Blood Levels of Sevoflurane and Desflurane

Sponsor

Cukurova University (Other)

Overall Status

Completed

CT.gov ID

NCT03015350

Collaborator

(none)

Enrollment

Location

Duration (Months)

1.3

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

16 patients with American Society of AnesthesioIogy (ASA) physical status I-III will recruited to this study. Patients will divided to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D. Each groups will divide 2 subgroups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. At the time point 40.minutes first blood sample will given from patients. Blood sample will be taken at intervals of 10 minutes from groups of two lung ventilation. In groups of one lung ventilation, blood samples will be taken at the time interval of 10 minutes after one lung ventilation started. All blood samples will be assess in Gas Chromatography.

Condition or Disease	Intervention/Treatment	Phase
Anesthetics, Inhalation	Drug: Sevoflurane Drug: Desflurane

Detailed Description

Investigator aimed to assess blood level of sevoflurane and desflurane during two lung ventilation and one lung ventilation. The investigators will use Gas Chromatography for define drugs levels. 16 patients with ASA I-III patients who undergo thoracotomy and abdominal surgery will be recruited to this study. Patients will divided in to the 2 groups. %1.5 Sevoflurane will apply in Group S and %6 Desflurane will apply in Group D during anesthesia maintenance. Each groups will divide 2 subgroups which are one lung ventilation groups and two lung ventilation groups. Two lung ventilation will be performed to Group Sa and Group Da, one lung ventilation will be performed to Group Sb and Group Db. Sequential blood samples will be taken from both arterial and central venous canula at the same time point. First blood samples will be taken at 40. minutes of anesthesia. Sequential samples will be taken at interval of 10 minutes during two lung ventilation. In one lung ventilation second blood samples will be taken at the 10. minutes of one lung ventilation. After than at the interval of 10 minutes, collection of blood samples both arterial and central venous will be continue.

All collection will assess with gas chromatography.

Study Design

Study Type:

Observational

Actual Enrollment :

16 participants

Observational Model:

Case-Control

Time Perspective:

Prospective

Official Title:

Blood Levels of Sevoflurane and Desflurane During One Lung Ventilation

Study Start Date :

Dec 1, 2016

Actual Primary Completion Date :

Dec 1, 2017

Actual Study Completion Date :

Dec 1, 2017

Arms and Interventions

Arm	Intervention/Treatment
two lung ventilation of Sevoflurane In GroupSa, 1,5 % sevoflurane will be apply continuously and blood samples will be taken at intervals of 10 minutes starting from the 40th minute.	Drug: Sevoflurane Measurement of blood desflurane level during one lung ventilation Other Names: Blood sevoflurane level
one lung ventilation of Sevoflurane In GroupSa, 1,5 % sevoflurane will be apply continuously and first samples will taken at the 40. minutes and collection of blood samples will be continue at intervals of 10 minutes after one lung ventilation started.	Drug: Sevoflurane Measurement of blood desflurane level during one lung ventilation Other Names: Blood sevoflurane level
two lung ventilation of Desflurane In GroupSa, 6 % desflurane will be apply continuously and blood samples will be taken at intervals of 10 minutes starting from the 40th minute.	Drug: Desflurane Measurement of blood desflurane level during one lung ventilation Other Names: Blood desflurane level
one lung ventilation of desflurane In GroupSa, 6 % desflurane will be apply continuously and first samples will taken at the 40. minutes and collection of blood samples will be continue at intervals of 10 minutes after one lung ventilation started.	Drug: Desflurane Measurement of blood desflurane level during one lung ventilation Other Names: Blood desflurane level

Outcome Measures

Primary Outcome Measures

Measurement of blood levels of Sevoflurane and Desflurane [from 40th minute to the end of the operation]
Data collections will be ensured from arterial and venous blood sample and than samples will be assessed with gas chromatography and blood sevoflurane and desflurane level will be measured. Blood samples will take every 10 minutes. Only blood levels of sevoflurane and desflurane will be assessed.

Secondary Outcome Measures

determine of ventilation-perfusion mismatch with p(A-a)O2 [from 40th minute to the end of the one lung ventilation]
During one lung ventilation, p(a-A)O2 will be assessed with arterial blood analyses

Eligibility Criteria

Criteria

Ages Eligible for Study:

25 Years to 65 Years

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

Inclusion Criteria: ASA I-II patients

Who undergo thoracotomy or abdominal surgery

Exclusion Criteria:

ASA IV and up patients
Patients who taken inotropic agent

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Ebru Biricik	Adana	In The USA Or Canada, Please Select...	Turkey	01380

Sponsors and Collaborators

Cukurova University

Investigators

Principal Investigator: Ebru Biricik, MD, Cukurova University

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

Responsible Party:

ebru biricik, MD, Anesthesiology specialist, Cukurova University

ClinicalTrials.gov Identifier:

NCT03015350

Other Study ID Numbers:

One lung ventilation

First Posted:

Jan 10, 2017

Last Update Posted:

Mar 5, 2018

Last Verified:

Nov 1, 2017

Individual Participant Data (IPD) Sharing Statement:

Plan to Share IPD:

Keywords provided by ebru biricik, MD, Anesthesiology specialist, Cukurova University

blood sevoflurane concentration

blood desflurane concentration

one lung ventilation

Additional relevant MeSH terms:

Respiratory Aspiration

Sevoflurane

Desflurane

Study Results

No Results Posted as of Mar 5, 2018