitor changes in blood flow after initial treatment. Since sometimes tumors can reappear, the repeated measures will help determine how useful this new imaging technique is at detecting such recurring tumors.

    Study Design

    Study Type:
    Observational
    Anticipated Enrollment :
    125 participants
    Observational Model:
    Case-Only
    Time Perspective:
    Cross-Sectional
    Official Title:
    Blood Flow MRI for Monitoring of Glioma Angiogenesis
    Study Start Date :
    Jun 1, 2006
    Anticipated Primary Completion Date :
    Dec 31, 2021
    Anticipated Study Completion Date :
    Dec 31, 2021

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      18 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      No
      Inclusion Criteria:
      • diagnosed with or are suspected of having a glioma
      Exclusion Criteria:
      • contraindications to MRI which may include the following

      1. Pacemaker

      2. MRI incompatible metal implant

      3. Recently implanted vascular clip

      4. History of claustrophobia

      5. Metal fragment within the eye

      Subjects who have received nonstandard therapy may be excluded if the therapy might alter tumor blood flow or other imaging characteristic.

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Beth Israel Deaconess Medical Center Boston Massachusetts United States 02215

      Sponsors and Collaborators

      • Beth Israel Deaconess Medical Center
      • National Cancer Institute (NCI)

      Investigators

      • Principal Investigator: David C Alsop, PhD, Beth Israel Deaconess Medical Center

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      David Alsop, Professor of Radiology, Beth Israel Deaconess Medical Center
      ClinicalTrials.gov Identifier:
      NCT01538264
      Other Study ID Numbers:
      • 2006P000116
      • R01CA115745-05
      First Posted:
      Feb 24, 2012
      Last Update Posted:
      Sep 10, 2020
      Last Verified:
      Sep 1, 2020
      Individual Participant Data (IPD) Sharing Statement:
      No
      Plan to Share IPD:
      No
      Additional relevant MeSH terms:
      Brain Neoplasms

      Study Results

      No Results Posted as of Sep 10, 2020