Efficacy of Tranexamic Acid in Preventing Post Operative Blood Loss in Bone Sarcoma Patient
Study Details
Study Description
Brief Summary
investigator will see the efficacy of tranexamic acid in limb salvage surgery patients which will prevent blood loss and help in conservation of blood products.
Condition or Disease | Intervention/Treatment | Phase |
---|---|---|
|
Early Phase 1 |
Study Design
Arms and Interventions
Arm | Intervention/Treatment |
---|---|
Placebo Comparator: placebo will injection 10 ml of normal saline to ensure binding |
Other: normal saline
normal saline will be injected to ensure placebo
|
Active Comparator: tranexamic acid(TXA) will inject tranexamic acid according to body weight |
Drug: Tranexamic acid injection
will inject tranexamic acid in limb salvage surgery of sarcoma patient to check its efficacy in preventing blood loss
|
Outcome Measures
Primary Outcome Measures
- blood loss [72 hour post operatively]
measure by hemoglobin direct method
- no of blood transfused [72 hour]
measured by number of transfusion
Secondary Outcome Measures
- duration of hospital stay [total hospital stay post operatively for 02 month]
Total days of hospital admission 2 months after surgery
- volume of drain out put [measure till drain out in 72 hour]
to measure blood collected in drain bottle
- thromboembolic events [observed for 6 week determine on out patient visits]
look for limb swelling for deep vein thrombosis and chest symptoms for any embolic event confirmed by CT chest
Eligibility Criteria
Criteria
Inclusion Criteria:
-
Limb sarcoma of upper and lower limb
-
Limb salvage
Exclusion Criteria:
-
liver insufficiency
-
renal insufficiency
-
allergic to drug
-
history of thromboembolic condition
-
pregnancy
-
metastatic disease
Contacts and Locations
Locations
Site | City | State | Country | Postal Code | |
---|---|---|---|---|---|
1 | Shaukat Khanum Memorial Cancer Hospital & Research Center | Lahore | Punjab | Pakistan |
Sponsors and Collaborators
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Investigators
None specified.Study Documents (Full-Text)
More Information
Publications
None provided.- IRB-22-07