Horenso: Can Japanese Traditional Foods Lower Blood Pressure in Healthy Volunteers

• Sponsor: Kyorin University (Other)
• Overall Status: Completed
• CT.gov ID: NCT00928824
• Collaborator: Japanese Society for the Promotion of Science (Other)
• Enrollment: 25
• Location: 1
• Duration (Months): 3
• Patients Per Site Per Month: 8.3

Study Details

Study Description

Brief Summary

The purpose of this study is to determine whether traditional japanese diet blood pressure in healthy volunteers.

Condition or Disease	Intervention/Treatment	Phase
Blood Pressure	Dietary Supplement: traditional Japanese diet	N/A

Detailed Description

Japanese traditional diet contains considerably more nitrate/nitrite than the European foods. 80% of dietary nitrate originates from vegetables. Green leafy vegetables, especially spinach, salad and seaweed are rich in nitrates. Other vegetables contain nitrate at lower concentrations, but because they are consumed in greater quantity, they may contribute more nitrate and thus nitrite from the diet. Nitrate/nitrite is attributed multiple health benefits. Japanese people have an exceptional longevity and the lowest rate of heart diseases. On the other hand, gastric cancer rate is high too. Nitrate/nitrite is strongly correlated with these phenomena. Is this high nitrate consumption protective or damaging? Understanding dietary nitrite and nitrate consumption and its metabolism therefore becomes very important.

Aim: To compare conversion of nitrate to nitrite in Japanese people, measured in blood and in saliva during consumption of traditional Japanese foods vs European diet.

Study Design

• Study Type: Interventional
• Actual Enrollment: 25 participants
• Allocation: Randomized
• Intervention Model: Crossover Assignment
• Masking: None (Open Label)
• Primary Purpose: Basic Science
• Official Title: Dietary Nitrate in Japanese Traditional Foods Lowers Diastolic Blood Pressure in Healthy Volunteers.
• Study Start Date: Jun 1, 2008
• Actual Primary Completion Date: Sep 1, 2008
• Actual Study Completion Date: Sep 1, 2008

Outcome Measures

Primary Outcome Measures

1. Blood pressure []

Eligibility Criteria

Criteria

• Ages Eligible for Study: 20 Years and Older
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Inclusion Criteria:

• healthy volunteers

Exclusion Criteria:

• high/low blood pressure

Contacts and Locations

Locations

	Site	City	State	Country	Postal Code
1	Kyorin Univessity School of Medicine	Tokyo	Mitaka shi	Japan	181-0004

Sponsors and Collaborators

• Kyorin University
• Japanese Society for the Promotion of Science

Investigators

None specified.

Study Documents (Full-Text)

None provided.

More Information

Publications

None provided.

• ClinicalTrials.gov Identifier: NCT00928824
• Other Study ID Numbers: KyorinU
• First Posted: Jun 26, 2009
• Last Update Posted: Jun 26, 2009
• Last Verified: Jun 1, 2009

Study Results

No Results Posted as of Jun 26, 2009