The Effect of Short-term L-citrulline Supplementation on Blood Pressure and Arterial Stiffness
Study Details
Study Description
Brief Summary
The goal of this clinical trial is to examine the effect of short-term L-Citrulline on central and peripheral blood pressure in healthy older adults. The main questions it aims to answer are:
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Does L-citrulline favorably affect blood pressure at rest and during exercise?
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Does L-citrulline favorably affect arterial stiffness?
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Does L-citrulline favorably affect muscle oxygenation at rest and during exercise?
Participants will be asked to consume L-citrulline and a placebo for six days and participate in the evaluation of their blood pressure, arterial stiffness, and muscle oxygenation before and after each intervention.
Researchers will compare L-citrulline and placebo groups to examine whether L-citrulline supplementation affects the above health parameters.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
N/A |
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| Experimental: L-Citrulline Participants will receive 6 g (3 g every 12 h) of L-citrulline (Now, L-citrulline Pure Powder) for six-days. |
Dietary Supplement: L-Citrulline
6 g (3 g every 12 h) of L-citrulline for six days
|
| Placebo Comparator: Placebo Participants will receive 6 g (3 g every 12 h) of maltodextrin (Now, Maltodextrin) for six-days. |
Dietary Supplement: Placebo
6 g (3 g every 12 h) of maltodextrin for six days
|
Outcome Measures
Primary Outcome Measures
- Change in aortic and brachial systolic blood pressure (rest) [Change from baseline aortic and brachial systolic blood pressure at 7 days.]
- Change in aortic and brachial systolic blood pressure [Change from baseline aortic and brachial systolic blood pressure at the second minute of exercise.]
- Change in carotid-femoral pulse wave velocity (cfPWV) (rest) [Change from baseline aortic and brachial systolic blood pressure at 7 days.]
Secondary Outcome Measures
- Change in pulse pressure (rest) [Change from baseline pulse pressure at 7 days.]
- Change in heart rate (rest) [Change from baseline heart rate at 7 days.]
- Change in augmented pressure (rest) [Change from baseline augmented pressure at 7 days.]
- Change in augmentation index (rest) [Change from baseline augmentation index at 7 days.]
- Change in forward and backward wave pressure (rest) [Change from baseline forward and backward wave pressure at 7 days.]
- Change in muscle oxyhemoglobin (rest) [Change from baseline oxyhemoglobin at 7 days.]
- Change in pulse pressure (exercise) [Change from baseline pulse pressure at the second minute of exercise.]
- Change in heart rate (exercise) [Change from baseline heart rate at the second minute of exercise.]
- Change in augmented pressure (exercise) [Change from baseline augmented pressure at the second minute of exercise.]
- Change in augmentation index (exercise) [Change from baseline augmentation index at the second minute of exercise.]
The ideal augmentation index is between 20 and 80. Values above 80 are considered high, and above 121 indicate high arterial stiffness.
- Change in forward and backward wave pressure (exercise) [Change from baseline forward and backward wave pressure at the second minute of exercise.]
- Change in muscle deoxyhemoglobin (exercise) [Change from baseline muscle deoxyhemoglobin at the second minute of exercise.]
- Change in muscle deoxyhemoglobin (rest) [Change from baseline muscle deoxyhemoglobin at 7 days.]
- Change in muscle oxyhemoglobin (exercise) [Change from baseline muscle oxyhemoglobin at the second minute of exercise.]
- Change in muscle oxyhemoglobin (rest) [Change from baseline muscle oxyhemoglobin at 7 days.]
Eligibility Criteria
Criteria
Inclusion Criteria:
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subject provides written informed consent.
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normal health profile.
Exclusion Criteria:
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history of musculoskeletal injury in the legs during the previous six months.
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smoker.
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consumption of any medication the last three months.
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consumption of any nutritional supplement the last three months.
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | European University Cyprus | Nicosia | Cyprus | 1516 |
Sponsors and Collaborators
- European University Cyprus
Investigators
- Study Director: Marios Vryonides, Dr., European University Cyprus
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- EUC_cit