Eccentric Resistance Training With Blood Flow Restriction on Muscle Function

Sponsor

Sara Harper (Other)

Overall Status

Not yet recruiting

CT.gov ID

NCT04977804

Collaborator

(none)

Enrollment

Arms

Anticipated Duration (Months)

Study Details

Study Description

Brief Summary

The study will determine the effects of adding blood flow restriction to eccentric training to assess whether this increases the improvements of muscle strength and size.

Condition or Disease	Intervention/Treatment	Phase
Blood Flow Restriction	Other: Exercise Other: Eccentric plus blood-flow restriction	N/A

Detailed Description

Subjects will be randomly assigned to two groups: an eccentric only resistance training group or an eccentric training plus blood flow restriction group. Subjects will train at a moderately low intensity on a multiple-joint eccentric device. Those in the blood flow restriction will wear blood flow restriction cuffs on their upper thighs to reduce blood flow during the brief protocol. The training session will occur twice per week and will last ~5 minutes, including a one minute warm up, a one minute cool down and a three minute workout phase. The training program will last 7 weeks. Testing will be conducted at baseline (following a one session familiarization), 4 weeks and after the end of the 7 week training period. Assessments will focus on muscle strength, function, and morphology (size).

Study Design

Study Type:

Interventional

Anticipated Enrollment :

30 participants

Allocation:

Randomized

Intervention Model:

Parallel Assignment

Intervention Model Description:

Two group, randomized parallel group design.Two group, randomized parallel group design.

Masking:

Single (Outcomes Assessor)

Masking Description:

The person assessing the outcome measures will be blinded to the group designation of the subjects.

Primary Purpose:

Basic Science

Official Title:

Effects of Blood Flow Restriction During Multiple-joint Eccentric Resistance Training on Muscle Morphology and Function of the Lower Body.

Anticipated Study Start Date :

Sep 30, 2022

Anticipated Primary Completion Date :

Apr 1, 2023

Anticipated Study Completion Date :

Apr 1, 2023

Arms and Interventions

Arm	Intervention/Treatment
Active Comparator: Eccentric only training This is the experimental control; where this group will be used as the standard active comparison condition.	Other: Exercise The interventions are a form or exercise, specifically resistance exercise.
Experimental: Eccentric plus blood-flow restriction This is the experimental condition involving the eccentric resistance training with blood flow restriction.	Other: Eccentric plus blood-flow restriction Eccentric plus blood-flow restriction

Arm

Intervention/Treatment

Active Comparator: Eccentric only training

This is the experimental control; where this group will be used as the standard active comparison condition.

Other: Exercise

The interventions are a form or exercise, specifically resistance exercise.

Experimental: Eccentric plus blood-flow restriction

This is the experimental condition involving the eccentric resistance training with blood flow restriction.

Other: Eccentric plus blood-flow restriction

Eccentric plus blood-flow restriction

Outcome Measures

Primary Outcome Measures

Eccentron maximal muscle strength [7 weeks]
Eccentric muscle strength will be assessed via Eccentron (BTE Technologies, Inc., USA), an seated isokinetic dynamometer.
Local muscle hypertrophy [7 weeks]
Muscle size changes of the quadriceps muscle measured an ultrasound device (GE NextGen LOGIQ, Tampa, Florida, USA).
Muscle mass [7 weeks]
dual energy x-ray absorptiometry device (DEXA) the Hologic Horizon W Dual X-ray absorptiometry (Hologic Canada ULC, Mississauga, ON, Canada) will be used to assess appendicular (lower body) mean mass.
Muscle function [7 weeks]
Vertical jump height will assess 3 maximal countermovement attempts on a jump mat (Just Jump Technologies, Huntsville, AL, USA) that measures jump height based on flight time.

Secondary Outcome Measures

Muscle soreness [7 weeks]
local muscle soreness will be assessed throughout the duration of the intervention period using a Wagner force algometer.

Eligibility Criteria

Criteria

Ages Eligible for Study:

18 Years to 30 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Yes

Inclusion Criteria:

18-30 years of age
currently engaged in some form of resistance training between 1-3 times per week
must have been training aerobically, but no more than 3 hours a week for the past six months

Exclusion Criteria:

Must not have had any surgery of the lower limbs within the past 1 year period
Must not have any neuromuscular disorder (e.g., Muscular dystrophy etc.)
< 76 inches tall (in order to fit on the training machine)
Maximal strength of < 725 lbs for the eccentric training device
If any of the subjects are pregnant or plan to be pregnant in the duration of the protocol.

For those randomized to the BFR group, if any of the subject's thighs are too large for the BFR cuffs (greater than 68 cm).