Study of Blood Samples From Patients With Malignant Melanoma, Metastatic Breast Cancer, Advanced Lung Cancer, Pancreatic Cancer, or Colorectal Cancer.

Sponsor

Cancer Trials Ireland (Other)

Overall Status

Completed

CT.gov ID

NCT00974610

Collaborator

(none)

803

Enrollment

Locations

101

Duration (Months)

61.8

Patients Per Site

0.6

Patients Per Site Per Month

Study Details

Study Description

Brief Summary

RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in peptides and proteins and identify biomarkers related to cancer.

PURPOSE: This research study is looking at blood samples from patients with malignant melanoma, metastatic breast cancer, advanced lung cancer, pancreatic cancer, or colorectal cancer.

Condition or Disease	Intervention/Treatment	Phase
Breast Cancer Colorectal Cancer Lung Cancer Melanoma (Skin) Pancreatic Cancer

Detailed Description

OBJECTIVES:

Primary

To assess which potential peptide and protein markers produced by human melanoma, lung, breast, pancreatic, and colorectal cell lines may be detectable in serum of patients from these five disease groups.

Secondary

To conduct further extensive investigation with respect to identification of the protein/peptide involved, determination of specificity for each cancer, and development of more sensitive assays to look for such markers in a wider population of patients, including those undergoing therapy.

OUTLINE: This is a multicenter study.

Blood samples are collected before surgical intervention or treatment to assess peptide and protein markers.

Study Design

Study Type:

Observational

Actual Enrollment :

803 participants

Observational Model:

Other

Time Perspective:

Prospective

Official Title:

Collaborative Project on Potential Serum Markers for Malignant Melanoma, Metastatic Breast, Advanced Lung Pancreatic Carcinoma and Colorectal Cancer

Study Start Date :

Aug 1, 2008

Actual Primary Completion Date :

Dec 1, 2015

Actual Study Completion Date :

Jan 1, 2017

Arms and Interventions

Arm	Intervention/Treatment
Breast
Lung
Melanoma
Pancreatic
Colorectal

Outcome Measures

Primary Outcome Measures

Detection of peptide and protein markers in serum [Ongoing]

Secondary Outcome Measures

Identification of the protein/peptide involved [Ongoing]

Eligibility Criteria

Criteria

Ages Eligible for Study:

N/A and Older

Sexes Eligible for Study:

All

Accepts Healthy Volunteers:

DISEASE CHARACTERISTICS:

Diagnosis of 1 of the following advanced metastatic malignancies:
Malignant melanoma
Lung cancer
Breast cancer
Pancreatic carcinoma
Colorectal cancer
Advanced and/or metastatic disease
Hormone receptor status not specified

PATIENT CHARACTERISTICS:

Menopausal status not specified

PRIOR CONCURRENT THERAPY:

Not specified

Contacts and Locations

Locations

	Site	City	Country	Postal Code
1	Cork University Hospital	Cork	Ireland
2	Mercy University Hospital	Cork	Ireland
3	Adelaide and Meath Hospital, Dublin Incorporating the National Children's Hospital	Dublin	Ireland	24
4	St. Vincent's University Hospital	Dublin	Ireland	4
5	Mater Misericordiae University Hospital	Dublin	Ireland	7
6	St. James's Hospital	Dublin	Ireland	8
7	Beaumont Hospital	Dublin	Ireland	9
8	Mater Private Hospital	Dublin	Ireland
9	St Luke's Hospital	Dublin	Ireland
10	University College Hospital	Galway	Ireland
11	Letterkenny General Hospital	Letterkenny	Ireland
12	Mid-Western Cancer Centre at Mid-Western Regional Hospital	Limerick	Ireland	0009
13	Waterford Regional Hospital	Waterford	Ireland