Blood Transfusions in Preterm Infants
Study Details
Study Description
Brief Summary
A cross sectional study to assess the effect of blood transfusions on the outcome of preterm infants
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Detailed Description
This is a cross sectional study carried on preterm infants who are staying in the hospital as "growers"; to gain weight. We will assess blood transfusion received by these preterm infants in details.
Study Design
Outcome Measures
Primary Outcome Measures
- Change in heart rate [immediately before and immediately after blood transfusion]
Heart rate per minute
- Change in respiratory rate [immediately before and immediately after blood transfusion]
Respiratory rate per minute
- Change in weight gain [within 4 days before and within 4 days after blood transfusion]
Average weight gain in grams/kg/day
- Change in hemoglobin [immediately before and immediately after blood transfusion]
Hemoglobin in grams/dl
- Change in hematocrit value [immediately before and immediately after blood transfusion]
Hematocrit value percentage
Secondary Outcome Measures
- Acute blood loss [in the previous 24 hours before blood transfusion]
Acute blood loss either spontaneous or iatrogenic during invasive procedures
- Mechanical ventilation [in the previous 24 hours before blood transfusion]
Mechanical ventilation (MV) which may be one of two possibilities: Moderate or significant MV; Mean airway pressure (MAP) >8 cm H2O on conventional ventilator or >14 cm H2O on high frequency ventilator and FiO2 >0.4 Minimal MV; MAP ≤8 cmH2O on conventional ventilator or ≤14 cm H2O on high frequency ventilator and FiO2 ≤ 0.4
- Supplemental oxygen [in the previous 24 hours before blood transfusion]
Supplemental oxygen, not mechanically ventilated
- Doubling of oxygen requirements [in the previous 2 days before blood transfusion]
Doubling of oxygen requirements for patients on supplemental oxygen
- Tachycardia [in the previous 24 hours before blood transfusion]
≥24 hours of tachycardia (Heart rate>180/minute)
- Tachypnea [in the previous 24 hours before blood transfusion]
≥24 hours of tachypnea (Respiratory rate>60/minute),
- Poor weight gain [in the previous 4 days before blood transfusion]
≤10 g/kg/day while the infant is receiving ≥120 kcal/kg/day
- Metabolic acidosis [in the previous 24 hours before blood transfusion]
pH <7.2
- Apnea and bradycardia [in the previous 24 hours before blood transfusion]
9 episodes or ≥2 episodes requiring bag and mask ventilation, while infant is receiving caffeine citrate
- Length of stay in the NICU [from date of birth until the date of transfer to the "grower ward" or date of death from any cause, whichever came first, assessed up to 3 months.]
Length of stay in the NICU
- Length of stay in the hospital [from date of birth until the date of discharge home or date of death from any cause, whichever came first, assessed up to 3 months.]
Length of stay in the hospital
- Mortality [from the date of transfer to grower ward, assessed up to 3 months.]
Death
Eligibility Criteria
Criteria
Inclusion Criteria:
- Grower preterm infants
Exclusion Criteria:
- Severe illness, Hypovolemic shock, Hypoxia, Oxygen therapy, Surgical intervention
Contacts and Locations
Locations
No locations specified.Sponsors and Collaborators
- Kasr El Aini Hospital
Investigators
- Study Director: Dahlia El Sebaie, MD, Kasralainy hospital, Faculty of medicine, Cairo University
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- MS-49-2020