Study of Blood and Tumor Samples From Men With an Inherited Risk of Prostate Cancer
Study Details
Study Description
Brief Summary
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify genes related to cancer.
PURPOSE: This clinical trial is studying blood and tumor samples from men with an inherited risk of prostate cancer.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
OBJECTIVES:
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To find genes that predispose to prostate cancer (using genetic linkage and other molecular biology techniques).
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To determine if genes that predispose to prostate cancer are associated with disease and treatment parameters.
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To determine if genes that predispose to prostate cancer are associated with environmental factors.
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To estimate the percentage of prostate cancer patients who have a positive family history of the disease.
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To estimate the relative risk of developing prostate cancer in a currently unaffected member of a prostate cancer family.
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To ascertain whether relatives of prostate cancer patients are at increased risk of developing cancers other than prostate cancer.
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To build up a large blood and tumor (both fresh and preserved) bank from patients with prostate cancer to identify prostate cancer predisposition gene(s), determine the prevalence and penetrance of prostate cancer predisposition genes in prostate cancer patients, correlate changes in prostate cancer predisposition gene(s) with disease and treatment parameters by matching with clinical data from clinical databases already held as part of the medical record on these patients, and correlate changes in prostate cancer predisposition gene(s) with environmental factors collected by questionnaire from these patients.
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To use the blood and tumor bank for marker studies (DNA, RNA, serum, plasma, protein, and other molecules) to define the role of these markers in disease prediction and progression.
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To develop microarrays from prostate cancers to determine their genetic profile and correlate this with prostate cancer genetic predisposition genes.
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To collect tissue from other unaffected and affected members of the family in cases where a genetic alteration is found, in order to ascertain whether this alteration is associated with disease risk.
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To collect tissue samples from unaffected family members who show an interest in taking part in the study.
OUTLINE: Patients are assessed by a family history and epidemiology questionnaire and undergo a medical record review.
Patients and relatives with prostate cancer may undergo blood sample collection for genetic analysis of prostate cancer predisposition genes and measurement of markers of associations with genetic changes associated with prostate cancer. Blood and tumor samples are stored for future studies.
Study Design
Outcome Measures
Primary Outcome Measures
- Prostate cancer (PC) predisposition (PCP) genes []
Secondary Outcome Measures
- Association of PCP genes with disease and treatment parameters []
- Association of PCP with environmental factors []
- Family history of PC []
- Relative risk of developing PC []
- Increased risk relatives of PC patients are to develop cancers other than PC []
- Markers of PC that are associated with PCP genes []
- Specific tumor genetic profile correlated with PCP genes []
Eligibility Criteria
Criteria
DISEASE CHARACTERISTICS:
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Meets 1 of the following criteria:
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Diagnosis of prostate cancer meeting any of the following criteria:
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Attending prostate clinics at The Royal Marsden NHS Foundation Trust
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Any age at diagnosis
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Not attending prostate clinics at The Royal Marsden NHS Foundation Trust, meeting 1 of the following criteria:
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No older than 60 years at diagnosis
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Diagnosis in two relatives where one is ≤ 65 years at diagnosis
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At any age in a cluster with 3 or more cases
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Any unaffected male relatives of men who are already taking part in the study
PATIENT CHARACTERISTICS:
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Able to understand the information sheet and give informed consent
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No man who is too ill to take part
PRIOR CONCURRENT THERAPY:
- Not specified
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | William Harvey Hospital | Ashford-Kent | England | United Kingdom | TN24 0LZ |
| 2 | Tameside General Hospital | Ashton-Under-Lyne | England | United Kingdom | OL6 9RW |
| 3 | Stoke Mandeville Hospital | Aylesbury-Buckinghamshire | England | United Kingdom | HP21 8AL |
| 4 | North Devon District Hospital | Barnstaple | England | United Kingdom | EX31 4JB |
| 5 | Furness General Hospital | Barrow in Furness | England | United Kingdom | LA14 4LF |
| 6 | Basildon University Hospital | Basildon | England | United Kingdom | SS16 5NL |
| 7 | Basingstoke and North Hampshire NHS Foundation Trust | Basingstoke | England | United Kingdom | RG24 9NA |
| 8 | Royal United Hospital | Bath | England | United Kingdom | BA1 3NG |
| 9 | Primrose Centre at Bedford Hospitals NHS Trust | Bedford | England | United Kingdom | MK42 9DJ |
| 10 | Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust | Birmingham | England | United Kingdom | B15 2TH |
| 11 | City Hospital - Birmingham | Birmingham | England | United Kingdom | B18 7QH |
| 12 | Good Hope Hospital | Birmingham | England | United Kingdom | B75 7RR |
| 13 | Birmingham Heartlands Hospital | Birmingham | England | United Kingdom | B9 5SS |
| 14 | Royal Blackburn Hospital | Blackburn | England | United Kingdom | BB2 3 HH |
| 15 | Blackpool Victoria Hospital | Blackpool | England | United Kingdom | FY3 8NR |
| 16 | Pilgrim Hospital | Boston | England | United Kingdom | PE21 9QT |
| 17 | Royal Bournemouth Hospital | Bournemouth | England | United Kingdom | BH7 7DW |
| 18 | Sussex Cancer Centre at Royal Sussex County Hospital | Brighton | England | United Kingdom | BN2 5BE |
| 19 | Southmead Hospital | Bristol | England | United Kingdom | BS10 5NB |
| 20 | Frenchay Hospital | Bristol | England | United Kingdom | BS16 1LE |
| 21 | Bristol Royal Infirmary | Bristol | England | United Kingdom | BS2 8HW |
| 22 | Broomfield Hospital | Broomfield | England | United Kingdom | CM1 7ET |
| 23 | Burnley General Hospital | Burnley | England | United Kingdom | BB10 2PQ |
| 24 | Queen's Hospital | Burton-upon-Trent | England | United Kingdom | DE13 0RB |
| 25 | Addenbrooke's Hospital | Cambridge | England | United Kingdom | CB2 2QQ |
| 26 | Kent and Canterbury Hospital | Canterbury | England | United Kingdom | CT1 3NG |
| 27 | St. Helier Hospital | Carshalton | England | United Kingdom | SM5 1AA |
| 28 | Countess of Chester Hospital | Chester | England | United Kingdom | CH2 1UL |
| 29 | Colchester General Hospital | Colchester | England | United Kingdom | CO4 5JL |
| 30 | Castle Hill Hospital | Cottingham | England | United Kingdom | HU16 5JQ |
| 31 | Walsgrave Hospital | Coventry | England | United Kingdom | CV2 2DX |
| 32 | Mid Cheshire Hospitals Trust- Leighton Hopsital | Crewe | England | United Kingdom | CW1 4QJ |
| 33 | Mayday University Hospital | Croydon | England | United Kingdom | |
| 34 | Darent Valley Hospital | Dartford Kent | England | United Kingdom | DA2 8DA |
| 35 | Derbyshire Royal Infirmary | Derby | England | United Kingdom | DE1 2QY |
| 36 | Royal Derby Hospital | Derby | England | United Kingdom | DE22 3NE |
| 37 | Dorset County Hospital | Dorchester | England | United Kingdom | DT1 2JY |
| 38 | Russells Hall Hospital | Dudley | England | United Kingdom | DY1 2HQ |
| 39 | Eastbourne District General Hospital | Eastbourne | England | United Kingdom | BN21 2UD |
| 40 | Birmingham Women's Hospital | Edgbaston | England | United Kingdom | B15 2TG |
| 41 | Epsom General Hospital | Epsom, Surrey | England | United Kingdom | KT18 7EG |
| 42 | Royal Devon and Exeter Hospital | Exeter | England | United Kingdom | EX2 5DW |
| 43 | Royal Bolton Hospital | Farnworth | England | United Kingdom | BL4 0JR |
| 44 | Frimley Park Hospital | Frimley | England | United Kingdom | GU16 7UJ |
| 45 | Grantham and District Hospital | Grantham, Lincolnshire | England | United Kingdom | NG31 8DG |
| 46 | Diana Princess of Wales Hospital | Grimsby | England | United Kingdom | DN33 2BA |
| 47 | Harrogate District Hospital | Harrogate | England | United Kingdom | HG2 7SX |
| 48 | Wycombe General Hospital | High Wycombe | England | United Kingdom | |
| 49 | Princess Royal Hospital at Hull and East Yorkshire NHS Trust | Hull | England | United Kingdom | HU8 9HE |
| 50 | Ipswich Hospital | Ipswich | England | United Kingdom | IP4 5PD |
| 51 | Kidderminster Hospital | Kidderminster Worcestershire | England | United Kingdom | DY11 6RJ |
| 52 | Royal Albert Edward Infirmary | Lancanshire | England | United Kingdom | WN1 2NN |
| 53 | Royal Lancaster Infirmary | Lancaster | England | United Kingdom | LA1 4RP |
| 54 | Leeds General Infirmary | Leeds | England | United Kingdom | LS1 3EX |
| 55 | Cookridge Hospital | Leeds | England | United Kingdom | LS16 6QB |
| 56 | Leeds Cancer Centre at St. James's University Hospital | Leeds | England | United Kingdom | LS9 7TF |
| 57 | Leicester Royal Infirmary | Leicester | England | United Kingdom | LE1 5WW |
| 58 | Leicester General Hospital | Leicester | England | United Kingdom | LE5 4PW |
| 59 | Lincoln County Hospital | Lincoln | England | United Kingdom | LN2 5QY |
| 60 | Royal Liverpool University Hospital | Liverpool | England | United Kingdom | L7 8XP |
| 61 | Royal London Hospital | London | England | United Kingdom | E1 1BB |
| 62 | Whipps Cross Hospital | London | England | United Kingdom | E11 1NR |
| 63 | Saint Bartholomew's Hospital | London | England | United Kingdom | EC1A 7BE |
| 64 | Guy's Hospital | London | England | United Kingdom | SE1 9RT |
| 65 | Hammersmith Hospital | London | England | United Kingdom | W12 OHS |
| 66 | Middlesex Hospital | London | England | United Kingdom | W1T 3AA |
| 67 | St. Mary's Hospital | London | England | United Kingdom | W2 1NY |
| 68 | Charing Cross Hospital | London | England | United Kingdom | W6 8RF |
| 69 | Macclesfield District General Hospital | Macclesfield | England | United Kingdom | SK10 3BL |
| 70 | Maidstone Hospital | Maidstone | England | United Kingdom | ME16 9QQ |
| 71 | Christie Hospital | Manchester | England | United Kingdom | M20 4BX |
| 72 | Clatterbridge Centre for Oncology | Merseyside | England | United Kingdom | CH63 4JY |
| 73 | James Cook University Hospital | Middlesbrough | England | United Kingdom | TS4 3BW |
| 74 | Milton Keynes General Hospital | Milton Keynes | England | United Kingdom | MK6 5LD |
| 75 | Newcastle Upon Tyne Hospitals NHS Trust | Newcastle-Upon-Tyne | England | United Kingdom | NE7 7DN |
| 76 | Mount Vernon Cancer Centre at Mount Vernon Hospital | Northwood | England | United Kingdom | HA6 2RN |
| 77 | Norfolk and Norwich University Hospital | Norwich | England | United Kingdom | NR4 7UY |
| 78 | Kings Mill Hospital | Nottinghamshire | England | United Kingdom | NG17 4JL |
| 79 | Nottingham City Hospital | Nottingham | England | United Kingdom | NG5 1PB |
| 80 | George Eliot Hospital | Nuneaton | England | United Kingdom | CV10 7DJ |
| 81 | Churchill Hospital | Oxford | England | United Kingdom | OX3 7LJ |
| 82 | Peterborough Hospitals Trust | Peterborough | England | United Kingdom | PE3 6DA |
| 83 | Derriford Hospital | Plymouth | England | United Kingdom | PL6 8DH |
| 84 | Dorset Cancer Centre | Poole Dorset | England | United Kingdom | BH15 2JB |
| 85 | Rosemere Cancer Centre at Royal Preston Hospital | Preston | England | United Kingdom | PR2 9HT |
| 86 | Berkshire Cancer Centre at Royal Berkshire Hospital | Reading | England | United Kingdom | RG1 5AN |
| 87 | Alexandra Healthcare NHS | Redditch, Worcestershire | England | United Kingdom | B98 7UB |
| 88 | Queens Hospital | Romford | England | United Kingdom | RM3 0BE |
| 89 | Conquest Hospital | Saint Leonards-on-Sea | England | United Kingdom | TN37 7RD |
| 90 | Hope Hospital | Salford | England | United Kingdom | M6 8HD |
| 91 | Salisbury District Hospital | Salisbury | England | United Kingdom | SP2 8BJ |
| 92 | Scarborough General Hospital | Scarborough | England | United Kingdom | YO12 6QL |
| 93 | Scunthorpe General Hospital | Scunthorpe | England | United Kingdom | DN15 7BH |
| 94 | Royal Shrewsbury Hospital | Shrewsbury | England | United Kingdom | SY3 8XQ |
| 95 | Wexham Park Hospital | Slough, Berkshire | England | United Kingdom | SL2 4HL |
| 96 | Solihull Hospital | Solihull | England | United Kingdom | B91 2JL |
| 97 | Southampton General Hospital | Southampton | England | United Kingdom | SO16 6YD |
| 98 | Southport and Formby District General Hospital | Southport | England | United Kingdom | PR8 6PN |
| 99 | Staffordshire General Hospital | Stafford | England | United Kingdom | ST16 3SA |
| 100 | Lister Hospital | Stevenage | England | United Kingdom | SG1 4AB |
| 101 | Stirling Royal Infirmary | Stirling | England | United Kingdom | FK8 2AU |
| 102 | Stepping Hill Hospital | Stockport | England | United Kingdom | SK2 7JE |
| 103 | Kingston Hospital | Surrey | England | United Kingdom | KT2 7QB |
| 104 | East Surrey Hospital | Surrey | England | United Kingdom | RH1 5RH |
| 105 | Royal Marsden - Surrey | Sutton | England | United Kingdom | SM2 5PT |
| 106 | Great Western Hospital | Swindon | England | United Kingdom | SN3 6BB |
| 107 | Taunton and Somerset Hospital | Taunton | England | United Kingdom | TA1 5DA |
| 108 | Torbay Hospital | Torquay | England | United Kingdom | TQ2 7AA |
| 109 | Hillingdon Hospital | Uxbridge | England | United Kingdom | UB8 3NN |
| 110 | Warwick Hospital | Warwick | England | United Kingdom | CV34 5BW |
| 111 | Sandwell General Hospital | West Bromwich | England | United Kingdom | B71 4HJ |
| 112 | Southend University Hospital NHS Foundation Trust | Westcliff-On-Sea | England | United Kingdom | SS0 0RY |
| 113 | New Cross Hospital | Wolverhampton | England | United Kingdom | WV10 0QP |
| 114 | Worthing Hospital | Worthing | England | United Kingdom | BN11 2DH |
| 115 | Yeovil District Hospital | Yeovil | England | United Kingdom | BA21 4AT |
| 116 | Cancer Care Centre at York Hospital | York | England | United Kingdom | Y031 8HE |
| 117 | Belfast City Hospital Trust Incorporating Belvoir Park Hospital | Belfast | Northern Ireland | United Kingdom | BT8 8JR |
| 118 | Downe Hospital | Downpatrick | Northern Ireland | United Kingdom | BT30 6JA |
| 119 | Altnagelvin Area Hospital | Londonderry | Northern Ireland | United Kingdom | BT47 1SB |
| 120 | Craigavon Area Hospital | Portadown, Craigavon | Northern Ireland | United Kingdom | BT63 5QQ |
| 121 | Aberdeen Royal Infirmary | Aberdeen | Scotland | United Kingdom | AB25 2ZN |
| 122 | Ayr Hospital | Ayr | Scotland | United Kingdom | KA6 6DX |
| 123 | Falkirk and District Royal Infirmary | Falkirk | Scotland | United Kingdom | FK1 5QE |
| 124 | Western Infirmary | Glasgow | Scotland | United Kingdom | G11 6NT |
| 125 | Pinderfields General Hospital | Wakefield | Scotland | United Kingdom | WF1 4DG |
| 126 | Princess of Wales Hospital | Bridgend | Wales | United Kingdom | CF31 1JP |
| 127 | Velindre Cancer Center at Velindre Hospital | Cardiff | Wales | United Kingdom | CF14 2TL |
| 128 | University Hospital of Wales | Cardiff | Wales | United Kingdom | CF14 4XW |
| 129 | Royal Gwent Hospital | Newport Gwent | Wales | United Kingdom | NP9 2UB |
| 130 | Glan Clwyd Hospital | Rhyl, Denbighshire | Wales | United Kingdom | LL 18 5UJ |
| 131 | Singleton Hospital | Swansea | Wales | United Kingdom | SA2 8QA |
| 132 | Queen Victoria Hospital | Morecambe | United Kingdom | LA4 5NN | |
| 133 | Edith Cavell Hospital | Peterborough | United Kingdom | PE3 9GZ | |
| 134 | Southlands Hospital | Shoreham-by-Sea | United Kingdom | BN43 6TQ | |
| 135 | Princess Anne Hospital | Southampton | United Kingdom | SO16 5YA |
Sponsors and Collaborators
- Institute of Cancer Research, United Kingdom
Investigators
- Principal Investigator: Rosalind Eeles, PhD, FRCR, FRCP, FMed Sci, Royal Marsden NHS Foundation Trust
Study Documents (Full-Text)
None provided.More Information
Publications
None provided.- CDR0000636371
- ICR-UKGPCS
- EU-20909