COVID-MUSCLE: Body Composition Study in Critically Ill Patients-Extended to COVID-19
Study Details
Study Description
Brief Summary
Muscle loss (ultrasound quadricep muscle) and muscle strength (handgrip and knee extension strength) will be compared between COVID-19 and non COVID-19 critically ill patients.
| Condition or Disease | Intervention/Treatment | Phase |
|---|---|---|
|
Detailed Description
Given the heightened inflammatory status among COVID-19 critically ill patients, we hypothesized that the rate of skeletal muscle loss is accelerated in this population, and this loss is even more pronounce than the general critically ill patients. We further hypothesized that the increased muscle loss will lead to worse functional outcome (lower muscle strength) in COVID-19 critically ill patients compared with age- and sex-matched non-COVID-19 critically ill patients, as it has been shown that quadriceps thickness is strongly correlated with functional status at ICU discharge. Furthermore, a recent systematic review and meta-analysis in survivors of coronavirus (severe acute respiratory syndrome, SARS or Middle-east respiratory syndrome, MERS, or COVID-19) also demonstrated reduced exercise capacity and quality of life at 6 months after hospitalization or ICU admission
Study Design
Arms and Interventions
| Arm | Intervention/Treatment |
|---|---|
| ICU COVID-19 patients COVID-19 patients that are admitted into the ICU and fulfilled the eligibility criteria |
Other: No Intervention
This is an observational study and involved no intervention
|
| ICU non-COVID-19 patients Non-COVID-19 patients that are admitted into the ICU matched with ICU COVID-19 patients that are recruited and fulfilled the eligibility criteria |
Other: No Intervention
This is an observational study and involved no intervention
|
Outcome Measures
Primary Outcome Measures
- Rectus Femoris Thickness [Change in Rectus Femoris Thickness at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission)]
Change in Rectus Femoris Thickness
- Rectus Femoris Cross-sectional Area [Change in Rectus Femoris Cross-sectional Area at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission)]
Change in Rectus Femoris Cross-sectional Area
Secondary Outcome Measures
- Forearm Muscle Thickness [Change in Forearm Muscle Thickness at day 7 or ICU discharge or hospital discharge compared with baseline (Day 1 of ICU admission)]
Change in Forearm Muscle Thickness
- Handgrip Strength [Before Hospital Discharge]
BIlateral Handgrip Strength
- Knee Extension Strength [Before Hospital Discharge]
BIlateral Knee Extension Strength
Other Outcome Measures
- Mortality [Mortality at day 28 (calculated from the first day of ICU admission)]
28-day Mortality
- ICU length of stay [From date of enrolment until the date of discharged from the ICU, assessed up to 60 days]
Length of stay in the ICU
- Hospital length of stay [From date of enrolment until the date of discharged from the hospital, assessed up to 60 days]
Length of stay in the Hospital
- Length of Mechanical Ventilation [From date of commencement of mechanical ventilation until the date of liberation from mechanical ventilation, assessed up to 60 days]
Duration of Mechanical Ventilation
Eligibility Criteria
Criteria
Inclusion Criteria:
-
≥ 18 years old
-
Admitted into the ICU due to COVID-19
Exclusion Criteria:
-
Likely to transfer out from the ICU in 24 hours from screening
-
Likely to die in the next 7 days
-
Bedbound prior to hospital admission or bedbound in the hospital for >10 days
Contacts and Locations
Locations
| Site | City | State | Country | Postal Code | |
|---|---|---|---|---|---|
| 1 | Faculty of Medicine, University of Malaya | Kuala Lumpur | Malaysia | 50603 |
Sponsors and Collaborators
- University of Malaya
Investigators
None specified.Study Documents (Full-Text)
None provided.More Information
Publications
- 2019615-7520-3