Impact of Bean Polyphenols and Phytic Acid on Iron Absorption

• Sponsor: Swiss Federal Institute of Technology (Other)
• Overall Status: Completed
• CT.gov ID: NCT01472484
• Collaborator: (none)
• Enrollment: 20
• Location: 1
• Arms: 4
• Duration (Months): 1
• Patients Per Site Per Month: 19.6

Study Details

Study Description

Brief Summary

Recently isolated low PA varieties (lpa) in wheat, rice, maize, barley and beans might have the potential to alleviate iron bioavailability problems associated with PA. These plants have normal phosphate levels, but reduced PA phosphate due to various modifications of the biosynthetic pathway of PA. So far lpa crops are in an early stage of development, most of them exhibiting reduced yield and seed germination. However, the lpa bean isolated by Campion and co-workers 2009 by chemical mutagenesis exhibited only 10 % of the native bean PA concentration without any defects in terms of growth and yield.

Crossing the lpa variety with bean varieties low in PP and high in iron might lead to the development of a variety which has the potential to improve the iron status of bean consuming populations.

The following study will evaluate the relative impact of PA and PP on iron absorption from beans by comparing iron absorption from four different bean varieties. Iron absorption from a bean with normal PA concentration and high PP concentration will be compared to iron absorption from a bean with normal PA and low PP concentration as well as to two lpa varieties, one with high and one with low PP concentration.

Condition or Disease	Intervention/Treatment	Phase
Blood Iron Isotope Enrichment	Other: 586/8x87 white; Other: 586/8x87 brown; Other: BAT 881; Other: 586/8	N/A

Study Design

• Study Type: Interventional
• Actual Enrollment: 20 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: Single (Participant)
• Primary Purpose: Basic Science
• Official Title: A Stable Iron Isotope Study to Investigate the Impact of Phytic Acid and Polyphenols on Iron Absorption From Beans in Humans
• Study Start Date: Dec 1, 2011
• Actual Primary Completion Date: Jan 1, 2012
• Actual Study Completion Date: Jan 1, 2012

Arms and Interventions

Arm	Intervention/Treatment
Experimental: lpa with high polyphenol	Other: 586/8x87 brown; 2 x 50 g
Experimental: lpa with low polyphenol	Other: 586/8x87 white; 2 x 50 g
Experimental: control bean with low polyphenol	Other: 586/8; 2 x 50 g
Experimental: control bean with high polyphenol	Other: BAT 881; 2 x 50 g

Outcome Measures

Primary Outcome Measures

1. Shift in iron isotopic composition in blood after consumption of different bean varieties [1 month]

Eligibility Criteria

Criteria

• Ages Eligible for Study: 18 Years to 40 Years
• Sexes Eligible for Study: Female
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• Non-pregnant, non-lactating women

• Between 18 and 40 years

• Below 65kg

Exclusion Criteria:

• Metabolic, chronic and gastro-intestinal disease

• Long-term medication

• Blood donation within 6 month before the study

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	ETH	Zurich		Switzerland	8092

Sponsors and Collaborators

• Swiss Federal Institute of Technology

Investigators

• Principal Investigator: Richard Hurrell, Prof. Dr., ETH Zürich

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• Responsible Party: Prof. Michael B. Zimmermann, Prof, Swiss Federal Institute of Technology
• ClinicalTrials.gov Identifier: NCT01472484
• Other Study ID Numbers: lpa_586/8X87
• First Posted: Nov 16, 2011
• Last Update Posted: Jun 19, 2012
• Last Verified: Jun 1, 2012

• Keywords provided by Prof. Michael B. Zimmermann, Prof, Swiss Federal Institute of Technology: beans; lpa mutant; polyphenols; phytic acid; stable iron isotopes

Study Results

No Results Posted as of Jun 19, 2012