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Study of Blood Platelets in Sickle Cell Disease

Sponsor
Rockefeller University (Other)
Overall Status
Withdrawn
CT.gov ID
NCT00226083
Collaborator
Icahn School of Medicine at Mount Sinai (Other), Schneider Children's Hospital of North Shore (Other)
0
Enrollment
1
Location
25
Duration (Months)
0
Patients Per Site Per Month

Study Details

Study Description

Brief Summary

We are studying if sickle cell disease blood platelets are larger than normal and how they may cause obstruction of blood vessels. We are also trying to study the reasons why large platelets are found in patients with sickle cell disease.

Condition or Disease Intervention/Treatment Phase

    Detailed Description

    Research volunteers are seen in the Outpatient Research Center by the Principal Investigator or another physician. A detailed history is obtained, a physical examination is performed, and blood (usually 4 tablespoons) is obtained for additional tests. The research volunteer's previous medical records will be requested. Upto 5 additional blood samples may be obtained in a subgroup of patients.

    Study Design

    Study Type:
    Observational
    Actual Enrollment :
    0 participants
    Time Perspective:
    Prospective
    Official Title:
    Studies of Large Platelets in Patients With Sickle Cell Disease
    Study Start Date :
    Aug 1, 2005
    Anticipated Primary Completion Date :
    Sep 1, 2007
    Anticipated Study Completion Date :
    Sep 1, 2007

    Outcome Measures

    Primary Outcome Measures

      Eligibility Criteria

      Criteria

      Ages Eligible for Study:
      7 Years and Older
      Sexes Eligible for Study:
      All
      Accepts Healthy Volunteers:
      Yes
      Inclusion Criteria:
      • Adults and children > 7 years of age with sickle cell disease (Hb SS) who are not taking hydroxyurea and are not receiving routine blood transfusion therapy.
      Exclusion Criteria:

      • Current hydroxyurea therapy or,

      • Hydroxyurea use within the past 3 months

      • Blood transfusion or exchange transfusion within the past 3 months

      • Current treatment with aspirin or clopidogrel

      Contacts and Locations

      Locations

      Site City State Country Postal Code
      1 Rockefeller University Hospital New York New York United States 10021

      Sponsors and Collaborators

      • Rockefeller University
      • Icahn School of Medicine at Mount Sinai
      • Schneider Children's Hospital of North Shore

      Investigators

      • Principal Investigator: Arun Shet, MD, Rockefeller University

      Study Documents (Full-Text)

      None provided.

      More Information

      Publications

      None provided.
      Responsible Party:
      Rockefeller University
      ClinicalTrials.gov Identifier:
      NCT00226083
      Other Study ID Numbers:
      • RUH IRB # AST-0565-0805
      First Posted:
      Sep 26, 2005
      Last Update Posted:
      Jun 9, 2015
      Last Verified:
      Jun 1, 2015
      Additional relevant MeSH terms:
      Anemia, Sickle Cell

      Study Results

      No Results Posted as of Jun 9, 2015